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1981 30
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90 results

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Page 1
Synthesis of 6-chloro-2-Aryl-1H-imidazo[4,5-b]pyridine derivatives: Antidiabetic, antioxidant, beta-glucuronidase inhibiton and their molecular docking studies.
Taha M, Ismail NH, Imran S, Rashwan H, Jamil W, Ali S, Kashif SM, Rahim F, Salar U, Khan KM. Taha M, et al. Bioorg Chem. 2016 Apr;65:48-56. doi: 10.1016/j.bioorg.2016.01.007. Epub 2016 Feb 1. Bioorg Chem. 2016. PMID: 26855413
6-Chloro-2-Aryl-1H-imidazo[4,5-b]pyridine derivatives 1-26 were synthesized and characterized by various spectroscopic techniques. ...
6-Chloro-2-Aryl-1H-imidazo[4,5-b]pyridine derivatives 1-26 were synthesized and characterized by v …
Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase.
Newhouse BJ, Wenglowsky S, Grina J, Laird ER, Voegtli WC, Ren L, Ahrendt K, Buckmelter A, Gloor SL, Klopfenstein N, Rudolph J, Wen Z, Li X, Feng B. Newhouse BJ, et al. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5896-9. doi: 10.1016/j.bmcl.2013.08.086. Epub 2013 Aug 29. Bioorg Med Chem Lett. 2013. PMID: 24042006
Protective activity of probiotic bacteria against 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (PhIP) - an in vitro study.
Nowak A, Czyżowska A, Stańczyk M. Nowak A, et al. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(11):1927-38. doi: 10.1080/19440049.2015.1084651. Epub 2015 Sep 18. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015. PMID: 26295367
The aim of the study was in vitro assessment of the protective activity of the probiotic strains Lb. rhamnosus 0900, Lb. rhamnosus 0908, Lb. casei 0919 and Lb. casei DN 114001 against IQ (2-amino-3-methyl-3H-imidazo[4,5-f]quinoline) and PhIP (2-amino-1-methyl-6-phenyl-1H- …
The aim of the study was in vitro assessment of the protective activity of the probiotic strains Lb. rhamnosus 0900, Lb. rhamnosus 0908, Lb. …
Synthesis and decomposition of an ester derivative of the procarcinogen and promutagen, PhIP, 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine: unusual nitrenium ion chemistry.
Nguyen TM, Novak M. Nguyen TM, et al. J Org Chem. 2007 Jun 22;72(13):4698-706. doi: 10.1021/jo070306p. Epub 2007 Jun 2. J Org Chem. 2007. PMID: 17542636
The food-derived heterocyclic amine (HCA) carcinogen 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine, PhIP, is often generated in the highest concentration of the HCAs formed during broiling and frying of meat and fish. ...We have syn …
The food-derived heterocyclic amine (HCA) carcinogen 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridi …
Synthesis, biological evaluation and molecular docking studies of 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives as novel antitubercular agents: future DprE1 inhibitors.
Gawad J, Bonde C. Gawad J, et al. Chem Cent J. 2018 Dec 19;12(1):138. doi: 10.1186/s13065-018-0515-1. Chem Cent J. 2018. PMID: 30569203 Free PMC article.
Here, Ligand-based drug design approach yielded a series of 23 novel 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives. The required building block of imidazopyridine was synthesized from commercially available 5,5-diaminopyridine- …
Here, Ligand-based drug design approach yielded a series of 23 novel 6-(4-nitrophenoxy)-1H-imidazo[4,5-b] …
Further studies on imidazo[4,5-b]pyridine AT1 angiotensin II receptor antagonists. Effects of the transformation of the 4-phenylquinoline backbone into 4-phenylisoquinolinone or 1-phenylindene scaffolds.
Cappelli A, Pericot Mohr Gl, Giuliani G, Galeazzi S, Anzini M, Mennuni L, Ferrari F, Makovec F, Kleinrath EM, Langer T, Valoti M, Giorgi G, Vomero S. Cappelli A, et al. J Med Chem. 2006 Nov 2;49(22):6451-64. doi: 10.1021/jm0603163. J Med Chem. 2006. PMID: 17064065
The discovery and the structural basis of an imidazo[4,5-b]pyridine-based p21-activated kinase 4 inhibitor.
Park JK, Kim S, Han YJ, Kim SH, Kang NS, Lee H, Park S. Park JK, et al. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2580-3. doi: 10.1016/j.bmcl.2016.04.037. Epub 2016 Apr 16. Bioorg Med Chem Lett. 2016. PMID: 27117431
In this study, an imidazo[4,5-b]pyridine-based PAK4 inhibitor, KY-04045 (6-Bromo-2-(3-isopropyl-1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyridine), was discovered using a virtual site-directed fragment-based drug design and was validate …
In this study, an imidazo[4,5-b]pyridine-based PAK4 inhibitor, KY-04045 (6-Bromo-2-(3-isopropyl-1-methyl-1H-pyrazol-4-yl)-1H-imida …
90 results