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Table representation of search results timeline featuring number of search results per year.

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1954 1
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1967 2
1968 2
1969 2
1971 1
1972 2
1973 2
1974 7
1975 7
1976 10
1977 30
1978 40
1979 36
1980 16
1981 22
1982 16
1983 14
1984 21
1985 18
1986 11
1987 8
1988 7
1989 10
1990 8
1991 2
1992 4
1993 6
1994 4
1995 1
1996 8
1997 4
1998 2
1999 3
2000 6
2001 2
2002 1
2003 4
2004 2
2005 6
2006 2
2007 4
2008 5
2009 3
2010 7
2011 5
2012 6
2013 8
2014 3
2015 8
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2023 27
2024 8

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501 results

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Page 1
Vincamine, from an antioxidant and a cerebral vasodilator to its anticancer potential.
Ren Y, DeRose K, Li L, Gallucci JC, Yu J, Douglas Kinghorn A. Ren Y, et al. Bioorg Med Chem. 2023 Sep 7;92:117439. doi: 10.1016/j.bmc.2023.117439. Epub 2023 Aug 9. Bioorg Med Chem. 2023. PMID: 37579526 Review.
Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been used clinically for the prevention and treatment of cerebrovascular disorders and insufficiencies. It has been well documented that antioxidants may contribute to cancer treatment, …
Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been used clinically for the prevention and t …
Vincamine as an agonist of G-protein-coupled receptor 40 effectively ameliorates diabetic peripheral neuropathy in mice.
Xu JW, Xu X, Ling Y, Wang YC, Huang YJ, Yang JZ, Wang JY, Shen X. Xu JW, et al. Acta Pharmacol Sin. 2023 Dec;44(12):2388-2403. doi: 10.1038/s41401-023-01135-1. Epub 2023 Aug 14. Acta Pharmacol Sin. 2023. PMID: 37580494
G-protein-coupled receptor 40 (GPR40) is predominantly expressed in pancreatic beta-cells, but also in spinal dorsal horn and dorsal root ganglion (DRG) neurons, regulating neuropathic pain. We previously have reported that vincamine (Vin), a monoterpenoid indole alkaloid …
G-protein-coupled receptor 40 (GPR40) is predominantly expressed in pancreatic beta-cells, but also in spinal dorsal horn and dorsal root ga …
Evaluation of vincamine against Acetylcholinesterase enzyme.
Syed Sayeed Ahmad, Khatoon A, Sajid Khan M, Khalid M, Alharbi AM, Siddiqui MH. Syed Sayeed Ahmad, et al. Cell Mol Biol (Noisy-le-grand). 2022 Jul 31;68(7):14-21. doi: 10.14715/cmb/2022.68.7.3. Cell Mol Biol (Noisy-le-grand). 2022. PMID: 36495525
Computationally, it confirmed the interaction between vincamine and AChE at an indistinguishable locus from that of substrate AChI (-3.94 kcal/mol) but with much higher binding energy. ...Thus, the present computational and enzyme kinetics studies conclude that vincamin …
Computationally, it confirmed the interaction between vincamine and AChE at an indistinguishable locus from that of substrate AChI (- …
Vincamine Ameliorates Epithelial-Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis in Rats; Targeting TGF-beta/MAPK/Snai1 Pathway.
Alaaeldin R, Mohyeldin RH, Bekhit AA, Gomaa W, Zhao QL, Fathy M. Alaaeldin R, et al. Molecules. 2023 Jun 9;28(12):4665. doi: 10.3390/molecules28124665. Molecules. 2023. PMID: 37375218 Free PMC article.
SOD and GPX were also increased following vincamine treatment, while MDA levels were decreased. Additionally, vincamine suppressed the expression of p53, Bax, TWIST, Snail, and Slug genes as well as the expression of factors such as TGF-beta1, p/t p38 MAPK, p/t ERK1 …
SOD and GPX were also increased following vincamine treatment, while MDA levels were decreased. Additionally, vincamine suppre …
Stereoselective Total Syntheses of C18-Oxo Eburnamine-Vincamine Alkaloids.
