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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 5
1981 13
1982 32
1983 91
1984 83
1985 82
1986 100
1987 130
1988 118
1989 117
1990 118
1991 106
1992 93
1993 95
1994 102
1995 86
1996 77
1997 71
1998 85
1999 46
2000 57
2001 84
2002 75
2003 61
2004 61
2005 61
2006 66
2007 60
2008 70
2009 67
2010 46
2011 42
2012 54
2013 56
2014 46
2015 47
2016 53
2017 31
2018 43
2019 37
2020 32
2021 31
2022 22
2023 15
2024 7

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2,746 results

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Page 1
Cysteinyl leukotriene receptors.
Evans JF. Evans JF. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:587-97. doi: 10.1016/s0090-6980(02)00057-6. Prostaglandins Other Lipid Mediat. 2002. PMID: 12432945 Review.
The cysteinyl leukotrienes, leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4), activate contractile and inflammatory processes via specific interaction with putative seven transmembrane-spanning receptors that couple to G proteins …
The cysteinyl leukotrienes, leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4), activate con …
Leukotriene D4 induces cellular senescence in osteoblasts.
Wei J, Chen S, Guo W, Feng B, Yang S, Huang C, Chu J. Wei J, et al. Int Immunopharmacol. 2018 May;58:154-159. doi: 10.1016/j.intimp.2017.12.027. Epub 2018 Mar 26. Int Immunopharmacol. 2018. PMID: 29587204
Aging is associated with the development of osteoporosis, in which cellular senescence in osteoblasts plays a key role. Leukotriene D4 (LTD4), an important cysteinyl leukotriene (cysLT), is a powerful pro-inflammatory mediator formed from arachidonic acid. .. …
Aging is associated with the development of osteoporosis, in which cellular senescence in osteoblasts plays a key role. Leukotriene …
Leukotriene D4 accelerates antigen-mediated mast cell responses via the cysteinyl leukotriene 1 receptor.
Fujisawa S, Nagata Y, Suzuki R. Fujisawa S, et al. Cell Immunol. 2022 Dec;382:104632. doi: 10.1016/j.cellimm.2022.104632. Epub 2022 Oct 17. Cell Immunol. 2022. PMID: 36274438
The use of CysLT1R and CysLT2R inhibitors revealed that CysLT1R plays a major role in the acceleration of MC activation. The administration of the CysLT1R agonist leukotriene D4 upregulated IgE-mediated Akt and ERK phosphorylation and subsequently enhanced TNF-alpha …
The use of CysLT1R and CysLT2R inhibitors revealed that CysLT1R plays a major role in the acceleration of MC activation. The administration …
Leukotriene D4-induced signal transduction.
Sjölander A, Grönroos E. Sjölander A, et al. Ann N Y Acad Sci. 1994 Nov 15;744:155-60. doi: 10.1111/j.1749-6632.1994.tb52732.x. Ann N Y Acad Sci. 1994. PMID: 7825836 Review.
Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption.
Fujita H, Ando A, Mizusawa Y, Ono M, Hattori T, Habuta M, Oohashi T, Kubota S, Ohuchi H. Fujita H, et al. PLoS One. 2022 Nov 17;17(11):e0277307. doi: 10.1371/journal.pone.0277307. eCollection 2022. PLoS One. 2022. PMID: 36395281 Free PMC article.
Bone marrow macrophages (BMM) from these mutant mice lost the intracellular flux of calcium in response to leukotriene D4, indicating that these mutants completely lost the activity of CysLTR1 without triggering genetic compensation. ...Collectively, these results s …
Bone marrow macrophages (BMM) from these mutant mice lost the intracellular flux of calcium in response to leukotriene D4, ind …
Leukotriene D4 inhalation challenge for predicting short-term efficacy of montelukast: a pilot study.
Guan WJ, Shi X, Zheng JP, Gao Y, Jiang CY, Xie YQ, Liu QX, Zhu Z, Guo E, An JY, Yu XX, Liu WT, Zhong NS. Guan WJ, et al. Clin Respir J. 2015 Jan;9(1):111-20. doi: 10.1111/crj.12117. Epub 2014 Mar 5. Clin Respir J. 2015. PMID: 24506412 Clinical Trial.
INTRODUCTION: The convenient measure to predict efficacy of leukotriene receptor antagonist is lacking. OBJECTIVES: To determine if leukotriene D4 inhalation challenge predicts short-term efficacy of montelukast in asthma. METHODS: In this open-labelled 28-da …
INTRODUCTION: The convenient measure to predict efficacy of leukotriene receptor antagonist is lacking. OBJECTIVES: To determine if …
Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes.
Guan W, Zheng J, Gao Y, Jiang C, Xie Y, An J, Yu X, Liu W, Zhong N. Guan W, et al. J Allergy Clin Immunol. 2013 Feb;131(2):332-8.e1-4. doi: 10.1016/j.jaci.2012.08.020. Epub 2012 Oct 4. J Allergy Clin Immunol. 2013. PMID: 23040886 Clinical Trial.
Asthmatic patients with a lower cumulative dose for LTD(4) and a higher leukotriene/methacholine potency ratio than geometric means were regarded as leukotriene responsive. ...The combination of cumulative dose for LTD(4) and potency ratio might be useful to identif …
Asthmatic patients with a lower cumulative dose for LTD(4) and a higher leukotriene/methacholine potency ratio than geometric means w …
Allergy and asthma.
Bochner BS, Busse WW. Bochner BS, et al. J Allergy Clin Immunol. 2005 May;115(5):953-9. doi: 10.1016/j.jaci.2005.02.032. J Allergy Clin Immunol. 2005. PMID: 15867851 Review.
Functional characteristics of cysteinyl-leukotriene receptor subtypes.
Bäck M. Bäck M. Life Sci. 2002 Jun 28;71(6):611-22. doi: 10.1016/s0024-3205(02)01733-2. Life Sci. 2002. PMID: 12072150 Review.
Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent Cys …
Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictor …
Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle.
Jonsson EW. Jonsson EW. Acta Physiol Scand Suppl. 1998 Mar;641:1-55. Acta Physiol Scand Suppl. 1998. PMID: 9597121 Review.
In the guinea pig ileum, BAY u9773 but not the selective CysLT1 receptor antagonist ICI 198,615 inhibited the contractile response to leukotriene C4 in a fashion suggesting competitive antagonism. In sheep trachealis muscle, BAY u9773 antagonised contractions induced by …
In the guinea pig ileum, BAY u9773 but not the selective CysLT1 receptor antagonist ICI 198,615 inhibited the contractile response to leu …
2,746 results