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Heterologous Expression of Mersacidin in Escherichia coli Elucidates the Mode of Leader Processing.
Viel JH, Jaarsma AH, Kuipers OP. Viel JH, et al. ACS Synth Biol. 2021 Mar 19;10(3):600-608. doi: 10.1021/acssynbio.0c00601. Epub 2021 Mar 10. ACS Synth Biol. 2021. PMID: 33689311 Free PMC article.
The lanthipeptide mersacidin is a ribosomally synthesized and post-translationally modified peptide (RiPP) produced by Bacillus amyloliquefaciens. ...Until now, mersacidin and its derivatives have exclusively been produced in Bacillus strains and purified from the s …
The lanthipeptide mersacidin is a ribosomally synthesized and post-translationally modified peptide (RiPP) produced by Bacillus amylo …
Effects of the lantibiotic mersacidin on the morphology of staphylococci.
Molitor E, Kluczny C, Brötz H, Bierbaum G, Jack R, Sahl HG. Molitor E, et al. Zentralbl Bakteriol. 1996 Jul;284(2-3):318-28. doi: 10.1016/s0934-8840(96)80108-3. Zentralbl Bakteriol. 1996. PMID: 8837393
Mersacidin treatment brought about a time-dependent, generalised decrease in the thickness of the bacterial cell wall. In addition, mersacidin treatment caused a roughening of the cell wall surface layer and also reduced the thickness and frequency of formation of d …
Mersacidin treatment brought about a time-dependent, generalised decrease in the thickness of the bacterial cell wall. In addition, …
Mutational Studies of the Mersacidin Leader Reveal the Function of Its Unique Two-Step Leader Processing Mechanism.
Viel JH, Kuipers OP. Viel JH, et al. ACS Synth Biol. 2022 May 20;11(5):1949-1957. doi: 10.1021/acssynbio.2c00088. Epub 2022 May 3. ACS Synth Biol. 2022. PMID: 35504017 Free PMC article.
The dedicated mersacidin transporter and leader protease MrsT was shown to cleave the leader peptide only partially upon export, transporting GDMEAA-mersacidin out of the cell. ...Moreover, by identifying residues and regions that are crucial for mersacidin-t …
The dedicated mersacidin transporter and leader protease MrsT was shown to cleave the leader peptide only partially upon export, tran …
Expression of the lantibiotic mersacidin in Bacillus amyloliquefaciens FZB42.
Herzner AM, Dischinger J, Szekat C, Josten M, Schmitz S, Yakéléba A, Reinartz R, Jansen A, Sahl HG, Piel J, Bierbaum G. Herzner AM, et al. PLoS One. 2011;6(7):e22389. doi: 10.1371/journal.pone.0022389. Epub 2011 Jul 21. PLoS One. 2011. PMID: 21811596 Free PMC article.
Bacillus amyloliquefaciens FZB42 was chosen for these experiments because it already harbors the mersacidin immunity genes. After transfer of the biosynthetic part of the gene cluster by competence transformation, production of active mersacidin was obtained from a …
Bacillus amyloliquefaciens FZB42 was chosen for these experiments because it already harbors the mersacidin immunity genes. After tra …
Modular Use of the Uniquely Small Ring A of Mersacidin Generates the Smallest Ribosomally Produced Lanthipeptide.
Viel JH, Kuipers OP. Viel JH, et al. ACS Synth Biol. 2022 Sep 16;11(9):3078-3087. doi: 10.1021/acssynbio.2c00343. Epub 2022 Sep 5. ACS Synth Biol. 2022. PMID: 36065523 Free PMC article.
However, the formation of unique intramolecular structures like that of mersacidin's ring A can be very stringent. Here, the formation of ring A of mersacidin is characterized by mutagenesis. A range of truncated mersacidin variants was made to identify the s …
However, the formation of unique intramolecular structures like that of mersacidin's ring A can be very stringent. Here, the formatio …
The lantibiotic mersacidin is an autoinducing peptide.
