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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 3
1949 2
1951 1
1952 1
1955 1
1964 4
1966 2
1968 2
1969 1
1970 5
1971 6
1972 4
1973 4
1974 5
1975 5
1976 5
1977 3
1978 6
1979 4
1980 5
1981 8
1982 10
1983 12
1984 12
1985 19
1986 18
1987 22
1988 27
1989 37
1990 36
1991 43
1992 55
1993 77
1994 58
1995 66
1996 68
1997 69
1998 75
1999 76
2000 103
2001 102
2002 89
2003 83
2004 79
2005 110
2006 114
2007 102
2008 121
2009 105
2010 137
2011 131
2012 139
2013 125
2014 130
2015 132
2016 101
2017 129
2018 139
2019 138
2020 149
2021 152
2022 144
2023 143
2024 29

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3,501 results

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Page 1
Cyclobutane based "overbred intermediates" and their exploration in organic synthesis.
Nandy M, Das S, Nanda S. Nandy M, et al. Org Biomol Chem. 2022 Feb 23;20(8):1582-1622. doi: 10.1039/d1ob02361f. Org Biomol Chem. 2022. PMID: 35089299 Review.
This review is based on four-member overbred intermediates (cyclobutane based) that have been used in the total synthesis of natural products from 1968 to 2020. In the initial part, we have discussed synthetic methods (photochemical, metal-mediated, and other miscellaneous …
This review is based on four-member overbred intermediates (cyclobutane based) that have been used in the total synthesis of natural …
Bioactive cyclobutane-containing alkaloids.
Dembitsky VM. Dembitsky VM. J Nat Med. 2008 Jan;62(1):1-33. doi: 10.1007/s11418-007-0166-3. Epub 2007 Sep 5. J Nat Med. 2008. PMID: 18404338 Review.
The present review describes research on novel natural cyclobutane-containing alkaloids and synthetic compounds isolated from terrestrial and marine species. ...Structures, origins, biosynthesis, photodimerization, and biological activities of a selection of cyclobutane
The present review describes research on novel natural cyclobutane-containing alkaloids and synthetic compounds isolated from terrest …
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses.
Yang P, Jia Q, Song S, Huang X. Yang P, et al. Nat Prod Rep. 2023 Jun 21;40(6):1094-1129. doi: 10.1039/d2np00034b. Nat Prod Rep. 2023. PMID: 36314443 Review.
Covering: up to the end of 2021[2 + 2]-Type cyclobutane natural products are biosynthetically derived from intermolecular [2 + 2] cycloaddition or intramolecular [2 + 2] cycloaddition reactions. Due to their distinctive cyclobutane architectures, diverse biological …
Covering: up to the end of 2021[2 + 2]-Type cyclobutane natural products are biosynthetically derived from intermolecular [2 + 2] cyc …
Cyclobutane-type pyrimidine dimers in polynucleotides.
Setlow RB. Setlow RB. Science. 1966 Jul 22;153(3734):379-86. doi: 10.1126/science.153.3734.379. Science. 1966. PMID: 5328566 Review.
The formation of cyclobutane-type dimers between adjacent pyrimidine residues in model polynucleotides or DNA may be represented by the general scheme See pdf 379.pdf Whereas the formation of all other known photoproducts follows the irreversible path See pdf 379.pdf Thus …
The formation of cyclobutane-type dimers between adjacent pyrimidine residues in model polynucleotides or DNA may be represented by t …
Cyclobutane-bearing restricted anchoring residues enabled geometry-specific hydrocarbon peptide stapling.
Chen B, Liu C, Cong W, Gao F, Zou Y, Su L, Liu L, Hillisch A, Lehmann L, Bierer D, Li X, Hu HG. Chen B, et al. Chem Sci. 2023 Sep 29;14(41):11499-11506. doi: 10.1039/d3sc04279k. eCollection 2023 Oct 25. Chem Sci. 2023. PMID: 37886087 Free PMC article.
