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2003 2
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Page 1
The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth.
Pant K, Richard S, Peixoto E, Yin J, Seelig DM, Carotenuto P, Salati M, Franco B, Roberts LR, Gradilone SA. Pant K, et al. Cells. 2023 Feb 28;12(5):775. doi: 10.3390/cells12050775. Cells. 2023. PMID: 36899911 Free PMC article.
Previous research has shown that the targeted NAMPT inhibitor FK866 reduces cancer cell viability and triggers cancer cell death; however, whether FK866 affects CCA cell survival has not been addressed before. ...The present study's findings further show that FK8 …
Previous research has shown that the targeted NAMPT inhibitor FK866 reduces cancer cell viability and triggers cancer cell death; how …
FK866 attenuates sepsis-induced acute lung injury through c-jun-N-terminal kinase (JNK)-dependent autophagy.
Zheng Q, Wang YC, Liu QX, Dong XJ, Xie ZX, Liu XH, Gao W, Bai XJ, Li ZF. Zheng Q, et al. Life Sci. 2020 Jun 1;250:117551. doi: 10.1016/j.lfs.2020.117551. Epub 2020 Mar 13. Life Sci. 2020. PMID: 32179075
However, the contribution of autophagy and the underlying mechanism by which FK866-confered lung protection remains elusive. Herein, we aimed to study whether FK866 could alleviate sepsis-induced ALI via the JNK-dependent autophagy. ...SIGNIFICANCE: Our study indica …
However, the contribution of autophagy and the underlying mechanism by which FK866-confered lung protection remains elusive. Herein, …
FK866 inhibits colorectal cancer metastasis by reducing NAD(+) levels in cancer-associated fibroblasts.
Xie H, Lei Y, Mao Y, Lan J, Yang J, Quan H, Zhang T. Xie H, et al. Genes Genomics. 2022 Dec;44(12):1531-1541. doi: 10.1007/s13258-022-01318-w. Epub 2022 Oct 10. Genes Genomics. 2022. PMID: 36214983
OBJECTIVE: This study sought to explore the molecular mechanism of FK866 in CAFs cell and colorectal cancer proliferation and metastasis. ...Meanwhile, FK866 treatment inhibits the migration ability of SW480 cells co-cultured with CAFs. ...
OBJECTIVE: This study sought to explore the molecular mechanism of FK866 in CAFs cell and colorectal cancer proliferation and metasta …
NAD metabolism fuels human and mouse intestinal inflammation.
Gerner RR, Klepsch V, Macheiner S, Arnhard K, Adolph TE, Grander C, Wieser V, Pfister A, Moser P, Hermann-Kleiter N, Baier G, Oberacher H, Tilg H, Moschen AR. Gerner RR, et al. Gut. 2018 Oct;67(10):1813-1823. doi: 10.1136/gutjnl-2017-314241. Epub 2017 Sep 6. Gut. 2018. PMID: 28877980 Free PMC article.
RESULTS: FK866 ameliorated DSS-induced colitis and suppressed inflammation-associated tumorigenesis in mice. ...Remarkably, FK866 effectively supressed cytokine release from LPMNCs of patients with IBD. ...
RESULTS: FK866 ameliorated DSS-induced colitis and suppressed inflammation-associated tumorigenesis in mice. ...Remarkably, FK866 …
FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy.
Guo E, Li R, Yang J, Zhang J, Li A, Yang Y, Liu S, Liu A, Jiang X. Guo E, et al. Sci Rep. 2017 May 19;7(1):2206. doi: 10.1038/s41598-017-02318-7. Sci Rep. 2017. PMID: 28526886 Free PMC article.
FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated. ...In vivo, Mice were pretreated wit …
FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver f …
FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence.
Ok CY, Park S, Jang HO, Takata T, Lee OH, Bae MK, Bae SK. Ok CY, et al. Antioxidants (Basel). 2021 Feb 10;10(2):271. doi: 10.3390/antiox10020271. Antioxidants (Basel). 2021. PMID: 33578781 Free PMC article.
FK866 possesses various functional properties, such as anti-angiogenic, anti-cancer, and anti-inflammatory activities. ...The present study aimed to investigate whether H(2)O(2)-induced premature senescence of hDPCs is affected by treatment with FK866. We found that …
FK866 possesses various functional properties, such as anti-angiogenic, anti-cancer, and anti-inflammatory activities. ...The present …
Lipopolysaccharide-Induced Microglial Neuroinflammation: Attenuation by FK866.
Xu Y, Yu L, Liu Y, Tang X, Wang X. Xu Y, et al. Neurochem Res. 2021 May;46(5):1291-1304. doi: 10.1007/s11064-021-03267-4. Epub 2021 Mar 13. Neurochem Res. 2021. PMID: 33713324
FK866 also significantly inhibited LPS-induced polarization change in microglia. ...Finally, conditioned medium from microglia cultures co-treated with FK866 and LPS significantly increased SH-SY5Y and PC12 cell viability compared with conditioned medium from microg …
FK866 also significantly inhibited LPS-induced polarization change in microglia. ...Finally, conditioned medium from microglia cultur …
FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes.
Oyarzún AP, Westermeier F, Pennanen C, López-Crisosto C, Parra V, Sotomayor-Flores C, Sánchez G, Pedrozo Z, Troncoso R, Lavandero S. Oyarzún AP, et al. Biochem Pharmacol. 2015 Nov 1;98(1):92-101. doi: 10.1016/j.bcp.2015.08.097. Epub 2015 Aug 20. Biochem Pharmacol. 2015. PMID: 26297909
Using FK866 to target NAD(+) synthesis has been proposed as a treatment for inflammatory diseases and cancer. ...METHODS AND RESULTS: FK866 was used to deplete NAD(+) levels in cultured rat cardiomyocytes. ...
Using FK866 to target NAD(+) synthesis has been proposed as a treatment for inflammatory diseases and cancer. ...METHODS AND RESULTS: …
Neuroprotective effects of FK866 against traumatic brain injury: Involvement of p38/ERK pathway.
Tan Z, Chen L, Ren Y, Jiang X, Gao W. Tan Z, et al. Ann Clin Transl Neurol. 2020 May;7(5):742-756. doi: 10.1002/acn3.51044. Epub 2020 Apr 17. Ann Clin Transl Neurol. 2020. PMID: 32302063 Free PMC article.
However, in traumatic brain injury (TBI), the role and mechanism of FK866 remain unclear. The present research was aimed to investigate whether FK866 could attenuate TBI and clarified the underlying mechanisms. ...Moreover, p38 MAPK and ERK activation were significa …
However, in traumatic brain injury (TBI), the role and mechanism of FK866 remain unclear. The present research was aimed to investiga …
FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells.
Zhang B, Shi D, Zhang X, Liang G, Liu W, Qiao S. Zhang B, et al. Oncol Lett. 2018 Dec;16(6):7231-7238. doi: 10.3892/ol.2018.9541. Epub 2018 Oct 3. Oncol Lett. 2018. PMID: 30546461 Free PMC article.
Furthermore, FK866 markedly decreased NAD+ and adenosine 5'-triphosphate content in MHCC97-H cells by inhibiting NAMPT expression. ...Furthermore, FK866 inhibited the SIRT1-mediated EMT, invasion and migration of HCC cells by decreasing the expression of the NAMPT/N …
Furthermore, FK866 markedly decreased NAD+ and adenosine 5'-triphosphate content in MHCC97-H cells by inhibiting NAMPT expression. .. …
298 results

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