Schmitz S, Hoffmann A, Szekat C, Rudd B, Bierbaum G. Schmitz S, et al. Appl Environ Microbiol. 2006 Nov;72(11):7270-7. doi: 10.1128/AEM.00723-06. Epub 2006 Sep 15. Appl Environ Microbiol. 2006. PMID: 16980420 Free PMC article.
The lantibiotic (lanthionine-containing antibiotic) mersacidin is an antimicrobial peptide consisting of 20 amino acids and is produced by Bacillus sp. strain HIL Y-85,54728. ...To investigate the influence of the alternative sigma factor H on mersacidin biosynthesi …
The lantibiotic (lanthionine-containing antibiotic) mersacidin is an antimicrobial peptide consisting of 20 amino acids and is produc …
Antimicrobial mechanism of lantibiotics.
Islam MR, Nagao J, Zendo T, Sonomoto K. Islam MR, et al. Biochem Soc Trans. 2012 Dec 1;40(6):1528-33. doi: 10.1042/BST20120190. Biochem Soc Trans. 2012. PMID: 23176511 Review.
Type-A(I) (i.e. nisin) and two-component (i.e. lacticin 3147) lantibiotics initially interact with lipid II to stabilize the complex, which then proceeds to inhibit cell wall biosynthesis and pore formation. Type-A(II) (i.e. nukacin ISK-1) and type-B (i.e. mersacidin) lant …
Type-A(I) (i.e. nisin) and two-component (i.e. lacticin 3147) lantibiotics initially interact with lipid II to stabilize the complex, which …
Characterization of Leader Processing Shows That Partially Processed Mersacidin Is Activated by AprE After Export.
Viel JH, van Tilburg AY, Kuipers OP. Viel JH, et al. Front Microbiol. 2021 Oct 28;12:765659. doi: 10.3389/fmicb.2021.765659. eCollection 2021. Front Microbiol. 2021. PMID: 34777321 Free PMC article.
The ribosomally synthesized and post-translationally modified peptide mersacidin is a class II lanthipeptide with good activity against Gram-positive bacteria. ...To add the mersacidin modification enzymes to the synthetic biology toolbox, a heterologous expression …
The ribosomally synthesized and post-translationally modified peptide mersacidin is a class II lanthipeptide with good activity again …
The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation.
Brötz H, Bierbaum G, Reynolds PE, Sahl HG. Brötz H, et al. Eur J Biochem. 1997 May 15;246(1):193-9. doi: 10.1111/j.1432-1033.1997.t01-1-00193.x. Eur J Biochem. 1997. PMID: 9210483 Free article.
The lantibiotic mersacidin has been previously reported to interfere with bacterial peptidoglycan biosynthesis, [Brotz, H., Bierbaum, G., Markus, A., Molitor, E. & Sahl, H....The analogy to the glycopeptides may hint at an interaction of mersacidin with the pept …
The lantibiotic mersacidin has been previously reported to interfere with bacterial peptidoglycan biosynthesis, [Brotz, H., Bierbaum, …
Dissecting structural and functional diversity of the lantibiotic mersacidin.
Appleyard AN, Choi S, Read DM, Lightfoot A, Boakes S, Hoffmann A, Chopra I, Bierbaum G, Rudd BA, Dawson MJ, Cortes J. Appleyard AN, et al. Chem Biol. 2009 May 29;16(5):490-8. doi: 10.1016/j.chembiol.2009.03.011. Chem Biol. 2009. PMID: 19477413 Free PMC article.
Mersacidin is a tetracyclic lantibiotic with antibacterial activity against Gram-positive pathogens. ...Mersacidin analogs were obtained in good yield in approximately 35% of the cases, producing a collection of 82 new compounds. ...
Mersacidin is a tetracyclic lantibiotic with antibacterial activity against Gram-positive pathogens. ...Mersacidin analogs wer …
91 results