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Page 1
Repair replication characteristics of human cells exposed to 1'-acetoxysafrole or 1'-acetoxyestragole.
Phillips DH, Hanawalt PC. Phillips DH, et al. Carcinogenesis. 1982;3(8):929-34. doi: 10.1093/carcin/3.8.929. Carcinogenesis. 1982. PMID: 7127673
The response of cultured human cells to treatment with 1'-acetoxysafrole (1'-AcO-S) and 1'-acetoxyestragole (1'-AcO-E), which are electrophilic and mutagenic, has been examined. ...
The response of cultured human cells to treatment with 1'-acetoxysafrole (1'-AcO-S) and 1'-acetoxyestragole (1'-AcO-E), which …
Alkali-sensitive sites in DNA from human cells treated with ultraviolet light, 1'-acetoxysafrole or 1'-acetoxyestragole.
Phillips DH, Hanawalt PC. Phillips DH, et al. Carcinogenesis. 1982;3(8):935-40. doi: 10.1093/carcin/3.8.935. Carcinogenesis. 1982. PMID: 7127674
The formation and repair of alkali-labile sites in the DNA of human cells treated with 254 nm u.v. light, 1'-acetoxyestragole (1'-AcO-E) or 1'-acetoxysafrole (1'-AcO-S) have been studied. DNA was analysed by sedimentation in alkaline sucrose gradients after the cell …
The formation and repair of alkali-labile sites in the DNA of human cells treated with 254 nm u.v. light, 1'-acetoxyestragole (1'-AcO-E) or …
Hepatocarcinogenicity of estragole (1-allyl-4-methoxybenzene) and 1'-hydroxyestragole in the mouse and mutagenicity of 1'-acetoxyestragole in bacteria.
Drinkwater NR, Miller EC, Miller JA, Pitot HC. Drinkwater NR, et al. J Natl Cancer Inst. 1976 Dec;57(6):1323-31. doi: 10.1093/jnci/57.6.1323. J Natl Cancer Inst. 1976. PMID: 187802
Of the mice given a total dose of 4.4 mumoles of 1'-hydroxysafrole, 59developed hepatocellular carcinomas; 39% of the mice bore multiple liver tumors. As previsously demonstrated for 1'-acetoxysafrole, 1'-acetoxyestragole and 1'-acetoxy-1-allyl-4-methoxynaphthalene …
Of the mice given a total dose of 4.4 mumoles of 1'-hydroxysafrole, 59developed hepatocellular carcinomas; 39% of the mice bore multiple liv …
The in vivo formation and repair of DNA adducts from 1'-hydroxysafrole.
Phillips DH, Hanawalt PC, Miller JA, Miller EC. Phillips DH, et al. J Supramol Struct Cell Biochem. 1981;16(1):83-90. doi: 10.1002/jsscb.1981.380160108. J Supramol Struct Cell Biochem. 1981. PMID: 7299840
Repair replication was measured in cultured human T98G cells exposed to 1'-acetoxysafrole using the combined 5-bromodeoxyuridine density label and radioisotopic label method. At a concentration of 1 mM 1'-acetoxysafrole, the amount of repair synthesis …
Repair replication was measured in cultured human T98G cells exposed to 1'-acetoxysafrole using the combined 5-bromodeoxyuridi …
The metabolic activation of the carcinogen 1'-hydroxysafrole in vivo and in vitro and the electrophilic reactivities of possible ultimate carcinogens.
Wislocki PG, Borchert P, Miller JA, Miller EC. Wislocki PG, et al. Cancer Res. 1976 May;36(5):1686-95. Cancer Res. 1976. PMID: 5188
The electrophilic reactivities of various safrole derivatives with nucleosides were determined to be in the order of 1'-oxosafrole greater than 1'-acetoxysafrole greater than 1'-acetoxysafrole-2',3'-oxide greater than 1'-hydroxysafrole-2',3'-oxide grea …
The electrophilic reactivities of various safrole derivatives with nucleosides were determined to be in the order of 1'-oxosafrole greater t …
Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.
McCann J, Spingarn NE, Kobori J, Ames BN. McCann J, et al. Proc Natl Acad Sci U S A. 1975 Mar;72(3):979-83. doi: 10.1073/pnas.72.3.979. Proc Natl Acad Sci U S A. 1975. PMID: 165497 Free PMC article.
Among these carcinogens are aflatoxin B-1, sterigmatocystin, benzyl chloride, benzo[a]-pyrene, 7,12-dimethylbenzanthracene, 1'-acetoxysafrole, and the nitrofuran food additive furylfuramide (AF-2). ...
Among these carcinogens are aflatoxin B-1, sterigmatocystin, benzyl chloride, benzo[a]-pyrene, 7,12-dimethylbenzanthracene, 1'-ace
N2 atom of guanine and N6 atom of adenine residues as sites for covalent binding of metabolically activated 1'-hydroxysafrole to mouse liver DNA in vivo.
Phillips DH, Miller JA, Miller EC, Adams B. Phillips DH, et al. Cancer Res. 1981 Jul;41(7):2664-71. Cancer Res. 1981. PMID: 7248936
Three of the four in vivo adducts comigrated with adducts formed by reaction of 1'-acetoxysafrole with deoxyguanosine; the fourth adduct comigrated with the major product of the reaction of this ester with deoxyadenosine. ...Adduct II was further characterized from …
Three of the four in vivo adducts comigrated with adducts formed by reaction of 1'-acetoxysafrole with deoxyguanosine; the fou …
Further characterization of the DNA adducts formed by electrophilic esters of the hepatocarcinogens 1'-hydroxysafrole and 1'-hydroxyestragole in vitro and in mouse liver in vivo, including new adducts at C-8 and N-7 of guanine residues.
Wiseman RW, Fennell TR, Miller JA, Miller EC. Wiseman RW, et al. Cancer Res. 1985 Jul;45(7):3096-105. Cancer Res. 1985. PMID: 4005847
The adducts formed from the reactions of 1'-acetoxysafrole or 1'-acetoxyestragole are strictly analogous and are distinguished by the prefixes S and E, respectively. ...Similar levels of these adducts were found in the hepatic DNA after administration of the same do …
The adducts formed from the reactions of 1'-acetoxysafrole or 1'-acetoxyestragole are strictly analogous and are distinguished …
Mutational specificities of 1'-acetoxysafrole, N-benzoyloxy-N-methyl-4-aminoazobenzene, and ethyl methanesulfonate in human cells.
Ingle CA, Drinkwater NR. Ingle CA, et al. Mutat Res. 1989 Mar-May;220(2-3):133-42. doi: 10.1016/0165-1110(89)90019-5. Mutat Res. 1989. PMID: 2927421
We have used an oriP-tk shuttle vector to determine the types of mutations induced in human cells by ethyl methanesulfonate (EMS), 1'-acetoxysafrole (AcOS), and N-benzoyloxy-N-methyl-4-aminoazobenzene (BzOMAB). ...
We have used an oriP-tk shuttle vector to determine the types of mutations induced in human cells by ethyl methanesulfonate (EMS), 1' …
16 results