Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2003 1
2004 1
2007 1
2008 1
2011 4
2012 1
2017 1
2020 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

12 results

Results by year

Filters applied: . Clear all
Page 1
Proposal for a kava quality standardization code.
Teschke R, Lebot V. Teschke R, et al. Food Chem Toxicol. 2011 Oct;49(10):2503-16. doi: 10.1016/j.fct.2011.06.075. Epub 2011 Jul 3. Food Chem Toxicol. 2011. PMID: 21756963 Review.
Their psychoactive, anxiolytic, relaxing, and recreational ingredients are the kavalactones kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin, but there is little evidence that these kavalactones or the non-kavalactones pipermethystine …
Their psychoactive, anxiolytic, relaxing, and recreational ingredients are the kavalactones kavain, dihydrokavain, methysticin, dihydromethy …
Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits.
Teschke R, Qiu SX, Lebot V. Teschke R, et al. Dig Liver Dis. 2011 Sep;43(9):676-81. doi: 10.1016/j.dld.2011.01.018. Epub 2011 Mar 4. Dig Liver Dis. 2011. PMID: 21377431 Review.
In this review, we discuss actual pathogenetic issues of kava hepatotoxicity with special focus on developments regarding pipermethystine, flavokavain B, and mould hepatotoxins as possible culprits. ...Furthermore, in commercial Western kava extracts, pipermethystine …
In this review, we discuss actual pathogenetic issues of kava hepatotoxicity with special focus on developments regarding pipermethystine …
Constituents in kava extracts potentially involved in hepatotoxicity: a review.
Olsen LR, Grillo MP, Skonberg C. Olsen LR, et al. Chem Res Toxicol. 2011 Jul 18;24(7):992-1002. doi: 10.1021/tx100412m. Epub 2011 May 3. Chem Res Toxicol. 2011. PMID: 21506562 Review.
Only a few studies have investigated the toxicity of the minor constituents present in kava extract, such as pipermethystine and the flavokavains, where some have been shown to display higher in vitro cytotoxicity than the lactones. ...
Only a few studies have investigated the toxicity of the minor constituents present in kava extract, such as pipermethystine and the …
Piperidine alkaloids from Piper methysticum.
Dragull K, Yoshida WY, Tang CS. Dragull K, et al. Phytochemistry. 2003 May;63(2):193-8. doi: 10.1016/s0031-9422(03)00111-0. Phytochemistry. 2003. PMID: 12711141
Pipermethystine (1), 3alpha,4alpha-epoxy-5beta-pipermethystine (2) and awaine (3) were isolated from the aerial parts of kava (Piper methysticum G. ...
Pipermethystine (1), 3alpha,4alpha-epoxy-5beta-pipermethystine (2) and awaine (3) were isolated from the aerial parts of kava …
Are mould hepatotoxins responsible for kava hepatotoxicity?
Rowe A, Ramzan I. Rowe A, et al. Phytother Res. 2012 Nov;26(11):1768-70. doi: 10.1002/ptr.4620. Epub 2012 Feb 8. Phytother Res. 2012. PMID: 22319018
Previous studies with kava components such as kavalactones, pipermethystine and flavokavain B have demonstrated hepatotoxicity from these constituents. ...
Previous studies with kava components such as kavalactones, pipermethystine and flavokavain B have demonstrated hepatotoxicity from t …
Kava and kava hepatotoxicity: requirements for novel experimental, ethnobotanical and clinical studies based on a review of the evidence.
Teschke R, Qiu SX, Xuan TD, Lebot V. Teschke R, et al. Phytother Res. 2011 Sep;25(9):1263-74. doi: 10.1002/ptr.3464. Epub 2011 Mar 28. Phytother Res. 2011. PMID: 21442674 Review.
In particular, there is so far no clear evidence for a causative role of kavalactones and non-kavalactone constituents, such as pipermethystine and flavokavain B, identified from kava. Therefore, novel enzymatic, analytical, toxicological, ethnobotanical and clinical studi …
In particular, there is so far no clear evidence for a causative role of kavalactones and non-kavalactone constituents, such as pipermeth …
Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats.
Lim ST, Dragull K, Tang CS, Bittenbender HC, Efird JT, Nerurkar PV. Lim ST, et al. Toxicol Sci. 2007 May;97(1):214-21. doi: 10.1093/toxsci/kfm035. Epub 2007 Feb 27. Toxicol Sci. 2007. PMID: 17329236
It is therefore critical to establish efficacy and verify adverse effects and/or herb-drug interactions for kava-kava (Piper methysticum). We have previously demonstrated that kava alkaloid, pipermethystine (PM), abundant in leaves and stem peelings, induces mitochondrial …
It is therefore critical to establish efficacy and verify adverse effects and/or herb-drug interactions for kava-kava (Piper methysticum). W …
In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones.
Nerurkar PV, Dragull K, Tang CS. Nerurkar PV, et al. Toxicol Sci. 2004 May;79(1):106-11. doi: 10.1093/toxsci/kfh067. Epub 2004 Jan 21. Toxicol Sci. 2004. PMID: 14737001
The aim of this study was to test the in vitro effects of a major kava alkaloid, pipermethystine (PM), found mostly in leaves and stem peelings, and kavalactones such as 7,8-dihydromethysticin (DHM) and desmethoxyyangonin (DMY), which are abundant in the roots. ...
The aim of this study was to test the in vitro effects of a major kava alkaloid, pipermethystine (PM), found mostly in leaves and ste …
Facile enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(1H)-pyridones. First total synthesis of both enantiomers of pipermethystine.
Arrayás RG, Alcudia A, Liebeskind LS. Arrayás RG, et al. Org Lett. 2001 Oct 18;3(21):3381-3. doi: 10.1021/ol010183+. Org Lett. 2001. PMID: 11594839
A novel enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(1H)-pyridones using a ring closing metathesis and a lipase-mediated kinetic resolution as key steps is described and applied to the first synthesis of both enantiomers of pipermethystine....
A novel enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(1H)-pyridones using a ring closing metathesis and a lipase-mediated kinetic res …
12 results