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Synthesis and in vivo antitumor activity of 2-amino-9H-purine-6-sulfenamide, -sulfinamide, and -sulfonamide and related purine ribonucleosides.
Revankar GR, Hanna NB, Imamura N, Lewis AF, Larson SB, Finch RA, Avery TL, Robins RK. Revankar GR, et al. J Med Chem. 1990 Jan;33(1):121-8. doi: 10.1021/jm00163a020. J Med Chem. 1990. PMID: 2296010
Sulfenosine (8b) at 22 mg/kg per day X 1 showed a T/C of 170, whereas sulfinosine (9b) at 173 mg/kg per day X 1 showed a T/C of 167 against L1210 leukemia. The 5'-deoxy analogue of sulfinosine (9c) at 104 mg/kg per day also showed a T/C of 172. A single treatment wi …
Sulfenosine (8b) at 22 mg/kg per day X 1 showed a T/C of 170, whereas sulfinosine (9b) at 173 mg/kg per day X 1 showed a T/C of 167 a …
Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
Goel A, Aggarwal BB. Goel A, et al. Nutr Cancer. 2010;62(7):919-30. doi: 10.1080/01635581.2010.509835. Nutr Cancer. 2010. PMID: 20924967 Review.
Extensive research within the last decade in cell culture and in rodents has revealed that curcumin can sensitize tumors to different chemotherapeutic agents including doxorubicin, 5-FU, paclitaxel, vincristine, melphalan, butyrate, cisplatin, celecoxib, vinorelbine, gemcitabine, …
Extensive research within the last decade in cell culture and in rodents has revealed that curcumin can sensitize tumors to different chemot …
Synthesis and antitumor evaluation in mice of certain 7-deazapurine (pyrrolo[2,3-d]pyrimidine) and 3-deazapurine (imidazo[4,5-c]pyridine) nucleosides structurally related to sulfenosine, sulfinosine, and sulfonosine.
Ramasamy K, Imamura N, Hanna NB, Finch RA, Avery TL, Robins RK, Revankar GR. Ramasamy K, et al. J Med Chem. 1990 Apr;33(4):1220-5. doi: 10.1021/jm00166a021. J Med Chem. 1990. PMID: 2319564
7-Deaza (pyrrolo[2,3-d]pyrimidine) and 3-deaza (imidazo[4,5-c]pyridine) congeners of sulfenosine (5a and 9), sulfinosine (6a and 10), and sulfonosine (7a) have been prepared and evaluated for their antileukemic activity in mice. ...Even so, antileukemic activity appeared t …
7-Deaza (pyrrolo[2,3-d]pyrimidine) and 3-deaza (imidazo[4,5-c]pyridine) congeners of sulfenosine (5a and 9), sulfinosine (6a and 10), …
Sulfinosine-induced cell growth inhibition and apoptosis in human lung carcinomas in vitro.
Milosević J, Kanazir S, Medić-Mijacević L, Pejanović V, Stokić Z, Konjević G, Rakić L, Ruzdijić S. Milosević J, et al. Invest New Drugs. 2002 Aug;20(3):229-40. doi: 10.1023/a:1016281109100. Invest New Drugs. 2002. PMID: 12201486
Evidence of free nucleosomes and enzymatic labeling of fragmented DNA confirmed apoptosis involvement in sulfinosine cytotoxicity. In addition, flow-cytometric analysis showed that 25 microM sulfinosine arrested cell cycle progression at the G2M phase and induction …
Evidence of free nucleosomes and enzymatic labeling of fragmented DNA confirmed apoptosis involvement in sulfinosine cytotoxicity. In …
Purine nucleoside analog--sulfinosine modulates diverse mechanisms of cancer progression in multi-drug resistant cancer cell lines.
Dačević M, Isaković A, Podolski-Renić A, Isaković AM, Stanković T, Milošević Z, Rakić L, Ruždijić S, Pešić M. Dačević M, et al. PLoS One. 2013;8(1):e54044. doi: 10.1371/journal.pone.0054044. Epub 2013 Jan 11. PLoS One. 2013. PMID: 23326571 Free PMC article.
