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1985 3
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Evaluation of timefurone, a new anti-atherosclerotic drug, for its effects on lipoprotein cholesterol in male cynomolgus monkeys fed an atherogenic diet for 18 months.
Stevens TJ, Vidmar TJ, Day CE. Stevens TJ, et al. Atherosclerosis. 1985 Sep;56(3):301-11. doi: 10.1016/0021-9150(85)90005-x. Atherosclerosis. 1985. PMID: 3863622
Low density lipoprotein cholesterol [LDL-C] was significantly reduced 24-45% at all time periods and total-C was lowered 17-23% at weeks 12, 16, and 24-40 in the timefurone group. Very low density lipoprotein cholesterol [VLDL-C] was increased 68-156% from weeks 40-78 and …
Low density lipoprotein cholesterol [LDL-C] was significantly reduced 24-45% at all time periods and total-C was lowered 17-23% at weeks 12, …
Evaluation of timefurone, a new anti-atherosclerotic drug, for its effects on lipoprotein cholesterol in male SEA Japanese quail and rats.
Stevens TJ, Schurr PE, Gammill RB, Day CE. Stevens TJ, et al. Atherosclerosis. 1985 Sep;56(3):313-21. doi: 10.1016/0021-9150(85)90006-1. Atherosclerosis. 1985. PMID: 3863623
Timefurone was evaluated in several animal models for cholesterol-lowering and anti-atherosclerotic activity. ...High density lipoprotein cholesterol (HDL-C) was lowered 24% by the high timefurone dose. Timefurone (10, 20, 50 and 100 mg/kg/day in the diet) wa …
Timefurone was evaluated in several animal models for cholesterol-lowering and anti-atherosclerotic activity. ...High density lipopro …
[The effect of khellin and timefurone on secretion and catabolism of lipoproteins by cultured human and rabbit hepatocytes].
Volgushev SA, Kosykh VA, Podrez EA, Novikov DK, Fuki IV, Karpov RS, Repin VS. Volgushev SA, et al. Biokhimiia. 1990 Feb;55(2):346-51. Biokhimiia. 1990. PMID: 2340318 Russian.
Using human and rabbit hepatocyte cultures, the effects of khellin and timefurone on lipoprotein metabolism were studied with special reference to the following parameters: i) binding and degradation of 125I-labeled low density lipoproteins (LDL); ii) apoprotein B (apo-B) …
Using human and rabbit hepatocyte cultures, the effects of khellin and timefurone on lipoprotein metabolism were studied with special …
Comparative effects of khellin and timefurone on serum parameters in normal male cynomolgus monkeys.
Stevens TJ, Phillips WA, Day CE. Stevens TJ, et al. J Med Primatol. 1985;14(5):255-62. J Med Primatol. 1985. PMID: 4057238
Khellin-induced changes were significantly greater than those induced by timefurone. Neither drug altered body weights or clinical chemistry parameters. Monkeys treated with khellin, however, exhibited elevated levels of very low density lipoprotein cholesterol and marked …
Khellin-induced changes were significantly greater than those induced by timefurone. Neither drug altered body weights or clinical ch …