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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1992 1
1994 1
2000 1
2001 1
2005 1
2006 2
2008 2
2010 1
2011 3
2012 2
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2014 1
2015 1
2023 1
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19 results

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Page 1
Synthesis of 1-(4-Bromobenzoyl)-1,3-dicyclohexylurea and Its Arylation via Readily Available Palladium Catalyst-Their Electronic, Spectroscopic, and Nonlinear Optical Studies via a Computational Approach.
Maqbool T, Younas H, Bilal M, Rasool N, Bajaber MA, Mubarik A, Parveen B, Ahmad G, Ali Shah SA. Maqbool T, et al. ACS Omega. 2023 Aug 11;8(33):30306-30314. doi: 10.1021/acsomega.3c03183. eCollection 2023 Aug 22. ACS Omega. 2023. PMID: 37636953 Free PMC article.
In this study, we reported the synthesis of 1-(4-bromobenzoyl)-1,3-dicyclohexylurea by the reaction of DCC (N,N'-dicyclohexylcarbodiimide) with 4-bromobenzoic acid. Subsequently, we further synthesized a new series of 1-(4-arylbenzoyl)-1,3-di …
In this study, we reported the synthesis of 1-(4-bromobenzoyl)-1,3-dicyclohexylurea by the reaction of DCC (N,N'-dicycl …
Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats.
Ghosh S, Chiang PC, Wahlstrom JL, Fujiwara H, Selbo JG, Roberds SL. Ghosh S, et al. Basic Clin Pharmacol Toxicol. 2008 May;102(5):453-8. doi: 10.1111/j.1742-7843.2008.00213.x. Epub 2008 Feb 29. Basic Clin Pharmacol Toxicol. 2008. PMID: 18312493 Free article.
EETs are hydrolyzed to their less active diols, dihydroxyeicosatrienoic acids (DHET), by the enzyme soluble epoxide hydrolase (sEH). 1,3-dicyclohexylurea (DCU), a potent sEH inhibitor, lowers systemic blood pressure in spontaneously hypertensive rats when dos …
EETs are hydrolyzed to their less active diols, dihydroxyeicosatrienoic acids (DHET), by the enzyme soluble epoxide hydrolase (sEH). 1 …
Development of Ecom50 and retention index models for nontargeted metabolomics: identification of 1,3-dicyclohexylurea in human serum by HPLC/mass spectrometry.
Hall LM, Hall LH, Kertesz TM, Hill DW, Sharp TR, Oblak EZ, Dong YW, Wishart DS, Chen MH, Grant DF. Hall LM, et al. J Chem Inf Model. 2012 May 25;52(5):1222-37. doi: 10.1021/ci300092s. Epub 2012 Apr 27. J Chem Inf Model. 2012. PMID: 22489687 Free PMC article.
As a test of the validity of the filtering approach, the Ecom50 and retention index models, along with exact mass and collision induced dissociation spectra matching, were used to identify 1,3-dicyclohexylurea in human plasma. This compound was not previously …
As a test of the validity of the filtering approach, the Ecom50 and retention index models, along with exact mass and collision induced diss …
Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3-dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery.
Chiang PC, Ran Y, Chou KJ, Cui Y, Wong H. Chiang PC, et al. Nanoscale Res Lett. 2011 Jun 7;6(1):413. doi: 10.1186/1556-276X-6-413. Nanoscale Res Lett. 2011. PMID: 21711942 Free PMC article.
1,3-Dicyclohexylurea (DCU), a potent soluble epoxide hydrolase (sEH) inhibitor has been reported to lower systemic blood pressure in spontaneously hypertensive rats. ...
1,3-Dicyclohexylurea (DCU), a potent soluble epoxide hydrolase (sEH) inhibitor has been reported to lower systemic bloo …
A facile, one-pot synthesis, characterization and antimicrobial activity of o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids.
Farshori NN, Ahmad A, Khan AU, Rauf A. Farshori NN, et al. Eur J Med Chem. 2011 Apr;46(4):1433-8. doi: 10.1016/j.ejmech.2011.01.070. Epub 2011 Feb 22. Eur J Med Chem. 2011. PMID: 21345547
A series of novel o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids have been synthesized. ...
A series of novel o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic …
2-chloroethanol formation as evidence for a 2-chloroethyl alkylating intermediate during chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.
Reed DJ, May HE, Boose RB, Gregory KM, Beilstein MA. Reed DJ, et al. Cancer Res. 1975 Mar;35(3):568-76. Cancer Res. 1975. PMID: 1116123
Other degradation products observed included acetaldehyde (5 to 10%), vinyl chloride (1 to 2%), ethylene (1 to 2%), and cyclohexylamine (32%), but not 1,3-dicyclohexylurea. The 2-chlorethyl moiety of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea was trapped wi …
Other degradation products observed included acetaldehyde (5 to 10%), vinyl chloride (1 to 2%), ethylene (1 to 2%), and cyclohexylamine (32% …
Thermal degradation of amorphous glibenclamide.
Rehder S, Sakmann A, Rades T, Leopold CS. Rehder S, et al. Eur J Pharm Biopharm. 2012 Jan;80(1):203-8. doi: 10.1016/j.ejpb.2011.07.009. Epub 2011 Sep 2. Eur J Pharm Biopharm. 2012. PMID: 21907802
The crystals formed during sublimation of amorphous glibenclamide do not represent a glibenclamide polymorph, but a thermal degradation product, namely 1,3-dicyclohexylurea. The reaction mechanism is suggested to be an elimination of cyclohexylisocyanate from …
The crystals formed during sublimation of amorphous glibenclamide do not represent a glibenclamide polymorph, but a thermal degradation prod …
17 beta-acylurea derivatives of 4-azasteroids as inhibitors of testosterone 5 alpha-reductase.
Di Salle E, Briatico G, Giudici D, Ornati G, Nesi M, Panzeri A. Di Salle E, et al. J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):765-8. doi: 10.1016/0960-0760(92)90420-n. J Steroid Biochem Mol Biol. 1992. PMID: 1373305
The most active derivatives were 1-[4-methyl-3-oxo-4-aza-5 alpha-androstane-17 beta-carbonyl]- 1,3-dicyclohexylurea (compound 1) and 1-[4-methyl-3-oxo-4-aza-5 alpha-androstane-17 beta-carbonyl]- 1,3-diisopropylurea (compound 3) which demonstrated IC50 values …
The most active derivatives were 1-[4-methyl-3-oxo-4-aza-5 alpha-androstane-17 beta-carbonyl]- 1,3-dicyclohexylurea (co …
19 results