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1983 1
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Peripheral cardiovascular alpha- and beta-adrenergic effects of some hypotensive and bradycardic arylalkyl imidazole derivatives in the rat.
Savola JM, Puurunen J, Ruskoaho H, Kärki NT. Savola JM, et al. J Pharm Pharmacol. 1985 Jun;37(6):410-4. doi: 10.1111/j.2042-7158.1985.tb03025.x. J Pharm Pharmacol. 1985. PMID: 2862264
These effects were induced in the order of potency clonidine = MPV 207 greater than MPV 295 greater than MPV 304 greater than MPV 390, correlating with the length of the alkyl bridge between the phenyl and imidazole moieties. The peripheral postsynaptic actions of …
These effects were induced in the order of potency clonidine = MPV 207 greater than MPV 295 greater than MPV 304 greater than …
Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoreceptors.
Savola JM, Ruskoaho H, Puurunen J, Salonen JS, Kärki NT. Savola JM, et al. J Auton Pharmacol. 1986 Dec;6(4):275-84. doi: 10.1111/j.1474-8673.1986.tb00654.x. J Auton Pharmacol. 1986. PMID: 2880852
The activity on alpha-adrenoreceptors of medetomidine ((+/-)-4-(alpha,2,3-trimethylbenzyl)imidazole), an alpha-methyl derivative of detomidine, has been characterized in vivo and in vitro using detomidine, MPV 207, MPV 295, azepexole, clonidine and xylazine for refe …
The activity on alpha-adrenoreceptors of medetomidine ((+/-)-4-(alpha,2,3-trimethylbenzyl)imidazole), an alpha-methyl derivative of detomidi …
A comparative study on hypotensive and bradycardic effects of some new imidazole derivatives with possible central mechanism of action.
Puurunen J, Ruskoaho H, Kärki NT, Karjalainen A, Kurkela K. Puurunen J, et al. Arch Int Pharmacodyn Ther. 1983 Jan;261(1):102-8. Arch Int Pharmacodyn Ther. 1983. PMID: 6847311
Cardiovascular actions of 4(5)-(2,6-dimethylbenzyl)imidazole (MPV-207) and its three alkyl bridge analogues were investigated in urethane-anaesthetized normotensive rats. Intravenous (i.v.) injections of 0.001-0.1 mg/kg of …
Cardiovascular actions of 4(5)-(2,6-dimethylbenzyl)imidazole (MPV-207) and its three …