Usually, stapled peptides are obtained by a hydrocarbon stapling technique, anchoring from paired olefin-terminated unnatural amino acids and the consequent ring-closing metathesis (RCM). To investigate the adaptability of the rigid cyclobutane structure in RCM and expand …
Usually, stapled peptides are obtained by a hydrocarbon stapling technique, anchoring from paired olefin-terminated unnatural amino acids an …
1-Methyl-1-phenyl-3-[1-hydroxyimino-2-(succinimido)ethyl]cyclobutane.
Dinçer M, Ozdemir N, Yilmaz I, Cukurovali A, Büyükgüngör O. Dinçer M, et al. Acta Crystallogr C. 2004 Sep;60(Pt 9):o674-6. doi: 10.1107/S0108270104018074. Epub 2004 Aug 21. Acta Crystallogr C. 2004. PMID: 15345853
In the title compound, C17H20N2O3, the cyclobutane ring is puckered, with a dihedral angle of 19.11 (15) degrees. ...
In the title compound, C17H20N2O3, the cyclobutane ring is puckered, with a dihedral angle of 19.11 (15) degrees. ...
Biological consequences of cyclobutane pyrimidine dimers.
Vink AA, Roza L. Vink AA, et al. J Photochem Photobiol B. 2001 Dec 31;65(2-3):101-4. doi: 10.1016/s1011-1344(01)00245-7. J Photochem Photobiol B. 2001. PMID: 11809365 Review.
In particular, cellular DNA strongly absorbs shorter wavelength solar UV radiation, resulting in various types of DNA damage. Among the DNA photoproducts produced the cyclobutane pyrimidine dimers (CPDs) are predominant. Although these lesions are efficiently repaired in t …
In particular, cellular DNA strongly absorbs shorter wavelength solar UV radiation, resulting in various types of DNA damage. Among the DNA …
Naturally occurring bioactive Cyclobutane-containing (CBC) alkaloids in fungi, fungal endophytes, and plants.
Dembitsky VM. Dembitsky VM. Phytomedicine. 2014 Oct 15;21(12):1559-81. doi: 10.1016/j.phymed.2014.07.005. Epub 2014 Aug 28. Phytomedicine. 2014. PMID: 25442265 Review.
This article focuses on the occurrence and biological activities of cyclobutane-containing (CBC) alkaloids obtained from fungi, fungal endophytes, and plants. ...
This article focuses on the occurrence and biological activities of cyclobutane-containing (CBC) alkaloids obtained from fungi, funga …
Reductive Photocycloreversion of Cyclobutane Dimers Triggered by Guanines.
Rodríguez-Muñiz GM, Fraga-Timiraos AB, Navarrete-Miguel M, Borrego-Sánchez A, Roca-Sanjuán D, Miranda MA, Lhiaubet-Vallet V. Rodríguez-Muñiz GM, et al. J Org Chem. 2023 Jul 21;88(14):10111-10121. doi: 10.1021/acs.joc.3c00930. Epub 2023 Jul 12. J Org Chem. 2023. PMID: 37437138 Free PMC article.
But, in spite of appropriate photoredox properties, the capacity of guanine to repair cyclobutane pyrimidine dimer is not clearly established. Here, dyads containing the cyclobutane thymine dimer and guanine or 8-oxoguanine are synthesized, and their photoreactiviti …
But, in spite of appropriate photoredox properties, the capacity of guanine to repair cyclobutane pyrimidine dimer is not clearly est …
A biorenewable cyclobutane-containing building block synthesized from sorbic acid using photoenergy.
Mabin M, Elliott Q, Wang Z, Ugrinov A, Chu QR. Mabin M, et al. iScience. 2022 Aug 27;25(9):105020. doi: 10.1016/j.isci.2022.105020. eCollection 2022 Sep 16. iScience. 2022. PMID: 36117986 Free PMC article.
A novel cyclobutane-containing diacid building block, CBDA-3, was synthesized from sorbic acid using clean, efficient [2 + 2] photocycloaddition. This photoreaction can be performed using commercially available germicidal lamps, which represent a form of ECO-UV. SC-XRD sho …
A novel cyclobutane-containing diacid building block, CBDA-3, was synthesized from sorbic acid using clean, efficient [2 + 2] photocy …
3,501 results