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Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized-Induced Bone Loss by Suppressing Reactive Oxygen Species.
Chen K, Qiu P, Yuan Y, Zheng L, He J, Wang C, Guo Q, Kenny J, Liu Q, Zhao J, Chen J, Tickner J, Fan S, Lin X, Xu J. Chen K, et al. Theranostics. 2019 Feb 28;9(6):1634-1650. doi: 10.7150/thno.30206. eCollection 2019. Theranostics. 2019. PMID: 31037128 Free PMC article.
Rationale: Growing evidence indicates that intracellular reactive oxygen species (ROS) accumulation is a critical factor in the development of osteoporosis by triggering osteoclast formation and function. Pseurotin A (Pse) is a secondary metabolite isolated from Aspergillu …
Rationale: Growing evidence indicates that intracellular reactive oxygen species (ROS) accumulation is a critical factor in the development …
Pseurotin D inhibits delayed type IV hypersensitivity response.
Skoroplyas S, Vašíček O, Chorvátová M, Daďová P, Lehká K, Kubala L. Skoroplyas S, et al. Chem Biol Interact. 2022 Dec 1;368:110241. doi: 10.1016/j.cbi.2022.110241. Epub 2022 Oct 28. Chem Biol Interact. 2022. PMID: 36349590
However, the type of immune response affected by pseurotins and the mechanistic details underlying these effects are still not understood. Thus, the aim of the current study was to examine the effects of pseurotin D on delayed-type IV hypersensitivity (DTH) reaction …
However, the type of immune response affected by pseurotins and the mechanistic details underlying these effects are still not unders …
Regulation of pseurotin A biosynthesis by GliZ and zinc in Aspergillus fumigatus.
Seo H, Kang S, Lee D, Yun CW. Seo H, et al. Sci Rep. 2023 Feb 10;13(1):2431. doi: 10.1038/s41598-023-29753-z. Sci Rep. 2023. PMID: 36765124 Free PMC article.
Furthermore, upregulated expression of pseurotin A biosynthetic genes and higher production of pseurotin A were observed in the zafA deletion strain. Interestingly, the deletion of gliZ, a transcriptional activator of gliotoxin biosynthesis genes, resulted in upregu …
Furthermore, upregulated expression of pseurotin A biosynthetic genes and higher production of pseurotin A were observed in th …
Stereocontrolled Synthesis of Pseurotin A(2).
Jachak GR, Tharra PR, Sevelda P, Švenda J. Jachak GR, et al. J Org Chem. 2021 Sep 3;86(17):11845-11861. doi: 10.1021/acs.joc.1c01152. Epub 2021 Aug 11. J Org Chem. 2021. PMID: 34378926
We report synthesis of two diastereomeric structures previously proposed for the complex secondary metabolite pseurotin A(2). Both structures were accessed from the same building blocks taking advantage of a stereodivergent nickel(II)-diamine-catalyzed 1,4-addition of a ch …
We report synthesis of two diastereomeric structures previously proposed for the complex secondary metabolite pseurotin A(2). Both st …
Pseurotin D Inhibits the Activation of Human Lymphocytes.
Rubanova D, Dadova P, Vasicek O, Kubala L. Rubanova D, et al. Int J Mol Sci. 2021 Feb 16;22(4):1938. doi: 10.3390/ijms22041938. Int J Mol Sci. 2021. PMID: 33669259 Free PMC article.
PURPOSE: Complex characterization of the effects of pseurotin D on human lymphocyte activation in order to understand the potential of pseurotin to modulate immune response in humans. ...CONCLUSIONS: Our results advance the current mechanistic understanding of the …
PURPOSE: Complex characterization of the effects of pseurotin D on human lymphocyte activation in order to understand the potential o …
Pseurotin D Induces Apoptosis through Targeting Redox Sensitive Pathways in Human Lymphoid Leukemia Cells.
