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The dopamine D2 agonists RU 24213 and RU 24926 are also kappa-opioid receptor antagonists.
Fortin M, Degryse M, Petit F, Hunt PF. Fortin M, et al. Neuropharmacology. 1991 Apr;30(4):409-12. doi: 10.1016/0028-3908(91)90068-m. Neuropharmacology. 1991. PMID: 1677169
The di-(phenethyl)-amine derivatives, RU 24213 and RU 24926 are widely used as selective dopamine D2-receptor agonists. ...With respect to the mu-receptor, RU 24926 shows low binding affinity and also an antagonist effect. ...
The di-(phenethyl)-amine derivatives, RU 24213 and RU 24926 are widely used as selective dopamine D2-receptor agonists. ...Wit …
Analgesic effect of the direct D2 dopamine receptor agonist RU 24926 and cross tolerance with morphine.
Suaudeau C, Costentin J. Suaudeau C, et al. Fundam Clin Pharmacol. 1995;9(2):147-52. doi: 10.1111/j.1472-8206.1995.tb00274.x. Fundam Clin Pharmacol. 1995. PMID: 7628827
The reversion of RU 24926-induced analgesia by naloxone was not accompanied by a reversion of hypothermia. Semi-chronic administration of RU 24926 (2.5 mg/kg, sc, 3 times a day for 3 days) completely desensitized to the analgesic effect induced by a 0. …
The reversion of RU 24926-induced analgesia by naloxone was not accompanied by a reversion of hypothermia. Semi-chronic admini …
Dopamine D2 synthesis-modulating receptors are present in the striatum of the guinea pig.
Johnson EA, Tsai CE, Lucci J, Harrison-Shahan Y, Azzaro AJ. Johnson EA, et al. Neuropharmacology. 1992 Jan;31(1):95-101. doi: 10.1016/0028-3908(92)90167-n. Neuropharmacology. 1992. PMID: 1347405
However, the catechol-containing agonists dopamine (EC50 = 44.7 microM) and SKF 38393 (EC50 = 35.5 microM) were more potent than the non-catechol agonist RU 24926 (EC50 = 447 microM). All of the agonists were much more potent in synaptosome-rich preparations of guin …
However, the catechol-containing agonists dopamine (EC50 = 44.7 microM) and SKF 38393 (EC50 = 35.5 microM) were more potent than the non-cat …
Stimulation of both D1 and D2 dopamine receptors appears necessary for full expression of postsynaptic effects of dopamine agonists: a neurophysiological study.
Carlson JH, Bergstrom DA, Walters JR. Carlson JH, et al. Brain Res. 1987 Jan 6;400(2):205-18. doi: 10.1016/0006-8993(87)90619-6. Brain Res. 1987. PMID: 2880637
The agonists studied were apomorphine and pergolide, which interact with both D1 and D2 receptors, and the selective D2 agonists quinpirole and RU 24926. Drugs were administered systemically. The 4 dopamine agonists were equipotent and equiefficacious at inhibiting …
The agonists studied were apomorphine and pergolide, which interact with both D1 and D2 receptors, and the selective D2 agonists quinpirole …
Inhibition of [3H]dopamine uptake by platelets by the dopamine-D2 receptor agonist RU 24926.
Dean B, Srikanthan P, Copolov DL. Dean B, et al. J Pharm Pharmacol. 1991 Jan;43(1):56-7. doi: 10.1111/j.2042-7158.1991.tb05451.x. J Pharm Pharmacol. 1991. PMID: 1676063
We have examined the effect of the dopamine-D2 receptor agonist RU 24926 (N-n-propyl-di-beta(3-hydroxy-phenyl)-ethylamine HCl) on [3H]dopamine uptake by human platelets. ...These data suggest that RU 24926 reduces [3H]dopamine uptake by platelets by co …
We have examined the effect of the dopamine-D2 receptor agonist RU 24926 (N-n-propyl-di-beta(3-hydroxy-phenyl)-ethylamine HCl) …
An automated method for the assessment of spontaneous and stereotyped climbing behavior in mice. Effects of the selective D1- and D2-dopamine receptor agonists SKF-38393 and RU-24926 and their association.
