Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 2
1992 1
1993 1
1994 1
1995 9
1996 24
1997 60
1998 84
1999 100
2000 138
2001 133
2002 127
2003 123
2004 112
2005 117
2006 112
2007 99
2008 105
2009 73
2010 71
2011 59
2012 54
2013 38
2014 43
2015 50
2016 31
2017 33
2018 22
2019 25
2020 13
2021 9
2022 8
2023 9
2024 3

Text availability

Article attribute

Article type

Publication date

Search Results

1,716 results

Results by year

Filters applied: . Clear all
Page 1
Viral entry and the ubiquitin-proteasome system.
Schneider SM, Lee BH, Nicola AV. Schneider SM, et al. Cell Microbiol. 2021 Feb;23(2):e13276. doi: 10.1111/cmi.13276. Epub 2020 Oct 26. Cell Microbiol. 2021. PMID: 33037857 Review.
Inhibitors of proteasome activity, including MG132, epoxomicin, lactacystin and bortezomib have been integral to developments in this area. ...
Inhibitors of proteasome activity, including MG132, epoxomicin, lactacystin and bortezomib have been integral to developments in this …
Lactacystin: first-in-class proteasome inhibitor still excelling and an exemplar for future antibiotic research.
Ōmura S, Crump A. Ōmura S, et al. J Antibiot (Tokyo). 2019 Apr;72(4):189-201. doi: 10.1038/s41429-019-0141-8. Epub 2019 Feb 12. J Antibiot (Tokyo). 2019. PMID: 30755736 Free PMC article. Review.
Lactacystin exemplifies the role that serendipity plays in drug discovery and why "finding things without actually looking for them" retains such a pivotal role in the search for the useful properties of chemicals. The first proteasome inhibitor discovered, lactacystin
Lactacystin exemplifies the role that serendipity plays in drug discovery and why "finding things without actually looking for them"
Lactacystin, a proteasome inhibitor: discovery and its application in cell biology.
Tomoda H, Omura S. Tomoda H, et al. Yakugaku Zasshi. 2000 Oct;120(10):935-49. doi: 10.1248/yakushi1947.120.10_935. Yakugaku Zasshi. 2000. PMID: 11082705 Review.
Lactacystin was isolated from the culture broth of Streptomyces lactacystinaeus as an inducer of neurite outgrowth in Neuro 2a cells (a mouse neuroblastoma cell line). ...Lactacystin and its cell-permeable beta-lactone form, later designated omuralide by Prof. ...
Lactacystin was isolated from the culture broth of Streptomyces lactacystinaeus as an inducer of neurite outgrowth in Neuro 2a cells
Lactacystin, proteasome function, and cell fate.
Fenteany G, Schreiber SL. Fenteany G, et al. J Biol Chem. 1998 Apr 10;273(15):8545-8. doi: 10.1074/jbc.273.15.8545. J Biol Chem. 1998. PMID: 9535824 Free article. Review. No abstract available.
Effect of sacubitril/valsartan on the hypertensive heart in continuous light-induced and lactacystin-induced pre-hypertension: Interactions with the renin-angiotensin-aldosterone system.
Simko F, Stanko P, Repova K, Baka T, Krajcirovicova K, Aziriova S, Domenig O, Zorad S, Adamcova M, Paulis L. Simko F, et al. Biomed Pharmacother. 2024 Apr;173:116391. doi: 10.1016/j.biopha.2024.116391. Epub 2024 Mar 11. Biomed Pharmacother. 2024. PMID: 38461685 Free article.
Nine groups of three-month-old male Wistar rats were treated for six weeks as follows: untreated controls (C), sacubitril/valsartan (ARNI), valsartan (Val), continuous light (24), continuous light plus sacubitril/valsartan (24+ARNI) or valsartan (24+Val), lactacystin (Lact …
Nine groups of three-month-old male Wistar rats were treated for six weeks as follows: untreated controls (C), sacubitril/valsartan (ARNI), …
Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril.
Simko F, Pechanova O, Repova K, Aziriova S, Krajcirovicova K, Celec P, Tothova L, Vrankova S, Balazova L, Zorad S, Adamcova M. Simko F, et al. Int J Mol Sci. 2017 Jul 25;18(8):1612. doi: 10.3390/ijms18081612. Int J Mol Sci. 2017. PMID: 28757582 Free PMC article.
Lactacystin is a proteasome inhibitor that interferes with several factors involved in heart remodelling. ...Six groups of three-month-old male Wistar rats (11 per group) were treated for six weeks as follows: control (vehicle), L-NAME (40 mg/kg/day), continuous light (24
Lactacystin is a proteasome inhibitor that interferes with several factors involved in heart remodelling. ...Six groups of three-mont
Total synthesis of lactacystin and salinosporamide A.
Shibasaki M, Kanai M, Fukuda N. Shibasaki M, et al. Chem Asian J. 2007 Jan 8;2(1):20-38. doi: 10.1002/asia.200600310. Chem Asian J. 2007. PMID: 17441136 Review.
Lactacystin and salinosporamide A are fascinating molecules with regard to both their chemical structures and biological activities. ...
Lactacystin and salinosporamide A are fascinating molecules with regard to both their chemical structures and biological activities.
[(18)F]FP-(+)-DTBZ PET study in a lactacystin-treated rat model of Parkinson disease.
Weng CC, Huang SL, Chen ZA, Lin KJ, Hsiao IT, Yen TC, Kung MP, Wey SP, Hsu CH. Weng CC, et al. Ann Nucl Med. 2017 Aug;31(7):506-513. doi: 10.1007/s12149-017-1174-3. Epub 2017 Apr 27. Ann Nucl Med. 2017. PMID: 28451991
OBJECTIVE: Lactacystin has been used to establish rodent models of Parkinson disease (PD), with cerebral alpha-synuclein inclusions. ...RESULTS: Both the 2- and 5-mug lactacystin-treated groups exhibited significantly decreased specific [(18)F]FP-(+)-DTBZ uptake in …
OBJECTIVE: Lactacystin has been used to establish rodent models of Parkinson disease (PD), with cerebral alpha-synuclein inclusions. …
Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin.
Kim TH, Yoo YH, Kang DY, Suh H, Park MK, Park KJ, Kim SH. Kim TH, et al. Int J Oncol. 2009 May;34(5):1353-62. Int J Oncol. 2009. PMID: 19360347
The present study investigated the mechanism underlying the antitumor activity of the histone deacetylases inhibitor valproic acid (VPA), alone and in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative (HS-1200), or the proteasome inhibitor lactacystin
The present study investigated the mechanism underlying the antitumor activity of the histone deacetylases inhibitor valproic acid (VPA), al …
Lactacystin, a proteasome inhibitor, enhances BMP-induced osteoblastic differentiation by increasing active Smads.
Ito Y, Fukushima H, Katagiri T, Seo Y, Hirata S, Zhang M, Hosokawa R, Jimi E. Ito Y, et al. Biochem Biophys Res Commun. 2011 Apr 1;407(1):225-9. doi: 10.1016/j.bbrc.2011.03.003. Epub 2011 Mar 4. Biochem Biophys Res Commun. 2011. PMID: 21377449
Pretreatment with lactacystin enhanced the alkaline phosphatase (ALP) activity induced by BMP2, BMP4 or BMP7, but lactacystin did not induce ALP in the absence of BMPs. ...Moreover, lactacystin prevented BMP receptor-induced Smad degradation. This enhancement …
Pretreatment with lactacystin enhanced the alkaline phosphatase (ALP) activity induced by BMP2, BMP4 or BMP7, but lactacystin
1,716 results