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Adjuvant activities of quinonyl-N-acetyl muramyl dipeptides in mice and guinea pigs.
Saiki I, Tanio Y, Yamawaki M, Uemiya M, Kobayashi S, Fukuda T, Yukimasa H, Yamamura Y, Azuma I. Saiki I, et al. Infect Immun. 1981 Jan;31(1):114-21. doi: 10.1128/iai.31.1.114-121.1981. Infect Immun. 1981. PMID: 6971259 Free PMC article.
N-Acetyl muramyl-L-valyl-D-isoglutamine (MurNac-L-Val-D-isoGln), QS-10-MurNAc-L-Val-D-isoGln, and their methyl esters were shown to have potent adjuvant activity on the induction of delayed-type hypersensitivity to monoazobenzenarsonate-N-acetyl-L-tyrosine in guinea pigs and on t …
N-Acetyl muramyl-L-valyl-D-isoglutamine (MurNac-L-Val-D-isoGln), QS-10-MurNAc-L-Val-D-isoGln, and their methyl esters were shown to have pot …
Effect of quinonyl-N-acetyl muramyl dipeptide on immune responses in tumor-bearing mice.
Saiki I, Tanio Y, Yamamoto KI, Yamamura Y, Azuma I. Saiki I, et al. Infect Immun. 1983 Jan;39(1):137-41. doi: 10.1128/iai.39.1.137-141.1983. Infect Immun. 1983. PMID: 6822411 Free PMC article.
However, primary tumor size and the numbers of lung metastases were not affected when quinonyl-MDP-66 was administered under the present experimental conditions. Intraperitoneal injection of quinonyl-MDP-66 in mice with Lewis lung carcino …
However, primary tumor size and the numbers of lung metastases were not affected when quinonyl-MDP-66 was administered …
Activation of macrophages by quinonyl-N-acetylmuramyl dipeptide.
Saiki I, Tokushima Y, Nishimura K, Yamamura Y, Azuma I. Saiki I, et al. Infect Immun. 1983 May;40(2):622-8. doi: 10.1128/iai.40.2.622-628.1983. Infect Immun. 1983. PMID: 6840857 Free PMC article.
The effect of 6-O-QS-10-N-acetylmuramyl-L-valyl-D-isoglutamine methyl ester (quinonyl-MDP-66) on various functions of macrophages was examined. ...The fact that synthetic quinonyl-MDP-66 stimulates the macrophages to become more cytotoxic …
The effect of 6-O-QS-10-N-acetylmuramyl-L-valyl-D-isoglutamine methyl ester (quinonyl-MDP-66) on various functions of m …
Antitumor activity on line 10 hepatoma in strain 2 guinea pigs and pharmaceutical properties of quinonyl-MDP preparations.
Azuma I, Ogawa Y, Igari Y, Ukei S, Yamamura Y. Azuma I, et al. Methods Find Exp Clin Pharmacol. 1986 Jan;8(1):15-8. Methods Find Exp Clin Pharmacol. 1986. PMID: 3702541
The reconstituted suspension of quinonyl-MDP-66 in oil-in-water emulsion was stable for more than 24 hrs. The oil-in-water emulsion of quinonyl-MDP-66 as prepared above was effective for the distribution of quinonyl-MDP-6 …
The reconstituted suspension of quinonyl-MDP-66 in oil-in-water emulsion was stable for more than 24 hrs. The oil-in-wa …