Structurally modified natural sesquiterpene lactones constitute effective and less toxic schistosomicidal compounds.
Sass DC, Morais GO, Miranda RA, Magalhães LG, Cunha WR, dos Santos RA, Arakawa NS, Da Costa FB, Constantino MG, Heleno VC.
Sass DC, et al.
Org Biomol Chem. 2014 Oct 28;12(40):7957-64. doi: 10.1039/c4ob00426d.
Org Biomol Chem. 2014.
PMID: 25030079
More specifically, we assessed the activity of budlein-A, a furanoheliangolide sesquiterpene lactone, and four of its derivatives. The structural modifications of budlein-A, presented in this work, diminished the cytotoxicity and changed the antiparasitary behavior of the …
More specifically, we assessed the activity of budlein-A, a furanoheliangolide sesquiterpene lactone, and four of its derivatives. Th …