Identification of anti-cancer agents with the potential to kill cancer cells and at the same time inhibit MDR is important to intensify the search for novel therapeutic approaches. We examined the effects of sulfinosine (SF), a quite unexplored purine nucleoside analog, in …
Identification of anti-cancer agents with the potential to kill cancer cells and at the same time inhibit MDR is important to intensify the …
Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R).
Andjelkovic T, Pesic M, Bankovic J, Tanic N, Markovic ID, Ruzdijic S. Andjelkovic T, et al. Cancer Biol Ther. 2008 Jul;7(7):1024-32. doi: 10.4161/cbt.7.7.6036. Epub 2008 Apr 4. Cancer Biol Ther. 2008. PMID: 18414057
When sulfinosine was combined with a low dose of curcumin the drugs exerted a synergistic cytotoxic effect in NCI-H460/R cells. ...Sulfinosine and curcumin caused perturbations in cell cycle distribution in the NCI-H460/R cell line. ...
When sulfinosine was combined with a low dose of curcumin the drugs exerted a synergistic cytotoxic effect in NCI-H460/R cells. ... …
Chemotherapeutic characterization in mice of 2-amino-9-beta-D-ribofuranosylpurine-6-sulfinamide (sulfinosine), a novel purine nucleoside with unique antitumor properties.
Avery TL, Finch RA, Vasquez KM, Radparvar S, Hanna NB, Revankar GR, Robins RK. Avery TL, et al. Cancer Res. 1990 May 1;50(9):2625-30. Cancer Res. 1990. PMID: 2328488
Other findings of major interest to us were the different dosing characteristics of sulfinosine and 6TGR, the divergent efficiencies of the two drugs in generating cellular resistance, and the activity of sulfinosine against experimental leukemias refractory to 6TGR …
Other findings of major interest to us were the different dosing characteristics of sulfinosine and 6TGR, the divergent efficiencies …
Sulfinosine congeners: synthesis and antitumor activity in mice of certain N9-alkylpurines and purine ribonucleosides.
Hanna NB, Bhattacharya BK, Robins RK, Avery TL, Revankar GR. Hanna NB, et al. J Med Chem. 1994 Jan 7;37(1):177-83. doi: 10.1021/jm00027a022. J Med Chem. 1994. PMID: 8289192
A number of N9-alkyl-substituted purines and purine ribonucleosides have been synthesized as congeners of sulfinosine and evaluated for their antileukemic activity in mice. NaH-mediated alkylation of 6-chloropurine (4) and 2-amino-6-chloropurine (5) with certain alkyl brom …
A number of N9-alkyl-substituted purines and purine ribonucleosides have been synthesized as congeners of sulfinosine and evaluated f …
Sulfinosine enhances doxorubicin efficacy through synergism and by reversing multidrug resistance in the human non-small cell lung carcinoma cell line (NCI-H460/R).
Pesić M, Andjelković T, Banković J, Marković ID, Rakić L, Ruzdijić S. Pesić M, et al. Invest New Drugs. 2009 Apr;27(2):99-110. doi: 10.1007/s10637-008-9140-5. Epub 2008 May 21. Invest New Drugs. 2009. PMID: 18493718
A resistant non-small cell lung carcinoma cell line-NSCLC (NCI-H460/R) was established in order to investigate the potential of sulfinosine (SF) to overcome multidrug resistance (MDR). The cytotoxicity of doxorubicin (DOX) in NCI-H460/R cells was enhanced by interaction wi …
A resistant non-small cell lung carcinoma cell line-NSCLC (NCI-H460/R) was established in order to investigate the potential of sulfinosi …
Induced resistance in the human non small cell lung carcinoma (NCI-H460) cell line in vitro by anticancer drugs.
Pesic M, Markovic JZ, Jankovic D, Kanazir S, Markovic ID, Rakic L, Ruzdijic S. Pesic M, et al. J Chemother. 2006 Feb;18(1):66-73. doi: 10.1179/joc.2006.18.1.66. J Chemother. 2006. PMID: 16572896
Slight cross-resistance to two MDR-unrelated drugs 8-Cl-cAMP and sulfinosine was observed. Flow cytometry analysis showed that the accumulation of doxorubicin in the resistant cells was 88.4% lower than in the parental cells. ...
Slight cross-resistance to two MDR-unrelated drugs 8-Cl-cAMP and sulfinosine was observed. Flow cytometry analysis showed that the ac …
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