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1981 1
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Page 1
RU-26988--a new tool for the study of the mineralocorticoid receptor.
Gomez-Sanchez CE, Gomez-Sanchez EP. Gomez-Sanchez CE, et al. Endocrinology. 1983 Sep;113(3):1004-9. doi: 10.1210/endo-113-3-1004. Endocrinology. 1983. PMID: 6307658
RU-26988 competes with [3H]aldosterone and [3H]2 alpha-methyl-9 alpha-fluorocortisol, a powerful mineralocorticoid, for the cytosol receptor from renal slices of adrenalectomized rats with a relative potency of less than 0.5% in comparison to unlabeled aldosterone a …
RU-26988 competes with [3H]aldosterone and [3H]2 alpha-methyl-9 alpha-fluorocortisol, a powerful mineralocorticoid, for the cy …
Relative binding affinity of steroids for the corticosterone receptor system in rat hippocampus.
De Kloet ER, Veldhuis HD, Wagenaars JL, Bergink EW. De Kloet ER, et al. J Steroid Biochem. 1984 Aug;21(2):173-8. doi: 10.1016/0022-4731(84)90380-7. J Steroid Biochem. 1984. PMID: 6482428
Corticosterone also shows highest affinity to plasma transcortin and thymus cytosol in the presence of RU 26988. However, the rank-order in affinity by the competing steroids was distinctly different from that observed in the hippocampus; cf. aldosterone and dexamet …
Corticosterone also shows highest affinity to plasma transcortin and thymus cytosol in the presence of RU 26988. However, the …
Glucocorticoid activity of 11 beta,17 beta-dihydroxy-21-methyl-17 alpha-pregna-1,4,6-trien-20-yn-3-one (RU-26988).
Gomez-Sanchez EP, Gomez-Sanchez CE, Ferris MW. Gomez-Sanchez EP, et al. J Steroid Biochem. 1983 Dec;19(6):1819-22. doi: 10.1016/0022-4731(83)90366-7. J Steroid Biochem. 1983. PMID: 6142979
RU-26988 had 20% and dexamethasone 14% of the competing ability of triamcinolone acetonide for [3H] triamcinolone acetonide binding to the L-929 fibroblast receptor system. ...These data supplement other reports that RU-26988 might be a promising gluco …
RU-26988 had 20% and dexamethasone 14% of the competing ability of triamcinolone acetonide for [3H] triamcinolone acetonide bi …
Progesterone and synthetic steroids produce insulin resistance at the post-receptor level in adipocytes of female rats.
Sutter-Dub MT, Kaaya A, Sfaxi Al, Sodoyez-Goffaux F, Sodoyez JC, Sutter BC. Sutter-Dub MT, et al. Steroids. 1988 Nov-Dec;52(5-6):583-608. doi: 10.1016/0039-128x(88)90125-0. Steroids. 1988. PMID: 3076030
The effects of progesterone, its agonists (progestin RU-5020, glucocorticoid RU-26988) and antagonist (antiprogesterone, anti-glucocorticoid RU-486) were tested on isolated fat cells in vitro. ...Insulin-stimulated glucose oxidation was inhibited by progesterone, it …
The effects of progesterone, its agonists (progestin RU-5020, glucocorticoid RU-26988) and antagonist (antiprogesterone, anti- …
Receptor binding and biological activity of 18-hydroxycortisol.
Gomez-Sanchez EP, Gomez-Sanchez CE, Smith JS, Ferris MW, Foecking M. Gomez-Sanchez EP, et al. Endocrinology. 1984 Aug;115(2):462-6. doi: 10.1210/endo-115-2-462. Endocrinology. 1984. PMID: 6086271
The ability of 18-hydroxycortisol to compete with [3H]aldosterone for renal binding to the receptor was 0.13% that of unlabeled aldosterone. The addition of a specific glucocorticoid, RU-26988 (11 beta,17-dihydroxy-21-methyl-17 alpha-pregna-1,4,6-triene-20-yn-3-one) …
The ability of 18-hydroxycortisol to compete with [3H]aldosterone for renal binding to the receptor was 0.13% that of unlabeled aldosterone. …
Chemical differentiation of type I and type II receptors for adrenal steroids in brain cytosol.
Emadian SM, Luttge WG, Densmore CL. Emadian SM, et al. J Steroid Biochem. 1986 May;24(5):953-61. doi: 10.1016/0022-4731(86)90346-8. J Steroid Biochem. 1986. PMID: 2425155
Pretreating cytosol with dextran-coated charcoal (DCC) produced a 4.7-fold increase in the subsequent macromolecular binding of the mineralocorticoid, [3H]aldosterone (20 nM ALDO, in the presence of a 50-fold molar excess of the highly specific synthetic glucocorticoid, RU …
Pretreating cytosol with dextran-coated charcoal (DCC) produced a 4.7-fold increase in the subsequent macromolecular binding of the mineralo …
Identification of mineralocorticoid binding sites in rat brain by competition studies and density gradient centrifugation.
Coirini H, Marusic ET, De Nicola AF, Rainbow TC, McEwen BS. Coirini H, et al. Neuroendocrinology. 1983 Nov;37(5):354-60. doi: 10.1159/000123575. Neuroendocrinology. 1983. PMID: 6316188
A search for mineralocorticoid binding sites in neural tissue was carried out on the basis of competition by two mineralocorticoid antagonists (spironolactone and glycyrrhetinic acid), a mineralocorticoid agonist (9 alpha-fluorocortisol) and a pure glucocorticoid (RU 26 …
A search for mineralocorticoid binding sites in neural tissue was carried out on the basis of competition by two mineralocorticoid antagonis …
Aldosterone receptors.
Funder JW. Funder JW. Adv Exp Med Biol. 1986;196:145-52. doi: 10.1007/978-1-4684-5101-6_10. Adv Exp Med Biol. 1986. PMID: 2940820 Review. No abstract available.
Rat C6 glioma cells contain type I as well as type II corticosteroid receptors.
Beaumont K. Beaumont K. Brain Res. 1985 Sep 9;342(2):252-8. doi: 10.1016/0006-8993(85)91123-0. Brain Res. 1985. PMID: 4041825
The steroid specificity of glial cytosolic Type I receptors (deoxycorticosterone greater than corticosterone greater than aldosterone greater than dexamethasone greater than triamcinolone much greater than RU 26988) was identical to the steroid specificity of Type I …
The steroid specificity of glial cytosolic Type I receptors (deoxycorticosterone greater than corticosterone greater than aldosterone greate …
Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone.
Beaumont K, Fanestil DD. Beaumont K, et al. Endocrinology. 1983 Dec;113(6):2043-51. doi: 10.1210/endo-113-6-2043. Endocrinology. 1983. PMID: 6227474
After blockade of low affinity sites with a highly selective glucocorticoid (RU 26988), the order of steroids in competing for the high affinity receptor was desoxycorticosterone greater than fludrocortisone greater than corticosterone greater than aldosterone great …
After blockade of low affinity sites with a highly selective glucocorticoid (RU 26988), the order of steroids in competing for …
64 results