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1978 2
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Effect of the oral hypoglycemic agent pirogliride (McN-3495) on glycogen levels of normal and diabetic rats.
Tutwiler GF, Fawthrop H. Tutwiler GF, et al. Biochem Int. 1983 Jul;7(1):55-62. Biochem Int. 1983. PMID: 6383388
Pirogliride, a new oral hypoglycemic agent unrelated structurally or mechanistically to either the sulfonylureas or biguanides, produced a dose-dependent increase in liver but not muscle glycogen levels of fasted non-diabetic rats and produced at 100 mg/kg, p.o. a modest i …
Pirogliride, a new oral hypoglycemic agent unrelated structurally or mechanistically to either the sulfonylureas or biguanides, produ …
A pharmacologic profile of McN-3495 [N-(1-methyl-2-pyrrolidinylidene)-N'-phenyl-1-pyrrolidinecarboximidamide], a new, orally effective hypoglycemic agent.
Tutwiler GF, Kirsch T, Bridi G. Tutwiler GF, et al. Diabetes. 1978 Aug;27(8):856-67. doi: 10.2337/diab.27.8.856. Diabetes. 1978. PMID: 98377
McN-3495, a new compound unrelated strucuturally to the sulfonylureas or phenformin, has been found to produce a hypoglycemic effect in nondiabetic rats, dogs, mice, and monkeys. ...However, McN-3495, as phenformin, fails to work in totally depancreati …
McN-3495, a new compound unrelated strucuturally to the sulfonylureas or phenformin, has been found to produce a hypoglycemic …
Postreceptor regulation of insulin action in primary cultures of rat hepatocytes by oral hypoglycemic agents: effects of linogliride and chlorpropamide.
Salhanick AI, Leighty SJ, Amatruda JM. Salhanick AI, et al. Horm Metab Res. 1989 Nov;21(11):596-601. doi: 10.1055/s-2007-1009297. Horm Metab Res. 1989. PMID: 2687145
We have previously demonstrated the ability of the sulfonylurea tolazamide to potentiate insulin action in primary cultures of hepatocytes prepared from normal and streptozotocin-diabetic rats. To determine whether the pirogliride derivative linogliride, a non-sulfonylurea …
We have previously demonstrated the ability of the sulfonylurea tolazamide to potentiate insulin action in primary cultures of hepatocytes p …
Pirogliride: an oral hypoglycemic drug which accelerates glucose usage and insulin secretion by islets of Langerhans.
Zawalich WS, Weill VA, Matschinsky FM. Zawalich WS, et al. Diabetes. 1980 May;29(5):410-2. doi: 10.2337/diab.29.5.410. Diabetes. 1980. PMID: 6991332
Pirogliride potentiates glucose-induced insulin secretion from isolated islets. This effect is accompanied by a facilitated glucose metabolism. Pirogliride partially prevents the known inhibitory effects of mannoheptulose on glucose-induced secretion and utilization …
Pirogliride potentiates glucose-induced insulin secretion from isolated islets. This effect is accompanied by a facilitated glucose m …
Metabolic fate of the hypoglycemic agent pirogliride in laboratory animals and humans.
Wu WN. Wu WN. J Pharm Biomed Anal. 1998 Aug;17(4-5):689-97. doi: 10.1016/s0731-7085(97)00252-5. J Pharm Biomed Anal. 1998. PMID: 9682152
Metabolism of the hypoglycemic agent, pirogliride, was investigated in the rat, dog monkey and human. Unchanged pirogliride plus six metabolites were isolated and identified using solvent extraction, HPLC and CI and EI-MS from urine and fecal samples. Pirogliride …
Metabolism of the hypoglycemic agent, pirogliride, was investigated in the rat, dog monkey and human. Unchanged pirogliride pl …
11 results