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2011 | 1 |
2021 | 1 |
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Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis.
Chem Biol Interact. 2011 Nov 15;194(2-3):91-6. doi: 10.1016/j.cbi.2011.09.001. Epub 2011 Sep 9.
Chem Biol Interact. 2011.
PMID: 21930118
One challenge is the reactivation of OP-inhibited brain AChE which shows inadequate success with charged pyridinium oximes. Recent studies with high doses of the tertiary oxime isonitrosoacetone (MINA) indicated a beneficial effect on central and peripheral AChE and on sur …
One challenge is the reactivation of OP-inhibited brain AChE which shows inadequate success with charged pyridinium oximes. Recent studies w …
The tertiary oxime monoisonitrosoacetone penetrates the brain, reactivates inhibited acetylcholinesterase, and reduces mortality and morbidity following lethal sarin intoxication in guinea pigs.
Shih TM, Oyler BL, Capacio BR, Koplovitz I.
Shih TM, et al.
Toxicol Appl Pharmacol. 2021 Mar 15;415:115443. doi: 10.1016/j.taap.2021.115443. Epub 2021 Feb 4.
Toxicol Appl Pharmacol. 2021.
PMID: 33548273
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