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Page 1
Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits.
Collett MG, Matthews ZM, Parton KH. Collett MG, et al. Toxins (Basel). 2020 Nov 2;12(11):695. doi: 10.3390/toxins12110695. Toxins (Basel). 2020. PMID: 33147822 Free PMC article.
Apart from goitrin, progoitrin hydrolysis yields the nitrile, 1-cyano-2-hydroxy-3-butene (CHB), and the epithionitrile, 1-cyano-2-hydroxy-3,4-epithiobutane (CHEB). ...
Apart from goitrin, progoitrin hydrolysis yields the nitrile, 1-cyano-2-hydroxy-3-butene (CHB), an …
Metabolomic analysis of serum from pure coronary artery ectasia patients based on UPLC-QE/MS technique.
Cao Z, Wang J, Weng Z, Tao X, Xu Y, Li X, Tan X, Liu Z, Qu C. Cao Z, et al. Clin Chim Acta. 2022 Sep 1;534:93-105. doi: 10.1016/j.cca.2022.06.026. Epub 2022 Jul 16. Clin Chim Acta. 2022. PMID: 35853548 Free article.
RESULTS: Ten metabolites distinguished pure CAE patients from controls and mixed CAE, including 1-cyano-2-hydroxy-3-butene, 2,3-dihydro-6-methyl-5-(5-methyl-2-furanyl)-1H-pyrrolizine, 2-propionylpyrrole, 2-pyrrolidinone, 3-(2-furanylmethy …
RESULTS: Ten metabolites distinguished pure CAE patients from controls and mixed CAE, including 1-cyano-2-hydroxy …
Studies on the toxic effects of crambe meal and two of its constituents, 1-cyano-2-hydroxy-3-butene (CHB) and epi-progoitrin, in broiler chick diets.
Kloss P, Jeffery E, Tumbleson M, Zhang Y, Parsons C, Wallig M. Kloss P, et al. Br Poult Sci. 1996 Dec;37(5):971-86. doi: 10.1080/00071669608417928. Br Poult Sci. 1996. PMID: 9034587
Studies were undertaken to determine a safe inclusion rate for crambe (Crambe abyssinica) meal in broiler chick diets, and to determine the mechanism for adverse effects by investigating its constituents; 1-cyano-2-hydroxy-3-butene (CHB) …
Studies were undertaken to determine a safe inclusion rate for crambe (Crambe abyssinica) meal in broiler chick diets, and to determine the …
The in vitro toxicity of nitrile and epithionitrile derivatives of glucosinolates from swedes (Brassica napus) in human and bovine liver cells.
Latimer I, Chand R, Cridge B. Latimer I, et al. N Z Vet J. 2021 May;69(3):165-173. doi: 10.1080/00480169.2021.1875933. Epub 2021 Feb 11. N Z Vet J. 2021. PMID: 33570481
AIM: To investigate the direct in vitro toxicity in human and bovine liver cells, and inhibition of activity of ATP-binding cassette transporter G2 (ABCG2) and cytochrome P450 3A4 (CYP3A4) by five nitrile and epithionitrile derivatives from swede (Brassica napus). METHODS: The fo …
AIM: To investigate the direct in vitro toxicity in human and bovine liver cells, and inhibition of activity of ATP-binding cassette transpo …
Synergy among phytochemicals within crucifers: does it translate into chemoprotection?
Wallig MA, Heinz-Taheny KM, Epps DL, Gossman T. Wallig MA, et al. J Nutr. 2005 Dec;135(12 Suppl):2972S-2977S. doi: 10.1093/jn/135.12.2972S. J Nutr. 2005. PMID: 16317157 Free article.
These phytochemicals enhance endogenous detoxification, leading to inactivation of potential carcinogens before initiation occurs. Two derivatives, indole-3-carbinol (I3C) and 1-cyano-2-hydroxy-3-butene (crambene) were shown in rats to in …
These phytochemicals enhance endogenous detoxification, leading to inactivation of potential carcinogens before initiation occurs. Two deriv …
Metabonomic investigations into the global biochemical sequelae of exposure to the pancreatic toxin 1-cyano-2-hydroxy-3-butene in the rat.
Bohus E, Rácz A, Noszál B, Coen M, Beckonert O, Keun HC, Ebbels TM, Cantor GH, Wijsman JA, Holmes E, Lindon JC, Nicholson JK. Bohus E, et al. Magn Reson Chem. 2009 Dec;47 Suppl 1:S26-35. doi: 10.1002/mrc.2485. Magn Reson Chem. 2009. PMID: 19639609
The time-related metabolic effects of 1-cyano-2-hydroxy-3-butene (CHB, crambene), a naturally occurring nitrile and experimental model toxin causing exocrine pancreatitis, have been investigated in rats using high-resolution NMR spectrosc …
The time-related metabolic effects of 1-cyano-2-hydroxy-3-butene (CHB, crambene), a naturally occu …
Investigating the cause of Brassica-associated liver disease (BALD) in cattle: Progoitrin-derived nitrile toxicosis in rats.
Matthews ZM, Parton KH, Collett MG. Matthews ZM, et al. Toxicon X. 2019 Dec 30;5:100021. doi: 10.1016/j.toxcx.2019.100021. eCollection 2020 Mar. Toxicon X. 2019. PMID: 32550577 Free PMC article.
Analysis of swede plant material showed that the ultra-dominant glucosinolate was progoitrin. The two nitrile derivatives of progoitrin, 1-cyano-2-hydroxy-3-butene (CHB, also known as crambene) and 1-cyano-2-hydroxy-3,4-epithiobutane (CHE …
Analysis of swede plant material showed that the ultra-dominant glucosinolate was progoitrin. The two nitrile derivatives of progoitrin, …
Selective pancreato-toxicity in the rat induced by the naturally occurring plant nitrile 1-cyano-2-hydroxy-3-butene.
Wallig MA, Gould DH, Fettman MJ. Wallig MA, et al. Food Chem Toxicol. 1988 Feb;26(2):137-47. doi: 10.1016/0278-6915(88)90110-x. Food Chem Toxicol. 1988. PMID: 2452775
The acute toxicity of 1-cyano-2-hydroxy-3-butene (CHB), a nitrile derived from many cruciferous plants, was investigated. ...
The acute toxicity of 1-cyano-2-hydroxy-3-butene (CHB), a nitrile derived from many cruciferous pl …
The relationship of vehicle to target organ toxicology induced by the naturally occurring nitrile 1-cyano-2-hydroxy-3-butene.
Wallig MA, Gould DH, van Steenhouse J, Fettman MJ, Willhite CC. Wallig MA, et al. Fundam Appl Toxicol. 1989 Apr;12(3):377-85. doi: 10.1016/0272-0590(89)90013-4. Fundam Appl Toxicol. 1989. PMID: 2731654
The effects of gavage vehicle on the acute toxicity of the naturally occurring nitrile 1-cyano-2-hydroxy-3-butene (CHB) were investigated by oral administration of 200 mg/kg body wt/day CHB to male CDF (F-344/Crl BR) rats for 2 days. ...
The effects of gavage vehicle on the acute toxicity of the naturally occurring nitrile 1-cyano-2-hydroxy-3 …
32 results