Synthesis of antimicrobial glucosamides as bacterial quorum sensing mechanism inhibitors.
Biswas NN, Yu TT, Kimyon Ö, Nizalapur S, Gardner CR, Manefield M, Griffith R, Black DS, Kumar N.
Biswas NN, et al.
Bioorg Med Chem. 2017 Feb 1;25(3):1183-1194. doi: 10.1016/j.bmc.2016.12.024. Epub 2016 Dec 21.
Bioorg Med Chem. 2017.
PMID: 28049617
All of the synthesized compounds were tested against two bacterial strains, P. aeruginosa MH602 (LasI/R-type QS) and E. coli MT102 (LuxI/R-type QS), for QS inhibitory activity. The most active compound 9b showed 79.1% QS inhibition against P. aeruginosa MH602 and 98.4% aga …
All of the synthesized compounds were tested against two bacterial strains, P. aeruginosa MH602 (LasI/R-type QS) and E. coli MT102 (L …