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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1969 1
1971 1
1972 1
1974 4
1976 3
1977 3
1978 7
1979 2
1981 3
1982 2
1983 2
1984 10
1985 6
1986 1
1987 6
1988 6
1989 6
1990 6
1991 8
1992 7
1993 7
1994 12
1995 13
1996 20
1997 13
1998 21
1999 16
2000 29
2001 23
2002 38
2003 26
2004 55
2005 52
2006 54
2007 68
2008 84
2009 123
2010 129
2011 90
2012 100
2013 102
2014 110
2015 97
2016 94
2017 98
2018 93
2019 108
2020 108
2021 109
2022 104
2023 83
2024 48

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1,988 results

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Page 1
HPMA copolymer-cyclic RGD conjugates for tumor targeting.
Pike DB, Ghandehari H. Pike DB, et al. Adv Drug Deliv Rev. 2010 Feb 17;62(2):167-83. doi: 10.1016/j.addr.2009.11.027. Epub 2009 Dec 4. Adv Drug Deliv Rev. 2010. PMID: 19951733 Review.
This review describes the design and development of N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymer-cyclic RGD conjugates for targeting tumor angiogenesis. Relative to non-targetable systems, HPMA copolymer-RGD4C and -RGDfK conjugates have shown increased tumor …
This review describes the design and development of N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymer-cyclic RGD conjugates for tar …
Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities.
Duncan R, Vicent MJ. Duncan R, et al. Adv Drug Deliv Rev. 2010 Feb 17;62(2):272-82. doi: 10.1016/j.addr.2009.12.005. Epub 2009 Dec 11. Adv Drug Deliv Rev. 2010. PMID: 20005271 Review.
Early clinical results were promising, confirming activity in chemotherapy refractory patients and the safety of HPMA copolymers as a new polymer platform in this setting. Subsequent Phase I/II trials have investigated conjugates containing paclitaxel (PNU 166945), camptot …
Early clinical results were promising, confirming activity in chemotherapy refractory patients and the safety of HPMA copolymers as a …
Covalent anionic copolymer coatings with tunable electroosmotic flow for optimization of capillary electrophoretic separations.
Šolínová V, Tůma P, Butnariu M, Kašička V, Koval D. Šolínová V, et al. Electrophoresis. 2022 Oct;43(20):1953-1962. doi: 10.1002/elps.202200130. Epub 2022 Sep 6. Electrophoresis. 2022. PMID: 35986681
To this end, we use surface modification of the separation fused silica capillary by the covalently attached copolymer of acrylamide (AM) and 2-acrylamido-2-methyl-1-propanesulfonate (AMPS), that is, poly(AM-co-AMPS) or PAMAMPS. Coatings were formed by the in-capill …
To this end, we use surface modification of the separation fused silica capillary by the covalently attached copolymer of acrylami …
Revisiting Protein-Copolymer Binding Mechanisms: Insights beyond the "Lock-and-Key" Model.
Xu X, Xie M, Luo S, Jia X. Xu X, et al. J Phys Chem Lett. 2024 Jan 25;15(3):773-781. doi: 10.1021/acs.jpclett.3c03200. Epub 2024 Jan 16. J Phys Chem Lett. 2024. PMID: 38227953
The "lock-and-key" model that emphasizes the concept of chemical-structural complementary is the key mechanism for explaining the selectivity between small ligands and a larger adsorbent molecule. In this work, concerning the copolymer chain using only the combination of N …
The "lock-and-key" model that emphasizes the concept of chemical-structural complementary is the key mechanism for explaining the selectivit …
HPMA copolymers: 30 years of advances.
Lammers T, Ulbrich K. Lammers T, et al. Adv Drug Deliv Rev. 2010 Feb 17;62(2):119-21. doi: 10.1016/j.addr.2009.12.004. Epub 2009 Dec 11. Adv Drug Deliv Rev. 2010. PMID: 20005273 No abstract available.
Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations.
Lammers T. Lammers T. Adv Drug Deliv Rev. 2010 Feb 17;62(2):203-30. doi: 10.1016/j.addr.2009.11.028. Epub 2009 Dec 4. Adv Drug Deliv Rev. 2010. PMID: 19951732 Review.
Copolymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that have been broadly implemented in the delivery of anticancer agents. HPMA copolymers circulate for prolonged periods of time, and by means …
Copolymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that have …
Tumor targeting HPMA-porphyrin-99mTc copolymer molecular imaging agent.
Yuan L, Ma Y, Yuan J. Yuan L, et al. J Biomater Sci Polym Ed. 2014;25(18):2066-79. doi: 10.1080/09205063.2014.970064. Epub 2014 Oct 15. J Biomater Sci Polym Ed. 2014. PMID: 25315509
To investigate the relative importance of active and passive targeting strategies, the synthesis, characterization, in vitro uptake, and in vivo biodistribution of specific targeting porphyrin HPMA [HPMA: N-(2-hydroxypropyl)methacrylamide] copolymer tracer poly(HPMA)-porph …
To investigate the relative importance of active and passive targeting strategies, the synthesis, characterization, in vitro uptake, and in …
The synthesis of an acrylamide copolymer and its synergistic effects on clay flocculation of red tide organisms.
Yu Q, Yu Z, Song X, Cao X, Jiang W, Chu Y. Yu Q, et al. J Environ Manage. 2023 Apr 15;332:117326. doi: 10.1016/j.jenvman.2023.117326. Epub 2023 Feb 8. J Environ Manage. 2023. PMID: 36764213
The modified clay (MC) method is a common emergency treatment technology for red tides, and the selection of surface modifiers is the key to the MC technology. A cationic polymeric modifier, the copolymer of dimethyl diallyl ammonium chloride and acrylamide (P (DMDA …
The modified clay (MC) method is a common emergency treatment technology for red tides, and the selection of surface modifiers is the key to …
Gradient Polymerization-Induced Self-Assembly: A One-Step Approach.
Xu S, Zhang T, Kuchel RP, Yeow J, Boyer C. Xu S, et al. Macromol Rapid Commun. 2020 Jan;41(1):e1900493. doi: 10.1002/marc.201900493. Epub 2019 Nov 10. Macromol Rapid Commun. 2020. PMID: 31709698
In contrast to conventional approaches employing a pre-formed macromolecular stabilizer, the disparate reactivities between two monomers, oligo(ethylene glycol) methyl ether methacrylate (OEGMA) and diacetone acrylamide (DAAm), are exploited instead to synthesize a gradien …
In contrast to conventional approaches employing a pre-formed macromolecular stabilizer, the disparate reactivities between two monomers, ol …
pH-triggered block copolymer micelle-to-micelle phase transition.
Xu L, Zhu Z, Borisov OV, Zhulina EB, Sukhishvili SA. Xu L, et al. Phys Rev Lett. 2009 Sep 11;103(11):118301. doi: 10.1103/PhysRevLett.103.118301. Epub 2009 Sep 9. Phys Rev Lett. 2009. PMID: 19792404
We present a first experimental observation and provide a theoretical interpretation of a pH-induced micelle-to-micelle phase transition in aqueous solutions of spherical block copolymer micelles with polybasic coronas. Dynamic light scattering, static light scattering, an …
We present a first experimental observation and provide a theoretical interpretation of a pH-induced micelle-to-micelle phase transition in …
1,988 results