Mosejová E, Bosnjakovic R, Kubala L, Vašíček O. Mosejová E, et al. Antioxidants (Basel). 2021 Oct 5;10(10):1576. doi: 10.3390/antiox10101576. Antioxidants (Basel). 2021. PMID: 34679711 Free PMC article.
Our results showed that pseurotin D was able to significantly inhibit the proliferation of MEC-1 cells and arrested them in the G2/M cell cycle phase. ...Our results show the pseurotins family as promising compounds which could serve as a basis for the development o …
Our results showed that pseurotin D was able to significantly inhibit the proliferation of MEC-1 cells and arrested them in the G2/M …
Protective Effects of Prunasin A against the Differentiation of Osteoclasts and Destruction of Cartilage via the Receptor Activator of Nuclear Factor-Kappa-Β Ligand/Mitogen-Activated Protein Kinase/Osteoprotegerin Pathway in a Rat Model of Arthritis.
Chen T, Zhang B, Lin Y, Pan J, Zhao XX, Ren SX. Chen T, et al. Pharmacology. 2019;104(5-6):216-225. doi: 10.1159/000502537. Epub 2019 Sep 12. Pharmacology. 2019. PMID: 31514188 Retracted.
The present study evaluated the protective effects of pseurotin A against inflammation and the destruction of cartilage in a rat model of rheumatoid arthritis (RA). RA was induced by intradermal injections of Freund's complete adjuvant (1 mg/mL), and the treatment with …
The present study evaluated the protective effects of pseurotin A against inflammation and the destruction of cartilage in a rat mode …
Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii.
Schmeda-Hirschmann G, Hormazabal E, Rodriguez JA, Theoduloz C. Schmeda-Hirschmann G, et al. Z Naturforsch C J Biosci. 2008 May-Jun;63(5-6):383-8. doi: 10.1515/znc-2008-5-612. Z Naturforsch C J Biosci. 2008. PMID: 18669024 Free article.
Pseurotin A and cycloaspeptide A presented low cytotoxicity towards human lung fibroblasts with IC50 > or = 1000 microM. Pseurotin A showed a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 …
Pseurotin A and cycloaspeptide A presented low cytotoxicity towards human lung fibroblasts with IC50 > or = 1000 microM. Pseuro …
Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells.
Vašíček O, Fedr R, Skoroplyas S, Chalupa D, Sklenář M, Tharra PR, Švenda J, Kubala L. Vašíček O, et al. Phytomedicine. 2020 Apr;69:153194. doi: 10.1016/j.phymed.2020.153194. Epub 2020 Feb 22. Phytomedicine. 2020. PMID: 32146299
STUDY DESIGN: Effects of two natural pseurotins (pseurotins A and D) and a collection of fully synthetic pseurotin analogs were studied on mouse B-cells stimulated by the combination of IL-4 and E. coli lipopolysaccharide. ...RESULTS: We discovered that sever …
STUDY DESIGN: Effects of two natural pseurotins (pseurotins A and D) and a collection of fully synthetic pseurotin anal …
Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A(2) and Azaspirofuran A.
Copmans D, Rateb M, Tabudravu JN, Pérez-Bonilla M, Dirkx N, Vallorani R, Diaz C, Pérez Del Palacio J, Smith AJ, Ebel R, Reyes F, Jaspars M, de Witte PAM. Copmans D, et al. ACS Chem Neurosci. 2018 Jul 18;9(7):1652-1662. doi: 10.1021/acschemneuro.8b00060. Epub 2018 Apr 19. ACS Chem Neurosci. 2018. PMID: 29672015 Free article.
Within the framework of this project, seven known heterospirocyclic gamma-lactams, namely, pseurotin A, pseurotin A(2), pseurotin F1, 11- O-methylpseurotin A, pseurotin D, azaspirofuran A, and azaspirofuran B, were isolated from the bioactive marine fu …
Within the framework of this project, seven known heterospirocyclic gamma-lactams, namely, pseurotin A, pseurotin A(2), pse …
87 results