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Iberverin exhibits antineoplastic activities against human hepatocellular carcinoma via DNA damage-mediated cell cycle arrest and mitochondrial-related apoptosis.
Zhang Y, Du J, Jin L, Pan L, Yan X, Lin S. Zhang Y, et al. Front Pharmacol. 2023 Dec 13;14:1326346. doi: 10.3389/fphar.2023.1326346. eCollection 2023. Front Pharmacol. 2023. PMID: 38152688 Free PMC article.
However, the roles of iberverin in HCC remain elusive. In the present study, the effect and potential mechanisms of iberverin against human HCC were dissected. ...Furthermore, we found that iberverin treatment induced DNA damage and G2/M phase arrest. Iber …
However, the roles of iberverin in HCC remain elusive. In the present study, the effect and potential mechanisms of iberverin …
Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin.
Ernst IM, Palani K, Esatbeyoglu T, Schwarz K, Rimbach G. Ernst IM, et al. Pharmacol Res. 2013 Apr;70(1):155-62. doi: 10.1016/j.phrs.2013.01.011. Epub 2013 Feb 9. Pharmacol Res. 2013. PMID: 23403058
Therefore, in this study we synthesized the isothiocyanates iberverin, iberin and cheirolin with a high yield and purity and determined their Nrf2-inducing activity in NIH3T3 fibroblasts. Iberverin, iberin and cheirolin significantly induced Nrf2 nuclear translocati …
Therefore, in this study we synthesized the isothiocyanates iberverin, iberin and cheirolin with a high yield and purity and determin …
In Vitro Anti-Leishmanial Activity of Glucosinolate Fraction from Alyssum linifolium Steph. ex Willd (Brassicaceae).
Mirzaee F, Faridnia R, Fakhar M, Kalani H, Shahani S. Mirzaee F, et al. Turk J Pharm Sci. 2023 Mar 2;20(1):16-22. doi: 10.4274/tjps.galenos.2022.78027. Turk J Pharm Sci. 2023. PMID: 36862022 Free PMC article.
Glucoiberverin was the major constituent of the GSL fraction characterized using nuclear magnetic resonance and electron ionization-mass spectrometry spectra. Based on gas chromatography-mass spectrometry data, iberverin and iberverin nitrile, the hydrolysis constit …
Glucoiberverin was the major constituent of the GSL fraction characterized using nuclear magnetic resonance and electron ionization-mass spe …
Induction of the Stringent Response Underlies the Antimicrobial Action of Aliphatic Isothiocyanates.
Nowicki D, Krause K, Szamborska P, Żukowska A, Cech GM, Szalewska-Pałasz A. Nowicki D, et al. Front Microbiol. 2021 Jan 14;11:591802. doi: 10.3389/fmicb.2020.591802. eCollection 2020. Front Microbiol. 2021. PMID: 33584562 Free PMC article.
In this work, we asked whether ITCs could act synergistically with each other to increase the antibacterial effect. A set of aliphatic ITCs, such as iberin, iberverin, alyssin, erucin, sulforaphen, erysolin, and cheirolin was tested in combination with sulforaphane against …
In this work, we asked whether ITCs could act synergistically with each other to increase the antibacterial effect. A set of aliphatic ITCs, …
The Molecular Basis of Host Selection in a Crucifer-Specialized Moth.
Liu XL, Zhang J, Yan Q, Miao CL, Han WK, Hou W, Yang K, Hansson BS, Peng YC, Guo JM, Xu H, Wang CZ, Dong SL, Knaden M. Liu XL, et al. Curr Biol. 2020 Nov 16;30(22):4476-4482.e5. doi: 10.1016/j.cub.2020.08.047. Epub 2020 Sep 10. Curr Biol. 2020. PMID: 32916118 Free article.
By ectopically expressing these Ors in Xenopus oocytes and screening their responses with 49 odors (including 13 ITCs, 25 general plant volatiles, and 11 sex pheromone components), we found that Or35 and Or49 responded specifically to three ITCs (iberverin, 4-pentenyl ITC, …
By ectopically expressing these Ors in Xenopus oocytes and screening their responses with 49 odors (including 13 ITCs, 25 general plant vola …
The metabolism of methylsulfinylalkyl- and methylthioalkyl-glucosinolates by a selection of human gut bacteria.
