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1980 3
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186 results

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Page 1
Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.
Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH. Baik AH, et al. Mol Cell. 2023 Mar 16;83(6):942-960.e9. doi: 10.1016/j.molcel.2023.02.013. Epub 2023 Mar 8. Mol Cell. 2023. PMID: 36893757 Free PMC article.
We find that hyperoxia destabilizes a specific subset of Fe-S cluster (ISC)-containing proteins, resulting in impaired diphthamide synthesis, purine metabolism, nucleotide excision repair, and electron transport chain (ETC) function. ...
We find that hyperoxia destabilizes a specific subset of Fe-S cluster (ISC)-containing proteins, resulting in impaired diphthamide sy …
The diphthamide modification pathway from Saccharomyces cerevisiae--revisited.
Schaffrath R, Abdel-Fattah W, Klassen R, Stark MJ. Schaffrath R, et al. Mol Microbiol. 2014 Dec;94(6):1213-26. doi: 10.1111/mmi.12845. Epub 2014 Nov 17. Mol Microbiol. 2014. PMID: 25352115 Free article. Review.
Diphthamide is a conserved modification in archaeal and eukaryal translation elongation factor 2 (EF2). ...Although this clearly emphasizes a pathobiological role for diphthamide, its physiological function is unclear, and precisely why cells need EF2 to contain …
Diphthamide is a conserved modification in archaeal and eukaryal translation elongation factor 2 (EF2). ...Although this clearly emph …
ADP-ribosylation.
Ueda K, Hayaishi O. Ueda K, et al. Annu Rev Biochem. 1985;54:73-100. doi: 10.1146/annurev.bi.54.070185.000445. Annu Rev Biochem. 1985. PMID: 3927821 Review. No abstract available.
The biosynthesis and biological function of diphthamide.
Su X, Lin Z, Lin H. Su X, et al. Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):515-21. doi: 10.3109/10409238.2013.831023. Epub 2013 Aug 23. Crit Rev Biochem Mol Biol. 2013. PMID: 23971743 Free PMC article. Review.
Eukaryotic and archaeal elongation factor 2 contains a unique post-translationally modified histidine residue, named diphthamide. Genetic and biochemical studies have revealed that diphthamide biosynthesis involves a multi-step pathway that is evolutionally conserve …
Eukaryotic and archaeal elongation factor 2 contains a unique post-translationally modified histidine residue, named diphthamide. Gen …
Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis.
Robinson KS, Toh GA, Firdaus MJ, Tham KC, Rozario P, Lim CK, Toh YX, Lau ZH, Binder SC, Mayer J, Bonnard C, Schmidt FI, Common JEA, Zhong FL. Robinson KS, et al. J Exp Med. 2023 Oct 2;220(10):e20230105. doi: 10.1084/jem.20230105. Epub 2023 Aug 29. J Exp Med. 2023. PMID: 37642997 Free PMC article.
This process requires iron-mediated DT production in the bacteria, as well as diphthamide synthesis and ZAKalpha/p38-driven NLRP1 phosphorylation in host cells. ...
This process requires iron-mediated DT production in the bacteria, as well as diphthamide synthesis and ZAKalpha/p38-driven NLRP1 pho …
Diphthamide - a conserved modification of eEF2 with clinical relevance.
Schaffrath R, Brinkmann U. Schaffrath R, et al. Trends Mol Med. 2024 Feb;30(2):164-177. doi: 10.1016/j.molmed.2023.11.008. Epub 2023 Dec 13. Trends Mol Med. 2024. PMID: 38097404 Free article. Review.
Diphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. ...
Diphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during trans …
Tagraxofusp in myeloid malignancies.
Bruzzese A, Martino EA, Labanca C, Mendicino F, Lucia E, Olivito V, Neri A, Imovilli A, Morabito F, Vigna E, Gentile M. Bruzzese A, et al. Hematol Oncol. 2024 Jan;42(1):e3234. doi: 10.1002/hon.3234. Epub 2023 Oct 17. Hematol Oncol. 2024. PMID: 37846131 Review.
Furthermore, combination strategies may be used to overcome tagraxofusp resistance. The downregulation of DPH1 (diphthamide biosynthesis 1), the enzyme responsible for the conversion of histidine 715 on eEF2 to diphthamide, which is then the direct target of ADP rib …
Furthermore, combination strategies may be used to overcome tagraxofusp resistance. The downregulation of DPH1 (diphthamide biosynthe …
eEF2 diphthamide modification restrains spurious frameshifting to maintain translational fidelity.
Shin BS, Ivanov IP, Kim JR, Cao C, Kinzy TG, Dever TE. Shin BS, et al. Nucleic Acids Res. 2023 Jul 21;51(13):6899-6913. doi: 10.1093/nar/gkad461. Nucleic Acids Res. 2023. PMID: 37246715 Free PMC article.
Diphthamide (DPH), a conserved amino acid modification on eukaryotic translation elongation factor eEF2, is synthesized via a complex, multi-enzyme pathway. ...
Diphthamide (DPH), a conserved amino acid modification on eukaryotic translation elongation factor eEF2, is synthesized via a complex …
Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress.
Mayer K, Mundigl O, Kettenberger H, Birzele F, Stahl S, Pastan I, Brinkmann U. Mayer K, et al. Redox Biol. 2019 Jan;20:146-156. doi: 10.1016/j.redox.2018.09.015. Epub 2018 Sep 26. Redox Biol. 2019. PMID: 30312900 Free PMC article.
Nevertheless, cells lacking diphthamide can carry out protein synthesis and are viable. We have analyzed the phenotypes of diphthamide deficient cells and found that diphthamide deficiency reduces selenocysteine incorporation into selenoproteins. ...Involveme …
Nevertheless, cells lacking diphthamide can carry out protein synthesis and are viable. We have analyzed the phenotypes of diphtha …
Moxetumomab Pasudotox: First Global Approval.
Dhillon S. Dhillon S. Drugs. 2018 Nov;78(16):1763-1767. doi: 10.1007/s40265-018-1000-9. Drugs. 2018. PMID: 30357593 Free PMC article. Review.
Once internalised, PE38 catalyses the ADP ribosylation of the diphthamide residue in elongation factor-2 (EF-2), resulting in the rapid fall in levels of the anti-apoptotic protein myeloid cell leukaemia 1 (Mcl-1), leading to apoptotic cell death. ...
Once internalised, PE38 catalyses the ADP ribosylation of the diphthamide residue in elongation factor-2 (EF-2), resulting in the rap …
186 results