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Widdrol-induced lipolysis is mediated by PKC and MEK/ERK in 3T3-L1 adipocytes.
Jeong HY, Yun HJ, Kim BW, Lee EW, Kwon HJ. Jeong HY, et al. Mol Cell Biochem. 2015 Dec;410(1-2):247-54. doi: 10.1007/s11010-015-2558-0. Epub 2015 Sep 10. Mol Cell Biochem. 2015. PMID: 26359088
In the present study, we investigated the lipolytic effect of widdrol in 3T3-L1 adipocytes and its mechanism. Widdrol considerably increased the amount of glycerol released from 3T3-L1 adipocytes into the medium in a time- and dose-dependent manner. ...These results …
In the present study, we investigated the lipolytic effect of widdrol in 3T3-L1 adipocytes and its mechanism. Widdrol consider …
Widdrol blocks 3T3-L1 preadipocytes growth and differentiation due to inhibition of mitotic clonal expansion.
Yun HJ, Kim JH, Jeong HY, Ji HH, Nam SW, Lee EW, Kim BW, Kwon HJ. Yun HJ, et al. J Microbiol Biotechnol. 2012 Jun;22(6):806-13. doi: 10.4014/jmb.1110.10039. J Microbiol Biotechnol. 2012. PMID: 22573158 Free article.
Adipocyte differentiation is strongly associated with obesity, which causes metabolic disorders. In this study, we investigated the inhibitory effects of widdrol on 3T3- L1 preadipocyte growth and differentiation. Widdrol decreased lipid droplet accumulation and dow …
Adipocyte differentiation is strongly associated with obesity, which causes metabolic disorders. In this study, we investigated the inhibito …
Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells.
Yun HJ, Hyun SK, Park JH, Kim BW, Kwon HJ. Yun HJ, et al. Mol Cell Biochem. 2012 Apr;363(1-2):281-9. doi: 10.1007/s11010-011-1180-z. Epub 2011 Dec 11. Mol Cell Biochem. 2012. PMID: 22160829
Widdrol is an odorant compound isolated from Juniperus chinensis. ...First of all, we examined that widdrol breaks DNA directly or not. As the results of DNA electrophoresis and formation of phosphorylated histone H2AX (gammaH2AX) foci in HT29 cells, widdrol …
Widdrol is an odorant compound isolated from Juniperus chinensis. ...First of all, we examined that widdrol breaks DNA directl …
Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells.
Kang MR, Park SK, Lee CW, Cho IJ, Jo YN, Yang JW, Kim JA, Yun J, Lee KH, Kwon HJ, Kim BW, Lee K, Kang JS, Kim HM. Kang MR, et al. Oncol Rep. 2012 May;27(5):1407-12. doi: 10.3892/or.2012.1644. Epub 2012 Jan 19. Oncol Rep. 2012. PMID: 22266984
We showed that widdrol induced the phosphorylation of AMPK in a dose- and time-dependent manner. ...Furthermore, widdrol inhibited HT-29 tumor growth in a human tumor xenograft model. ...
We showed that widdrol induced the phosphorylation of AMPK in a dose- and time-dependent manner. ...Furthermore, widdrol inhib …
Widdrol induces cell cycle arrest, associated with MCM down-regulation, in human colon adenocarcinoma cells.
Kwon HJ, Hong YK, Park C, Choi YH, Yun HJ, Lee EW, Kim BW. Kwon HJ, et al. Cancer Lett. 2010 Apr 1;290(1):96-103. doi: 10.1016/j.canlet.2009.09.003. Epub 2009 Oct 13. Cancer Lett. 2010. PMID: 19828235
Widdrol, an odorous compound extracted from Juniperus chinensis, has been shown to inhibit the in vitro growth of in human cancer cells. ...It was found that widdrol induces accumulation of sub-G1 phase and arrests in the G1 phase of the cell cycle. ...
