Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1983 1
1984 1
1992 1
1993 1
1994 1
1995 1
1998 1
1999 1
2003 1
2004 1
2005 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

12 results

Results by year

Filters applied: . Clear all
Page 1
Protease-activated "prodrugs" for cancer chemotherapy.
Carl PL, Chakravarty PK, Katzenellenbogen JA, Weber MJ. Carl PL, et al. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2224-8. doi: 10.1073/pnas.77.4.2224. Proc Natl Acad Sci U S A. 1980. PMID: 6246527 Free PMC article.
To provide an initial test of this concept we have synthesized peptidyl prodrugs of the structure D-Val-Leu-Lys-X in which the peptidyl portion has been designed to allow the prodrug to serve as an excellent plasmin substrate and X is an anticancer drug-either the glutamine analo …
To provide an initial test of this concept we have synthesized peptidyl prodrugs of the structure D-Val-Leu-Lys-X in which the peptidyl port …
Efficient cancer therapy with a nanobody-based conjugate.
Cortez-Retamozo V, Backmann N, Senter PD, Wernery U, De Baetselier P, Muyldermans S, Revets H. Cortez-Retamozo V, et al. Cancer Res. 2004 Apr 15;64(8):2853-7. doi: 10.1158/0008-5472.can-03-3935. Cancer Res. 2004. PMID: 15087403
In vitro experiments showed that the nanobody-enzyme conjugate effectively activated the release of phenylenediamine mustard from the cephalosporin nitrogen mustard prodrug 7-(4-carboxybutanamido) cephalosporin mustard at the surface of carcinoembryonic antigen-expr …
In vitro experiments showed that the nanobody-enzyme conjugate effectively activated the release of phenylenediamine mustard f …
Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
Hay MP, Anderson RF, Ferry DM, Wilson WR, Denny WA. Hay MP, et al. J Med Chem. 2003 Dec 4;46(25):5533-45. doi: 10.1021/jm030308b. J Med Chem. 2003. PMID: 14640560
A variety of nitroheterocyclic carbamate prodrugs of phenylenediamine mustard and 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2-dihydro-3H-benz[e]indoline (amino-seco-CBI-TMI), covering a wide range of reduction potential, were prepared and e …
A variety of nitroheterocyclic carbamate prodrugs of phenylenediamine mustard and 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethox …
Regressions and cures of melanoma xenografts following treatment with monoclonal antibody beta-lactamase conjugates in combination with anticancer prodrugs.
Kerr DE, Schreiber GJ, Vrudhula VM, Svensson HP, Hellström I, Hellström KE, Senter PD. Kerr DE, et al. Cancer Res. 1995 Aug 15;55(16):3558-63. Cancer Res. 1995. PMID: 7627964
Cephalosporin doxorubicin (C-Dox) and 7-(4-carboxybutanamido)-cephalosporin mustard (CCM) are prodrugs that are catalytically converted by Enterobacter cloacae beta-lactamase (bL) to the active anticancer agents doxorubicin and phenylenediamine mustard, respectively …
Cephalosporin doxorubicin (C-Dox) and 7-(4-carboxybutanamido)-cephalosporin mustard (CCM) are prodrugs that are catalytically converted by E …
Plasmin-activated prodrugs for cancer chemotherapy. 1. Synthesis and biological activity of peptidylacivicin and peptidylphenylenediamine mustard.
Chakravarty PK, Carl PL, Weber MJ, Katzenellenbogen JA. Chakravarty PK, et al. J Med Chem. 1983 May;26(5):633-8. doi: 10.1021/jm00359a003. J Med Chem. 1983. PMID: 6221099
As an initial test of this hypothesis, we synthesized the peptidyl prodrugs of the anticancer drugs (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin, AT-125) and N,N-bis(2-chloroethyl)-p-phenylenediamine (phenylenediamine mustard) by m …
