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Thalidomide teratogenesis: evidence for a toxic arene oxide metabolite.
Gordon GB, Spielberg SP, Blake DA, Balasubramanian V. Gordon GB, et al. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2545-8. doi: 10.1073/pnas.78.4.2545. Proc Natl Acad Sci U S A. 1981. PMID: 6941308 Free PMC article.
The metabolite thus appears to be in arene oxide, consistent with the previously reported isolation of phenolic metabolites of thalidomide from the urine of treated animals. Two teratogenic analogs of thalidomide (phthalimidophthalimide and phthalimidinoglutarimide) were a …
The metabolite thus appears to be in arene oxide, consistent with the previously reported isolation of phenolic metabolites of thalidomide f …
Thalidomide derivatives and the immune system. 6. Effects of two derivatives with no obvious teratogenic potency on the pattern of integrins and other surface receptors on blood cells of marmosets.
Nogueira AC, Neubert R, Felies A, Jacob-Müller U, Frankus E, Neubert D. Nogueira AC, et al. Life Sci. 1996;58(4):337-48. doi: 10.1016/0024-3205(95)02293-7. Life Sci. 1996. PMID: 8538370
The two thalidomide (Thd) derivatives beta-EM12 and phthalimidophthalimide (Phtpht), which exhibit no obvious teratogenicity, were tested for their ability to induce changes in the pattern of lymphocyte subpopulations, and especially changes in integrin receptors, in marmo …
The two thalidomide (Thd) derivatives beta-EM12 and phthalimidophthalimide (Phtpht), which exhibit no obvious teratogenicity, were te …
Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. 5. Lack of teratogenic effects of phthalimidophthalmide.
Klug S, Felies A, Stürje H, Nogueira AC, Neubert R, Frankus E. Klug S, et al. Arch Toxicol. 1994;68(3):203-5. doi: 10.1007/s002040050055. Arch Toxicol. 1994. PMID: 8024468
The teratogenic potency of the thalidomide (Thd) derivative phthalimidophthalimide (Phtpht) was assessed in the common marmoset (Callithrix jacchus), by oral administration of the relatively high daily dose of 50 mg Phtpht/kg body wt, during the susceptible period (days 48 …
The teratogenic potency of the thalidomide (Thd) derivative phthalimidophthalimide (Phtpht) was assessed in the common marmoset (Call …