Simon P, Charpentier S, Costentin J. Simon P, et al. Methods Find Exp Clin Pharmacol. 1991 Mar;13(2):99-104. Methods Find Exp Clin Pharmacol. 1991. PMID: 1830125
In order to validate this method, in the present study the ability of apomorphine to induce climbing in mice, and the effects of the D1-dopamine receptor agonist SKF-38393 and the D2-dopamine agonist RU-24926 and their association were investigated....
In order to validate this method, in the present study the ability of apomorphine to induce climbing in mice, and the effects of the D1-dopa …
Electrophysiological, biochemical and behavioral assessment of dopamine autoreceptor activation by a series of dopamine agonists.
Yarbrough GG, McGuffin-Clineschmidt J, Singh DK, Haubrich DR, Bendesky RJ, Martin GE. Yarbrough GG, et al. Eur J Pharmacol. 1984 Mar 16;99(1):73-8. doi: 10.1016/0014-2999(84)90433-3. Eur J Pharmacol. 1984. PMID: 6723791
The compounds under investigation were apomorphine, N-n-propyl-norapomorphine, lergotrile, bromocriptine, RU 24926 and 6-ethyl-9-oxaergoline (EOE). There was a high degree of correlation between the rank order of potency of the compounds in all three of the presumpt …
The compounds under investigation were apomorphine, N-n-propyl-norapomorphine, lergotrile, bromocriptine, RU 24926 and 6-ethyl …
Mouse locomotor activity: an in vivo test for dopamine autoreceptor activation.
Martin GE, Bendesky RJ. Martin GE, et al. J Pharmacol Exp Ther. 1984 Jun;229(3):706-11. J Pharmacol Exp Ther. 1984. PMID: 6144790
These agents were: apomorphine, n-propylnorapomorphine, pergolide, RU 24213, RU 24926, (-)-6-ethyl-9-oxaergoline and lisuride. SKF 38393 failed to exert any significant effect on the LMA of the mouse. ...
These agents were: apomorphine, n-propylnorapomorphine, pergolide, RU 24213, RU 24926, (-)-6-ethyl-9-oxaergoline and lisuride. …
Dopamine autoreceptors and the effects of drugs on locomotion and dopamine synthesis.
Brown F, Campbell W, Mitchell PJ, Randall K. Brown F, et al. Br J Pharmacol. 1985 Apr;84(4):853-60. doi: 10.1111/j.1476-5381.1985.tb17379.x. Br J Pharmacol. 1985. PMID: 4005487 Free PMC article.
Idazoxan antagonized inhibition of locomotion due to alpha 2-agonists but not dopamine agonists. RU 24926 (N-propyl-N,N-di[2-(3-hydroxyphenyl)ethyl]amine) was antagonized by both spiperone and idazoxan. ...
Idazoxan antagonized inhibition of locomotion due to alpha 2-agonists but not dopamine agonists. RU 24926 (N-propyl-N,N-di[2-( …
Stimulation of D1 and D2 dopamine receptors produces additive anorectic effects.
Ladurelle N, Duterte-Boucher D, Costentin J. Ladurelle N, et al. Fundam Clin Pharmacol. 1991;5(6):481-90. doi: 10.1111/j.1472-8206.1991.tb00734.x. Fundam Clin Pharmacol. 1991. PMID: 1683341
This effect was reversed by the D1 antagonist SCH 23390. In similar conditions, the D2 dopamine agonist RU 24926 also induced dose dependent anorexia (ED50 = 0.19 mg/kg). ...The dose response curve obtained by associating SKF 38393 (2.5 mg/kg) with increasing doses …
This effect was reversed by the D1 antagonist SCH 23390. In similar conditions, the D2 dopamine agonist RU 24926 also induced …
45 results