Zhang W, Wang Z, Lin G, Xue Y, Wu M, Tang P, Chen F. Zhang W, et al. Org Lett. 2022 Apr 1;24(12):2409-2413. doi: 10.1021/acs.orglett.2c00661. Epub 2022 Mar 21. Org Lett. 2022. PMID: 35312322
Here, we disclose the divergent total syntheses of representative C18-oxo eburnamine-vincamine alkaloids (+)-eburnaminol, (-)-larutenine, and (-)-cuanzine. ...
Here, we disclose the divergent total syntheses of representative C18-oxo eburnamine-vincamine alkaloids (+)-eburnaminol, (-)-laruten …
Vincamine, an active constituent of Vinca rosea ameliorates experimentally induced acute lung injury in Swiss albino mice through modulation of Nrf-2/NF-kappaB signaling cascade.
Patangrao Renushe A, Kumar Banothu A, Kumar Bharani K, Mekala L, Mahesh Kumar J, Neeradi D, Durga Veera Hanuman D, Gadige A, Khurana A. Patangrao Renushe A, et al. Int Immunopharmacol. 2022 Jul;108:108773. doi: 10.1016/j.intimp.2022.108773. Epub 2022 Apr 20. Int Immunopharmacol. 2022. PMID: 35453074
It was observed that vincamine at the dose of 40 mg/kg, significantly reduced LPS induced inflammatory cell count in blood and in bronchoalveolar lavage (BAL) fluid. ...Interestingly, histological changes were reversed in vincamine treated groups in a dose-dependent …
It was observed that vincamine at the dose of 40 mg/kg, significantly reduced LPS induced inflammatory cell count in blood and in bro …
The families of cognition enhancers.
Fröstl W, Maître L. Fröstl W, et al. Pharmacopsychiatry. 1989 Oct;22 Suppl 2:54-100. doi: 10.1055/s-2007-1014626. Pharmacopsychiatry. 1989. PMID: 2690152 Review.
Particular emphasis has been given to the following families: Piracetam-type, Co-dergocrine-type and vincamine-type compounds; cholinergic agents, psychostimulants, vasodilators, antianoxic agents, peptides, growth factors and gangliosides. ...
Particular emphasis has been given to the following families: Piracetam-type, Co-dergocrine-type and vincamine-type compounds; cholin …
Pharmacokinetics and metabolism of vincamine and related compounds.
Vereczkey L. Vereczkey L. Eur J Drug Metab Pharmacokinet. 1985 Apr-Jun;10(2):89-103. doi: 10.1007/BF03189702. Eur J Drug Metab Pharmacokinet. 1985. PMID: 3899662 Review.
The pharmacokinetics and metabolism of vincamine, vinpocetine, methylene-methoxy-apovincaminic acid ester and eburnamine have been reviewed. ...Vincamine and its derivatives show significant differences in metabolic pathway and their elimination is rapid in the spec …
The pharmacokinetics and metabolism of vincamine, vinpocetine, methylene-methoxy-apovincaminic acid ester and eburnamine have been re …
Therapeutic approaches for memory impairments.
Hock FJ. Hock FJ. Behav Brain Res. 1995 Jan 23;66(1-2):143-50. doi: 10.1016/0166-4328(94)00135-3. Behav Brain Res. 1995. PMID: 7755885 Review.
In the paper there were included and described in detail the following classes: piracetam-type compounds, co-dergocrine-type compounds, vasodilators and haemorheological agents, cholinesterase inhibitors, ACTH and vasopressin analogs and angiotensin II and angiotensin converting …
In the paper there were included and described in detail the following classes: piracetam-type compounds, co-dergocrine-type compounds, vaso …
Eburnamine derivatives and the brain.
Vas A, Gulyás B. Vas A, et al. Med Res Rev. 2005 Nov;25(6):737-57. doi: 10.1002/med.20043. Med Res Rev. 2005. PMID: 16158388 Review.
The Apocynaceae plant family contains a great number of so called eburnamine-vincamine alkaloids. Quite a few of these alkaloids exert varied pharmacological activities on the cell multiplication, cardiovascular system, and brain functions. ...We concentrate on the eburnam …
The Apocynaceae plant family contains a great number of so called eburnamine-vincamine alkaloids. Quite a few of these alkaloids exer …
501 results