Luang-In V, Narbad A, Nueno-Palop C, Mithen R, Bennett M, Rossiter JT. Luang-In V, et al. Mol Nutr Food Res. 2014 Apr;58(4):875-83. doi: 10.1002/mnfr.201300377. Epub 2013 Oct 30. Mol Nutr Food Res. 2014. PMID: 24170324
Interestingly, Escherichia coli VL8 metabolized 80-90% of glucoiberin and glucoraphanin and also bioconverted glucoraphanin and glucoiberin to glucoerucin and glucoiberverin, respectively, producing erucin, erucin NIT, iberverin, and iberverin NIT from the two GSLs. …
Interestingly, Escherichia coli VL8 metabolized 80-90% of glucoiberin and glucoraphanin and also bioconverted glucoraphanin and glucoiberin …
African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals properties.
Rahmani R, Bouajila J, Jouaidi M, Debouba M. Rahmani R, et al. J Food Sci. 2020 Jun;85(6):1856-1871. doi: 10.1111/1750-3841.15157. Epub 2020 May 31. J Food Sci. 2020. PMID: 32476145
Interestingly, gas chromatograph-y-mass spectrometry (GC-MS) analysis enabled to identify three new isothiocyanates: iberverin nitrile and iberin detected only in roots, and iberin nitrile detected in all organs. ...
Interestingly, gas chromatograph-y-mass spectrometry (GC-MS) analysis enabled to identify three new isothiocyanates: iberverin nitril …
Exploration of the Biocontrol Activity of Bacillus atrophaeus Strain HF1 against Pear Valsa Canker Caused by Valsa pyri.
Yuan H, Shi B, Wang Z, Qin G, Hou H, Tu H, Wang L. Yuan H, et al. Int J Mol Sci. 2023 Oct 23;24(20):15477. doi: 10.3390/ijms242015477. Int J Mol Sci. 2023. PMID: 37895155 Free PMC article.
Headspace mixtures prepared from strain HF1 were analyzed, leading to the identification of 27 potential VOCs. Of the thirteen pure chemicals tested, iberverin, hexanoic acid, and 2-methylvaleraldehyde exhibited the strongest antifungal effects on V. pyri, with respective …
Headspace mixtures prepared from strain HF1 were analyzed, leading to the identification of 27 potential VOCs. Of the thirteen pure chemical …
Lactic acid bacteria convert glucosinolates to nitriles efficiently yet differently from enterobacteriaceae.
Mullaney JA, Kelly WJ, McGhie TK, Ansell J, Heyes JA. Mullaney JA, et al. J Agric Food Chem. 2013 Mar 27;61(12):3039-46. doi: 10.1021/jf305442j. Epub 2013 Mar 15. J Agric Food Chem. 2013. PMID: 23461529
Enterobacteriaceae consumed on average 65% glucoiberin and 78% glucoraphanin, transforming them into glucoiberverin and glucoerucin, respectively, and small amounts of iberverin nitrile and erucin nitrile. The lactic acid bacteria did not accumulate reduced glucosinolates, …
Enterobacteriaceae consumed on average 65% glucoiberin and 78% glucoraphanin, transforming them into glucoiberverin and glucoerucin, respect …
Inhibition of growth and induction of apoptosis in A549 cells by compounds from oxheart cabbage extract.
Wang N, Wang W, Liu C, Jin J, Shao B, Shen L. Wang N, et al. J Sci Food Agric. 2016 Aug;96(11):3813-20. doi: 10.1002/jsfa.7575. Epub 2016 Feb 16. J Sci Food Agric. 2016. PMID: 26679410
RESULTS: The cytotoxicity and apoptotic effects of fraction II, fraction III, iberverin, sulforaphane and iberin from oxheart cabbage seed extract were investigated. ...Fraction II, fraction III, iberverin, sulforaphane and iberin induced cell apoptosis by increasin …
RESULTS: The cytotoxicity and apoptotic effects of fraction II, fraction III, iberverin, sulforaphane and iberin from oxheart cabbage …
13 results