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Year Number of Results
1985 1
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1994 29
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Page 1
Streptavidin-Saporin: Converting Biotinylated Materials into Targeted Toxins.
Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA. Ancheta LR, et al. Toxins (Basel). 2023 Feb 27;15(3):181. doi: 10.3390/toxins15030181. Toxins (Basel). 2023. PMID: 36977072 Free PMC article. Review.
Streptavidin-Saporin can be considered a type of 'secondary' targeted toxin. The scientific community has taken advantage of this conjugate in clever and fruitful ways using many kinds of biotinylated targeting agents to send saporin into a cell selected for elimina …
Streptavidin-Saporin can be considered a type of 'secondary' targeted toxin. The scientific community has taken advantage of this con …
Saporin as a Commercial Reagent: Its Uses and Unexpected Impacts in the Biological Sciences-Tools from the Plant Kingdom.
Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA. Ancheta LR, et al. Toxins (Basel). 2022 Mar 2;14(3):184. doi: 10.3390/toxins14030184. Toxins (Basel). 2022. PMID: 35324681 Free PMC article. Review.
Development of commercial Saporin results in a technology termed 'molecular surgery', with Saporin as the scalpel. Its low toxicity (it has no efficient method of cell entry) and sturdy structure make Saporin a safe and simple molecule for many purposes. The …
Development of commercial Saporin results in a technology termed 'molecular surgery', with Saporin as the scalpel. Its low tox …
Saporin from Saponaria officinalis as a Tool for Experimental Research, Modeling, and Therapy in Neuroscience.
Bolshakov AP, Stepanichev MY, Dobryakova YV, Spivak YS, Markevich VA. Bolshakov AP, et al. Toxins (Basel). 2020 Aug 25;12(9):546. doi: 10.3390/toxins12090546. Toxins (Basel). 2020. PMID: 32854372 Free PMC article. Review.
Saporin, which is extracted from Saponaria officinalis, is a protein toxin that inactivates ribosomes. ...Limitations and future perspectives of use of saporin-based toxins in neuroscience are discussed....
Saporin, which is extracted from Saponaria officinalis, is a protein toxin that inactivates ribosomes. ...Limitations and future pers …
Saporin-S6: a useful tool in cancer therapy.
Polito L, Bortolotti M, Mercatelli D, Battelli MG, Bolognesi A. Polito L, et al. Toxins (Basel). 2013 Oct 7;5(10):1698-722. doi: 10.3390/toxins5101698. Toxins (Basel). 2013. PMID: 24105401 Free PMC article. Review.
Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponaria officinalis L. seeds. ...Moreover, saporin-S6 triggers multiple cell death pathways, rendering impossible the selection of RIP-resi …
Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponari …
Saporin immunotoxins.
Flavell DJ. Flavell DJ. Curr Top Microbiol Immunol. 1998;234:57-61. doi: 10.1007/978-3-642-72153-3_4. Curr Top Microbiol Immunol. 1998. PMID: 9670612 Review. No abstract available.
Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins.
Giansanti F, Flavell DJ, Angelucci F, Fabbrini MS, Ippoliti R. Giansanti F, et al. Toxins (Basel). 2018 Feb 13;10(2):82. doi: 10.3390/toxins10020082. Toxins (Basel). 2018. PMID: 29438358 Free PMC article. Review.
The high enzymatic activity, stability and resistance to conjugation procedures and especially the possibility to express recombinant fusions in yeast, make Saporin a well-suited tool for anti-cancer therapy approaches. Previous clinical work on RIPs-based Immunotoxins (in …
The high enzymatic activity, stability and resistance to conjugation procedures and especially the possibility to express recombinant fusion …
Perinatal 192 IgG-Saporin as Neuroteratogen.
Petrosini L, De Bartolo P, Cutuli D, Gelfo F. Petrosini L, et al. Curr Top Behav Neurosci. 2016;29:111-123. doi: 10.1007/7854_2015_418. Curr Top Behav Neurosci. 2016. PMID: 26695170 Review.
Perinatal immunotoxic lesions by 192 IgG-saporin induce long-lasting cholinergic depletion mimicking a number of developmental disorders reported in humans. The perinatal injection of 192 IgG-saporin induces several brain modifications, which are observed in neocort …
Perinatal immunotoxic lesions by 192 IgG-saporin induce long-lasting cholinergic depletion mimicking a number of developmental disord …
Saporin, a Polynucleotide-Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection.
Arslan I, Akgul H, Kara M. Arslan I, et al. SLAS Discov. 2021 Mar;26(3):330-335. doi: 10.1177/2472555220970911. Epub 2020 Nov 6. SLAS Discov. 2021. PMID: 33155515 Free PMC article.
Saporin, a type I ribosome-inactivating protein from soapwort plant, is a potent protein synthesis inhibitor. ...Saporin's high enzymatic activity, high stability, and resistance to conjugation procedures make it a well-suited tool for immunotherapy approaches.In th …
Saporin, a type I ribosome-inactivating protein from soapwort plant, is a potent protein synthesis inhibitor. ...Saporin's hig …
Analysis of the Sequence Preference of Saporin by Deep Sequencing.
Hauf S, Rotrattanadumrong R, Yokobayashi Y. Hauf S, et al. ACS Chem Biol. 2022 Sep 16;17(9):2619-2630. doi: 10.1021/acschembio.2c00531. Epub 2022 Aug 15. ACS Chem Biol. 2022. PMID: 35969718 Free PMC article.
Here, we combine the conventional aniline cleavage assay for depurinated nucleic acids with high-throughput sequencing to study sequence-specific depurination of oligonucleotides caused by saporin. Our data reveal the sequence preference of saporin for different sub …
Here, we combine the conventional aniline cleavage assay for depurinated nucleic acids with high-throughput sequencing to study sequence-spe …
The anti-tumoral potential of the saporin-based uPAR-targeting chimera ATF-SAP.
Zuppone S, Assalini C, Minici C, Bertagnoli S, Branduardi P, Degano M, Fabbrini MS, Montorsi F, Salonia A, Vago R. Zuppone S, et al. Sci Rep. 2020 Feb 13;10(1):2521. doi: 10.1038/s41598-020-59313-8. Sci Rep. 2020. PMID: 32054892 Free PMC article.
We investigated the anti-tumor potential of a chimeric recombinant fusion protein formed by the Ribosome Inactivating Protein saporin (SAP) and the amino-terminal fragment (ATF) of the urokinase-type plasminogen activator (uPA), whose receptor has been shown to be over-exp …
We investigated the anti-tumor potential of a chimeric recombinant fusion protein formed by the Ribosome Inactivating Protein saporin …
1,559 results