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The oxidation of azaheterocycles with mammalian liver aldehyde oxidase.
Stubley C, Stell JG, Mathieson DW. Stubley C, et al. Xenobiotica. 1979 Aug;9(8):475-84. doi: 10.3109/00498257909087261. Xenobiotica. 1979. PMID: 516790
The oxidation products, 1-hydroxyisoquinoline, 4-hydroxycinnoline, 2-hydroxy- and 2,3-dihydroxy-quinoxaline, 4-hydroxy- and 2,4-dihydroxy-quinazoline, and 1-hydroxyphthalazine were identified by comparison of their spectral and chromatographic characteristics with t …
The oxidation products, 1-hydroxyisoquinoline, 4-hydroxycinnoline, 2-hydroxy- and 2,3-dihydroxy-quinoxaline, 4-hydroxy- and 2,4-dihydroxy-qu …
Elevation of molybdenum hydroxylase levels in rabbit liver after ingestion of phthalazine or its hydroxylated metabolite.
Johnson C, Stubley-Beedham C, Stell JG. Johnson C, et al. Biochem Pharmacol. 1984 Nov 15;33(22):3699-705. doi: 10.1016/0006-2952(84)90159-x. Biochem Pharmacol. 1984. PMID: 6548914
Oral administration of phthalazine (50 mg/kg/day) or 1-hydroxyphthalazine (10 mg/kg/day) to female rabbits caused an increase in the specific activity of the hepatic molybdenum hydroxylases aldehyde oxidase and xanthine oxidase, whereas no effect on microsomal cytoc …
Oral administration of phthalazine (50 mg/kg/day) or 1-hydroxyphthalazine (10 mg/kg/day) to female rabbits caused an increase …