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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1948 1
1949 1
1955 1
1956 1
1957 1
1959 3
1960 4
1962 4
1964 3
1965 6
1966 3
1968 3
1969 4
1970 2
1971 2
1972 5
1973 3
1974 8
1975 9
1976 15
1977 15
1978 21
1979 20
1980 30
1981 26
1982 33
1983 32
1984 30
1985 46
1986 47
1987 42
1988 49
1989 71
1990 86
1991 73
1992 93
1993 79
1994 96
1995 94
1996 97
1997 95
1998 85
1999 91
2000 102
2001 100
2002 89
2003 92
2004 95
2005 115
2006 95
2007 107
2008 112
2009 88
2010 105
2011 142
2012 134
2013 130
2014 139
2015 117
2016 112
2017 115
2018 113
2019 129
2020 153
2021 176
2022 144
2023 121
2024 60

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4,028 results

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Page 1
IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
Zheng K, Sha N, Hou G, Leng Z, Zhao Q, Zhang L, He L, Xu M, Jiang Y, Chen T. Zheng K, et al. Nat Commun. 2023 Sep 30;14(1):6117. doi: 10.1038/s41467-023-41658-z. Nat Commun. 2023. PMID: 37777542 Free PMC article.
The proline synthesis is importantly involved in tumor growth under hypoxia, while the underlying mechanism remains to be further investigated. Here we show that pyrroline-5-carpoxylate reductase-1 (PYCR1), displaying a constant nuclear localization, is phosphorylated by n …
The proline synthesis is importantly involved in tumor growth under hypoxia, while the underlying mechanism remains to be further investigat …
Metal-mediated synthesis of pyrrolines.
Medran NS, La-Venia A, Testero SA. Medran NS, et al. RSC Adv. 2019 Feb 27;9(12):6804-6844. doi: 10.1039/c8ra10247c. eCollection 2019 Feb 22. RSC Adv. 2019. PMID: 35518475 Free PMC article. Review.
Pyrrolines-the dihydro derivatives of pyrroles-have three structural isomer classes, depending on the location of the double bond: 1-pyrrolines (3,4-dihydro-2H-pyrroles), 2-pyrrolines (2,3-dihydro-1H-pyrroles) and 3-pyrrolines (2,5-dihydro-1H-pyrroles) …
Pyrrolines-the dihydro derivatives of pyrroles-have three structural isomer classes, depending on the location of the double bond: 1- …
Redox-neutral manganese-catalyzed synthesis of 1-pyrrolines.
Feng T, Liu C, Wu Z, Wu X, Zhu C. Feng T, et al. Chem Sci. 2022 Feb 9;13(9):2669-2673. doi: 10.1039/d2sc00015f. eCollection 2022 Mar 2. Chem Sci. 2022. PMID: 35340851 Free PMC article.
This report describes a manganese-catalyzed radical [3 + 2] cyclization of cyclopropanols and oxime ethers, leading to valuable multi-functional 1-pyrrolines. In this redox-neutral process, the oxime ethers function as internal oxidants and H-donors. ...This intermolecular …
This report describes a manganese-catalyzed radical [3 + 2] cyclization of cyclopropanols and oxime ethers, leading to valuable multi-functi …
Expression and kinetic characterization of PYCR3.
Meeks KR, Tanner JJ. Meeks KR, et al. Arch Biochem Biophys. 2023 Jan 1;733:109468. doi: 10.1016/j.abb.2022.109468. Epub 2022 Nov 19. Arch Biochem Biophys. 2023. PMID: 36414121 Free PMC article.
PYCRs are proline biosynthetic enzymes that catalyze the NAD(P)H-dependent reduction of delta(1)-pyrroline-5-carboxylate (P5C) to proline in humans. PYCRs - especially PYCR1 - are upregulated in many types of cancers and have been implicated in the altered metabolism of ca …
PYCRs are proline biosynthetic enzymes that catalyze the NAD(P)H-dependent reduction of delta(1)-pyrroline-5-carboxylate (P5C) to pro …
[Hyperprolinemia].
Matsumura R. Matsumura R. Ryoikibetsu Shokogun Shirizu. 2000;(29 Pt 4):389. Ryoikibetsu Shokogun Shirizu. 2000. PMID: 11031977 Review. Japanese. No abstract available.
Substrate channeling in proline metabolism.
Arentson BW, Sanyal N, Becker DF. Arentson BW, et al. Front Biosci (Landmark Ed). 2012 Jan 1;17(1):375-88. doi: 10.2741/3932. Front Biosci (Landmark Ed). 2012. PMID: 22201749 Free PMC article. Review.
Results from different groups have indicated that substrate channeling of proline metabolic intermediates may be a critical mechanism. One intermediate is pyrroline-5-carboxylate (P5C), which upon hydrolysis opens to glutamic semialdehyde (GSA). ...
Results from different groups have indicated that substrate channeling of proline metabolic intermediates may be a critical mechanism. One i …
Evaluation of 2-acetyl-1-pyrroline in foods, with an emphasis on rice flavour.
Wei X, Handoko DD, Pather L, Methven L, Elmore JS. Wei X, et al. Food Chem. 2017 Oct 1;232:531-544. doi: 10.1016/j.foodchem.2017.04.005. Epub 2017 Apr 5. Food Chem. 2017. PMID: 28490108 Free article. Review.
The popcorn-like aroma compound 2-acetyl-1-pyrroline (2-AP) is a key contributor to the desirable aroma of fragrant rice and is also important in the aroma of other foods, such as pandan leaf, popcorn and Mediterranean sausage. ...This review examines the formation of 2-AP …
The popcorn-like aroma compound 2-acetyl-1-pyrroline (2-AP) is a key contributor to the desirable aroma of fragrant rice and is also …
2-Butyl-2-tert-butyl-5,5-diethylpyrrolidine-1-oxyls: Synthesis and Properties.
Zhurko IF, Dobrynin S, Gorodetskii AA, Glazachev YI, Rybalova TV, Chernyak EI, Asanbaeva N, Bagryanskaya EG, Kirilyuk IA. Zhurko IF, et al. Molecules. 2020 Feb 14;25(4):845. doi: 10.3390/molecules25040845. Molecules. 2020. PMID: 32075085 Free PMC article.
Here, two highly strained nitroxides, 5-(tert-butyl)-5-butyl-2,2-diethyl-3-hydroxypyrrolidin-1-oxyl (4) and 2-(tert-butyl)-2-butyl-5,5-diethyl-3,4-bis(hydroxymethyl)pyrrolidin-1-oxyl (5), were prepared via a reaction of the corresponding 2-tert-butyl-1-pyrroline 1-oxides w …
Here, two highly strained nitroxides, 5-(tert-butyl)-5-butyl-2,2-diethyl-3-hydroxypyrrolidin-1-oxyl (4) and 2-(tert-butyl)-2-butyl-5,5-dieth …
Nickel-Catalyzed Enantioselective Synthesis of 2,3,4-Trisubstituted 3-Pyrrolines.
Tambe SD, Ka CH, Hwang HS, Bae J, Iqbal N, Cho EJ. Tambe SD, et al. Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202203494. doi: 10.1002/anie.202203494. Epub 2022 May 17. Angew Chem Int Ed Engl. 2022. PMID: 35506687
The development of synthetic methods to produce highly functionalized chiral 3-pyrrolines is of indisputable importance because of their prevalence in natural and synthetic bioactive molecules. Unfortunately, previous general cycloaddition approaches using allenoates, coul …
The development of synthetic methods to produce highly functionalized chiral 3-pyrrolines is of indisputable importance because of th …
4,028 results