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Quantitation of terameprocol in human plasma by liquid chromatography-tandem mass spectrometry.
Anders NM, Romo CG, Hemingway A, Ahluwalia MS, Rudek MA. Anders NM, et al. J Pharm Biomed Anal. 2022 Feb 5;209:114525. doi: 10.1016/j.jpba.2021.114525. Epub 2021 Dec 7. J Pharm Biomed Anal. 2022. PMID: 34906921 Free PMC article.
The global transcription inhibitor terameprocol is being evaluated clinically as an oral formulation to treat high-grade glioma. A sensitive, reliable method was developed to quantitate terameprocol using LC-MS/MS to perform detailed pharmacokinetic studies. ...
The global transcription inhibitor terameprocol is being evaluated clinically as an oral formulation to treat high-grade glioma. A se …
Terameprocol, a novel site-specific transcription inhibitor with anticancer activity.
Smolewski P. Smolewski P. IDrugs. 2008 Mar;11(3):204-14. IDrugs. 2008. PMID: 18311658 Review.
With this mechanism of action, terameprocol potentially inhibits the cell cycle, triggers apoptosis and decreases angiogenesis. Several preclinical studies have demonstrated the potent anticancer activity of terameprocol in tumor cell lines and animal models. In add …
With this mechanism of action, terameprocol potentially inhibits the cell cycle, triggers apoptosis and decreases angiogenesis. Sever …
Terameprocol (tetra-O-methyl nordihydroguaiaretic acid), an inhibitor of Sp1-mediated survivin transcription, induces radiosensitization in non-small cell lung carcinoma.
Sun Y, Giacalone NJ, Lu B. Sun Y, et al. J Thorac Oncol. 2011 Jan;6(1):8-14. doi: 10.1097/JTO.0b013e3181fa646a. J Thorac Oncol. 2011. PMID: 21107289 Free PMC article.
We also examined the combined effects of radiation and terameprocol on apoptosis and radiosensitivity. RESULTS: Using immunoblot analysis and luciferase assays, we confirmed that terameprocol decreases survivin transcription and protein expression. ...Additionally, …
We also examined the combined effects of radiation and terameprocol on apoptosis and radiosensitivity. RESULTS: Using immunoblot anal …
Phase I study of terameprocol in patients with recurrent high-grade glioma.
Grossman SA, Ye X, Peereboom D, Rosenfeld MR, Mikkelsen T, Supko JG, Desideri S; Adult Brain Tumor Consortium. Grossman SA, et al. Neuro Oncol. 2012 Apr;14(4):511-7. doi: 10.1093/neuonc/nor230. Epub 2012 Feb 8. Neuro Oncol. 2012. PMID: 22323663 Free PMC article. Clinical Trial.
Terameprocol is a global transcription inhibitor that affects cell division apoptosis, drug resistance, hypoxia responsive genes, and radiation resistance in hypoxia. ...Doses of 750, 1100, 1700, and 2200 mg/day were administered. Terameprocol was reformulated to av
Terameprocol is a global transcription inhibitor that affects cell division apoptosis, drug resistance, hypoxia responsive genes, and
Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines.
Eads D, Hansen R, Oyegunwa A, Cecil C, Culver C, Scholle F, Petty I, Laster S. Eads D, et al. J Inflamm (Lond). 2009 Jan 8;6:2. doi: 10.1186/1476-9255-6-2. J Inflamm (Lond). 2009. PMID: 19133137 Free PMC article.
The beneficial activity of this plant has been linked to the compound nordihydroguaiaretic acid (NDGA) and its various substituted derivatives. Recently, tetra-O-methyl NDGA or terameprocol (TMP) has been shown to inhibit the growth of certain tumor-derived cell lines and …
The beneficial activity of this plant has been linked to the compound nordihydroguaiaretic acid (NDGA) and its various substituted derivativ …
Phase I/II clinical safety studies of terameprocol vaginal ointment.
Khanna N, Dalby R, Tan M, Arnold S, Stern J, Frazer N. Khanna N, et al. Gynecol Oncol. 2007 Dec;107(3):554-62. doi: 10.1016/j.ygyno.2007.08.074. Epub 2007 Oct 1. Gynecol Oncol. 2007. PMID: 17905420 Clinical Trial.
