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Solid-Phase Synthesis of a Monofunctional trans-a(2)Pt(II) Complex Tethered to a Single-Stranded Oligonucleotide.
Schmidt KS, Filippov DV, Meeuwenoord NJ, van Der Marel GA, van Boom JH, Lippert B, Reedijk J. Schmidt KS, et al. Angew Chem Int Ed Engl. 2000 Jan;39(2):375-377. doi: 10.1002/(sici)1521-3773(20000117)39:2<375::aid-anie375>3.3.co;2-d. Angew Chem Int Ed Engl. 2000. PMID: 10649415
It was synthesized by a novel solid-phase approach comprising conjugation of immobilized tetrathymidylic acid with a trans-a(2)Pt(II) building unit, ammonolysis, and transformation of the resulting complex (R=1-N-cyclohexylmethylthyminate) into the chloro derivative …
It was synthesized by a novel solid-phase approach comprising conjugation of immobilized tetrathymidylic acid with a trans-a(2 …