Widdrol, an odorous compound extracted from Juniperus chinensis, has been shown to inhibit the in vitro growth of in human cancer cel …
Chemical Characterization of Trichoderma spp. Extracts with Antifungal Activity against Cocoa Pathogens.
Chóez-Guaranda I, Espinoza-Lozano F, Reyes-Araujo D, Romero C, Manzano P, Galarza L, Sosa D. Chóez-Guaranda I, et al. Molecules. 2023 Apr 4;28(7):3208. doi: 10.3390/molecules28073208. Molecules. 2023. PMID: 37049971 Free PMC article.
The inhibitory activity could be related to alkaloids, lactones, quinones, flavonoids, triterpenes, and sterols, as indicated by chemical screening and antifungal compounds, such as widdrol, beta-caryophyllene, tyrosol, butyl isobutyrate, sorbic acid, palmitic acid, palmit …
The inhibitory activity could be related to alkaloids, lactones, quinones, flavonoids, triterpenes, and sterols, as indicated by chemical sc …
Widdrol, a sesquiterpene isolated from Juniperus chinensis, inhibits angiogenesis by targeting vascular endothelial growth factor receptor 2 signaling.
Jin S, Yun HJ, Jeong HY, Oh YN, Park HJ, Yun SG, Kim BW, Kwon HJ. Jin S, et al. Oncol Rep. 2015 Sep;34(3):1178-84. doi: 10.3892/or.2015.4075. Epub 2015 Jun 24. Oncol Rep. 2015. PMID: 26133679
It was previously reported that widdrol has antitumor activity by apoptosis induction in cancer cells in vitro. ...Moreover, widdrol effectively reduced tumor growth and blood vessel formation in colon tumor xenograft mice. ...
It was previously reported that widdrol has antitumor activity by apoptosis induction in cancer cells in vitro. ...Moreover, widdr …
Anticholinesterase and β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitory Compounds from the Heartwood of Juniperus chinensis.
Jung HJ, Jung HA, Min BS, Choi JS. Jung HJ, et al. Chem Pharm Bull (Tokyo). 2015;63(11):955-60. doi: 10.1248/cpb.c15-00504. Chem Pharm Bull (Tokyo). 2015. PMID: 26521861 Free article.
Two new compounds (2, 3) and 20 known compounds (1, 4-22) were isolated from the heartwood of Juniperus chinensis LINNE (Cupressaceae), and their structures were elucidated as 9'-methoxycalocedrin (1); alpha-methyl artoflavanocoumarin (2); 5,7,4'-trihydroxy-2-styrylchromone (3); …
Two new compounds (2, 3) and 20 known compounds (1, 4-22) were isolated from the heartwood of Juniperus chinensis LINNE (Cupressaceae), and …
Sesquiterpenes from the wood of Juniperus lucayana.
Nuñez YO, Salabarria IS, Collado IG, Hernández-Galán R. Nuñez YO, et al. Phytochemistry. 2007 Oct;68(19):2409-14. doi: 10.1016/j.phytochem.2007.05.030. Epub 2007 Jul 2. Phytochemistry. 2007. PMID: 17606274
The major compounds isolated were evaluated for their antifungal activity against Botrytis cinerea. Widdrol (7) was the most active, reaching the 71% inhibition level on mycelial growth after 6 days....
The major compounds isolated were evaluated for their antifungal activity against Botrytis cinerea. Widdrol (7) was the most active, …
Exploration of fundamental and synthetic aspects of the intramolecular 4 + 3 cycloaddition reaction.
Harmata M. Harmata M. Acc Chem Res. 2001 Jul;34(7):595-605. doi: 10.1021/ar000064e. Acc Chem Res. 2001. PMID: 11456477 Review.
The evolution of the work has involved pursuing other methods for allylic cation generation, an investigation of stereochemical variables and applications, including the total syntheses of aphanamol I, widdrol, and (+)-dactylol....
The evolution of the work has involved pursuing other methods for allylic cation generation, an investigation of stereochemical variables an …
17 results