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Novel inhibitors of superoxide anion generation, OPC-15160 and OPC-15161. Taxonomy, fermentation, isolation, physico-chemical properties, biological characteristics and structure determination.
Nakano Y, Kawaguchi T, Sumitomo J, Takizawa T, Uetsuki S, Sugawara M, Kido M. Nakano Y, et al. J Antibiot (Tokyo). 1991 Jan;44(1):52-8. doi: 10.7164/antibiotics.44.52. J Antibiot (Tokyo). 1991. PMID: 1848216 Free article.
OPC-15161 was five times more active than the natural inhibitor and its IC50 value was 2.8 x 10(-5) M. The structure of OPC-15161 was elucidated by X-ray analysis to be 6-(1H-indol-3-ylmethyl)-5-methoxy-3- (2-methylpropyl)-2-(1H)-pyrazinone, 4-oxide an …
OPC-15161 was five times more active than the natural inhibitor and its IC50 value was 2.8 x 10(-5) M. The structure of OPC …
OPC-15161 suppresses the proliferation of Tenon's capsule fibroblasts and the production of type I collagen and fibronectin stimulated by TGF-beta1 in vitro.
Saika S, Yamanaka O, Kawashima Y, Ohkawa K, Ohnishi Y, Ooshima A, Kimura M, Nakano Y, Kao WW. Saika S, et al. Curr Eye Res. 1998 Sep;17(9):933-40. doi: 10.1076/ceyr.17.9.933.5142. Curr Eye Res. 1998. PMID: 9746441
OPC-15161 did not affect the laminin or total protein content, either with or without TGF-beta1. ...OPC-15161 may be useful in inhibiting the excessive fibrosis produced in the wound in response to filtering surgery....
OPC-15161 did not affect the laminin or total protein content, either with or without TGF-beta1. ...OPC-15161 ma …
Inhibitory effect of OPC-15161, a component of fungus Thielavia minor, on proliferation and extracellular matrix production of rat cultured hepatic stellate cells.
Sugawara H, Ueno T, Torimura T, Inuzuka S, Tanikawa K. Sugawara H, et al. J Cell Physiol. 1998 Mar;174(3):398-406. doi: 10.1002/(SICI)1097-4652(199803)174:3<398::AID-JCP14>3.0.CO;2-5. J Cell Physiol. 1998. PMID: 9462702
IL-1beta significantly increased the uptake of [3H]thymidine in the HSCs, and the addition of OPC-15161 inhibited the uptake in a dose-dependent manner. The cell number of HSCs was also increased by IL-1beta, which was inhibited by OPC-15161. ...TGF-be …
IL-1beta significantly increased the uptake of [3H]thymidine in the HSCs, and the addition of OPC-15161 inhibited the uptake i …
The radical scavenging abilities of a new anti-nephritic drug, OPC-15161.
Ozawa T, Nakano Y. Ozawa T, et al. Biochem Mol Biol Int. 1996 Feb;38(2):231-8. Biochem Mol Biol Int. 1996. PMID: 8850518
A new anti-nephritic drug, 6-(1H-indol-3-ylmethyl)-5-methoxy-3-(2-methylpropyl)-2-(1H)-pyr azi none 4-oxide (OPC-15161), a natural product derivative, did not react with the free radical, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and was only slightly reactive with super …
A new anti-nephritic drug, 6-(1H-indol-3-ylmethyl)-5-methoxy-3-(2-methylpropyl)-2-(1H)-pyr azi none 4-oxide (OPC-15161), a nat …
Therapeutic effect of a newly developed antioxidative agent (OPC-15161) on experimental immune complex nephritis.
Sanaka T, Nakano Y, Nishimura H, Shinobe M, Higuchi C, Omata M, Nihei H, Sugino N. Sanaka T, et al. Nephron. 1997;76(3):315-22. doi: 10.1159/000190198. Nephron. 1997. PMID: 9226233
The effect of a newly developed free radical scavenger (OPC-15161) on the progression of nephrotoxic serum (NTS) nephritis was evaluated. ...The effects of OPC-15161, dipyridamole, and prednisolone on NTS nephritis rats were investigated. ...
The effect of a newly developed free radical scavenger (OPC-15161) on the progression of nephrotoxic serum (NTS) nephritis was …