As an initial test of this hypothesis, we synthesized the peptidyl prodrugs of the anticancer drugs (alpha S, 5S)-alpha-amino-3-chloro-4,5-d …
Synthesis and characterization of monoclonal antibody-beta-lactamase conjugates.
Svensson HP, Wallace PM, Senter PD. Svensson HP, et al. Bioconjug Chem. 1994 May-Jun;5(3):262-7. doi: 10.1021/bc00027a012. Bioconjug Chem. 1994. PMID: 7918745
Lower concentrations of dimeric L6-beta L compared to L6-Fab'2-beta L were required to convert the prodrug 7-(phenylacetamido)-cephalosporin mustard into the cytotoxic drug phenylenediamine mustard. Localization studies were performed in nude mice with H2981 subcuta …
Lower concentrations of dimeric L6-beta L compared to L6-Fab'2-beta L were required to convert the prodrug 7-(phenylacetamido)-cephalosporin …
Comparison of recombinant and synthetically formed monoclonal antibody-beta-lactamase conjugates for anticancer prodrug activation.
Kerr DE, Vrudhula VM, Svensson HP, Siemers NO, Senter PD. Kerr DE, et al. Bioconjug Chem. 1999 Nov-Dec;10(6):1084-9. doi: 10.1021/bc990075w. Bioconjug Chem. 1999. PMID: 10563779
Results from in vitro experiments using two lung carcinoma cell lines demonstrated that the conjugates were equally active in effecting the release of phenylenediamine mustard from the cephalosporin nitrogen mustard prodrug CCM. ...
Results from in vitro experiments using two lung carcinoma cell lines demonstrated that the conjugates were equally active in effecting the …
Antitumor activities of a cephalosporin prodrug in combination with monoclonal antibody-beta-lactamase conjugates.
Vrudhula VM, Svensson HP, Kennedy KA, Senter PD, Wallace PM. Vrudhula VM, et al. Bioconjug Chem. 1993 Sep-Oct;4(5):334-40. doi: 10.1021/bc00023a005. Bioconjug Chem. 1993. PMID: 8274516
Both CM and CCM were hydrolyzed by purified beta-lactamases from Escherichia coli (EC beta L), Bacillus cereus (BC beta L), and Enterobacter cloacae (ECl beta L). This resulted in the release of phenylenediamine mustard (PDM), a potent cytotoxic drug. The Km and kca …
Both CM and CCM were hydrolyzed by purified beta-lactamases from Escherichia coli (EC beta L), Bacillus cereus (BC beta L), and Enterobacter …
Monoclonal antibody-beta-lactamase conjugates for the activation of a cephalosporin mustard prodrug.
Svensson HP, Kadow JF, Vrudhula VM, Wallace PM, Senter PD. Svensson HP, et al. Bioconjug Chem. 1992 Mar-Apr;3(2):176-81. doi: 10.1021/bc00014a013. Bioconjug Chem. 1992. PMID: 1515470
Purified beta-lactamases from Bacillus cereus (BC beta L) and Escherichia coli (EC beta L) catalyzed the release of phenylenediamine mustard (PDM) from CM through a fragmentation reaction which occurs after the beta-lactam ring of CM is hydrolyzed. ...
Purified beta-lactamases from Bacillus cereus (BC beta L) and Escherichia coli (EC beta L) catalyzed the release of phenylenediamine …
Synthesis and in vitro evaluation of macromolecular antitumour derivatives based on phenylenediamine mustard.
De Winne K, Seymour LW, Schacht EH. De Winne K, et al. Eur J Pharm Sci. 2005 Feb;24(2-3):159-68. doi: 10.1016/j.ejps.2004.09.006. Eur J Pharm Sci. 2005. PMID: 15661487
Poly-[N-(2-hydroxyethyl)-L-glutamine] (PHEG) and poly(ethylene glycol) (PEG)-grafted PHEG conjugates of N,N-di(2-chloroethyl)-4-phenylenediamine mustard (PDM) were synthetised. A collagenase-sensitive oligopeptide spacer was selected to link the cytotoxic agent PDM …
Poly-[N-(2-hydroxyethyl)-L-glutamine] (PHEG) and poly(ethylene glycol) (PEG)-grafted PHEG conjugates of N,N-di(2-chloroethyl)-4-phenylene …
12 results