Abstract
Investigation of the leaf extract of Picrolemma pseudocoffea afforded a new antineoplastic quassinoid, 15-deacetylsergeolide (3), and two known quassinoids, isobruceine B (1) and sergeolide (2). The structure of 3, which displayed strong antileukemic activity in the P-388 test system, was established through the interpretation of spectral data and chemical correlation to 2.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Chemical Phenomena
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Chemistry
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Crystallization
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Leukemia P388 / drug therapy*
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Leukemia, Experimental / drug therapy*
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Mice
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Phenanthrenes / isolation & purification*
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Phenanthrenes / pharmacology
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Plants, Medicinal / analysis
Substances
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Antineoplastic Agents, Phytogenic
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Phenanthrenes
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15-deacetylsergeolide