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Rifalazil(Kaneka corp).
IDrugs. 1998 Sep;1(5):599-604.
IDrugs. 1998.
PMID: 18465600
In preclinical in vitro studies, rifalazil was 30-fold more potent than rifampin against M tuberculosis and MAC, and has shown efficacy in animal models of tuberculosis and in disseminated MAC infections that have been predictive of clinical efficacy with other antibiotics [22416 …
In preclinical in vitro studies, rifalazil was 30-fold more potent than rifampin against M tuberculosis and MAC, and has shown efficacy in a …
In vitro metabolism of a rifamycin derivative by animal and human liver microsomes, whole blood and expressed human CYP3A isoform.
Mae T, Hosoe K, Fujii K, Yamashita K, Yamane T, Hidaka T, Ohashi T.
Mae T, et al.
Xenobiotica. 1996 Aug;26(8):793-802. doi: 10.3109/00498259609046749.
Xenobiotica. 1996.
PMID: 8879143
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High-performance liquid chromatographic determination of 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin (KRM-1648) and its deacetyl metabolite in plasma, whole blood, urine and tissue samples in rats.
Hosoe K, Konishi E, Hidaka T, Yamane T, Yamashita K, Ohashi T.
Hosoe K, et al.
J Chromatogr B Biomed Appl. 1994 Mar 4;653(2):177-86. doi: 10.1016/0378-4347(93)e0431-o.
J Chromatogr B Biomed Appl. 1994.
PMID: 8205245
A reversed-phase high-performance liquid chromatographic method was developed for the determination of 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin (KRM-1648, I), a new rifamycin derivative, and its 25-deacetyl metabolite (KRM-1671, II) in plasma, wh …
A reversed-phase high-performance liquid chromatographic method was developed for the determination of 3'-hydroxy-5'-(4-isobutyl-1-piperazin …
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