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Year Number of Results
1991 2
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2004 2
2005 3
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2009 5
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43 results

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Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malaria transmission by silencing mosquito immunity.
Ramelow J, Keleta Y, Niu G, Wang X, Li J. Ramelow J, et al. J Biol Chem. 2023 Jun;299(6):104824. doi: 10.1016/j.jbc.2023.104824. Epub 2023 May 15. J Biol Chem. 2023. PMID: 37196765 Free PMC article.
Plasmodium falciparum is the most dominant and dangerous malaria pathogen. Previous studies identified a sexual stage-specific protein 16 (Pfs16) localized to the parasitophorous vacuole membrane. Here, we elucidate the function of Pfs16 during malaria transm …
Plasmodium falciparum is the most dominant and dangerous malaria pathogen. Previous studies identified a sexual stage-specific protein …
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein.
Yahiya S, Saunders CN, Hassan S, Straschil U, Fischer OJ, Rueda-Zubiaurre A, Haase S, Vizcay-Barrena G, Famodimu MT, Jordan S, Delves MJ, Tate EW, Barnard A, Fuchter MJ, Baum J. Yahiya S, et al. Dis Model Mech. 2023 Feb 1;16(2):dmm049950. doi: 10.1242/dmm.049950. Epub 2023 Jan 30. Dis Model Mech. 2023. PMID: 36715290 Free PMC article.
Photoaffinity labelling of probe 2 coupled with mass spectrometry identified the 16 kDa Plasmodium falciparum parasitophorous vacuole membrane protein Pfs16 as a potential parasite target. Complementary methods including cellular thermal shift assays confirmed that …
Photoaffinity labelling of probe 2 coupled with mass spectrometry identified the 16 kDa Plasmodium falciparum parasitophorous vacuole membra …
Induction of Plasmodium falciparum sporozoite-neutralizing antibodies upon vaccination with recombinant Pfs16 vaccinia virus and/or recombinant Pfs16 protein produced in yeast.
Moelans II, Cohen J, Marchand M, Molitor C, de Wilde P, van Pelt JF, Hollingdale MR, Roeffen WF, Eling WM, Atkinson CT, et al. Moelans II, et al. Mol Biochem Parasitol. 1995 Jun;72(1-2):179-92. doi: 10.1016/0166-6851(95)00072-9. Mol Biochem Parasitol. 1995. PMID: 8538688
Upon transformation of yeast cells, harbouring a genomic copy of the HBsAg gene, with a plasmid carrying the fusion gene Pfs16-HBsAg (Pfs16-S) virus-like hybrid particles composed of HBsAg and Pfs16-S were formed of a size similar to those present in human se …
Upon transformation of yeast cells, harbouring a genomic copy of the HBsAg gene, with a plasmid carrying the fusion gene Pfs16-HBsAg …
Studies of the Parasite-Midgut Interaction Reveal Plasmodium Proteins Important for Malaria Transmission to Mosquitoes.
Niu G, Cui Y, Wang X, Keleta Y, Li J. Niu G, et al. Front Cell Infect Microbiol. 2021 Jun 28;11:654216. doi: 10.3389/fcimb.2021.654216. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34262880 Free PMC article.
Previous works showed that among these interactive proteins, knockout the orthologs of Pfs37 or Pfs16 in P. berghei reduced oocysts in mosquitoes. Here we further found that anti-Pfs16 polyclonal antibody significantly inhibited P. falciparum transmission to …
Previous works showed that among these interactive proteins, knockout the orthologs of Pfs37 or Pfs16 in P. berghei reduced oo …
Protein targeting to the parasitophorous vacuole membrane of Plasmodium falciparum.
Eksi S, Williamson KC. Eksi S, et al. Eukaryot Cell. 2011 Jun;10(6):744-52. doi: 10.1128/EC.00008-11. Epub 2011 Apr 15. Eukaryot Cell. 2011. PMID: 21498641 Free PMC article.
The locations of Pfs16-green fluorescent protein (GFP) reporter proteins containing distinct regions of Pfs16 were tracked from RBC invasion to emergence. ...Additionally, during emergence from the PVM and RBC, native Pfs16 and the full-length …
The locations of Pfs16-green fluorescent protein (GFP) reporter proteins containing distinct regions of Pfs16 we …
[Clinical analysis of immunotherapy rechallenge in advanced gastric cancer].
Zhang XX, Yang XF, Li S, Wu C, Hou XF. Zhang XX, et al. Zhonghua Zhong Liu Za Zhi. 2023 Jul 23;45(7):605-612. doi: 10.3760/cma.j.cn112152-20220418-00261. Zhonghua Zhong Liu Za Zhi. 2023. PMID: 37462017 Chinese.
Objective: To evaluate the efficacy and influencing factors of programmed death protein 1 (PD-1) monoclonal antibody rechallenge therapy in advanced gastric cancer (GC). ...
Objective: To evaluate the efficacy and influencing factors of programmed death protein 1 (PD-1) monoclonal antibody rechallenge ther …
Cellular location and temporal expression of the Plasmodium falciparum sexual stage antigen Pfs16.
Bruce MC, Carter RN, Nakamura K, Aikawa M, Carter R. Bruce MC, et al. Mol Biochem Parasitol. 1994 May;65(1):11-22. doi: 10.1016/0166-6851(94)90111-2. Mol Biochem Parasitol. 1994. PMID: 7935618
The temporal expression during gametogenesis and the cellular location of the sexual stage specific protein Pfs16, a putative integral membrane protein of Plasmodium falciparum, was investigated using two monoclonal antibodies, 2G7 and 93A3A2. Using sorbitol …
The temporal expression during gametogenesis and the cellular location of the sexual stage specific protein Pfs16, a putative …
Developmentally regulated expression of pfs16, a marker for sexual differentiation of the human malaria parasite Plasmodium falciparum.
Dechering KJ, Thompson J, Dodemont HJ, Eling W, Konings RN. Dechering KJ, et al. Mol Biochem Parasitol. 1997 Nov;89(2):235-44. doi: 10.1016/s0166-6851(97)00123-0. Mol Biochem Parasitol. 1997. PMID: 9364968 Free article.
In the present work we describe the differential expression of the gene encoding the sexual stage specific protein, Pfs16. We have conducted a comparative analysis of pfs16 promoter activity, RNA levels and the rate of de novo protein synthesis during …
In the present work we describe the differential expression of the gene encoding the sexual stage specific protein, Pfs16. We …
Functional analysis of Plasmodium falciparum parasitophorous vacuole membrane protein (Pfs16) during gametocytogenesis and gametogenesis by targeted gene disruption.
Kongkasuriyachai D, Fujioka H, Kumar N. Kongkasuriyachai D, et al. Mol Biochem Parasitol. 2004 Feb;133(2):275-85. doi: 10.1016/j.molbiopara.2003.10.014. Mol Biochem Parasitol. 2004. PMID: 14698439
The earliest known gene product expressed at the onset of Plasmodium falciparum gametocytogenesis is Pfs16 localized on the parasitophorous vacuole membrane (PVM). Targeted gene disruption was undertaken to disrupt expression of Pfs16 and examine its potential role …
The earliest known gene product expressed at the onset of Plasmodium falciparum gametocytogenesis is Pfs16 localized on the parasitop …
43 results