There were no serious adverse events (SAEs) and possible treatment-related Adverse Events (AEs) reported were mild and self-limiting. There was no detectable absorption of terameprocol from the vaginal ointment application. CONCLUSIONS: Terameprocol in 1% and 2% vag …
There were no serious adverse events (SAEs) and possible treatment-related Adverse Events (AEs) reported were mild and self-limiting. There …
HMGB1 down-regulation mediates terameprocol vascular anti-proliferative effect in experimental pulmonary hypertension.
Nogueira-Ferreira R, Ferreira-Pinto MJ, Silva AF, Vitorino R, Justino J, Costa R, Moreira-Gonçalves D, Quignard JF, Ducret T, Savineau JP, Leite-Moreira AF, Ferreira R, Henriques-Coelho T. Nogueira-Ferreira R, et al. J Cell Physiol. 2017 Nov;232(11):3128-3138. doi: 10.1002/jcp.25763. Epub 2017 Mar 9. J Cell Physiol. 2017. PMID: 28036116
In the present study, we evaluated the potential therapeutic role of terameprocol (TMP), an inhibitor of cellular proliferation and promoter of apoptosis, in a well-established pre-clinical model of PAH induced by monocrotaline (MCT) and studied the biological pathways mod …
In the present study, we evaluated the potential therapeutic role of terameprocol (TMP), an inhibitor of cellular proliferation and p …
The anticancer activity of the transcription inhibitor terameprocol (meso-tetra-O-methyl nordihydroguaiaretic acid) formulated for systemic administration.
Lopez RA, Goodman AB, Rhodes M, Blomberg JA, Heller J. Lopez RA, et al. Anticancer Drugs. 2007 Sep;18(8):933-9. doi: 10.1097/CAD.0b013e32813148e0. Anticancer Drugs. 2007. PMID: 17667599
Terameprocol (50 and 100 mg/kg), paclitaxel (5 mg/kg), terameprocol and paclitaxel or vehicle was administered intraperitoneally daily for 21 days. ...Terameprocol alone reduced the rate of tumor growth, and a combination of terameprocol/paclitaxel red
Terameprocol (50 and 100 mg/kg), paclitaxel (5 mg/kg), terameprocol and paclitaxel or vehicle was administered intraperitoneal
Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid.
Pollara JJ, Laster SM, Petty IT. Pollara JJ, et al. Antiviral Res. 2010 Dec;88(3):287-95. doi: 10.1016/j.antiviral.2010.09.017. Epub 2010 Oct 1. Antiviral Res. 2010. PMID: 20888364
Terameprocol (TMP) is a methylated derivative of nordihydroguaiaretic acid, a phenolic antioxidant originally derived from creosote bush extracts. ...
Terameprocol (TMP) is a methylated derivative of nordihydroguaiaretic acid, a phenolic antioxidant originally derived from creosote b
Phase I study of the novel Cdc2/CDK1 and AKT inhibitor terameprocol in patients with advanced leukemias.
Tibes R, McDonagh KT, Lekakis L, Bogenberger JM, Kim S, Frazer N, Mohrland S, Bassett D, Garcia R, Schroeder K, Shanmugam V, Carpten J, Hagelstrom RT, Beaudry C, Von Hoff D, Shea TC. Tibes R, et al. Invest New Drugs. 2015 Apr;33(2):389-96. doi: 10.1007/s10637-014-0198-y. Epub 2014 Dec 19. Invest New Drugs. 2015. PMID: 25523151 Clinical Trial.
PURPOSE: Inhibiting survivin and Cdc2 (CDK1) has preclinical anti-leukemic activity. Terameprocol is a small molecule survivin and Cdc2/CDK1 inhibitor that was studied in a Phase I dose-escalation trial. PATIENTS AND METHODS: Sixteen patients with advanced acute myeloid le …
PURPOSE: Inhibiting survivin and Cdc2 (CDK1) has preclinical anti-leukemic activity. Terameprocol is a small molecule survivin and Cd …
44 results