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Pharmacokinetics of yunaconitine and indaconitine in mouse blood by UPLC-MS/MS.
Yu X, Liu H, Xu X, Hu Y, Wang X, Wen C. Yu X, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Aug 1;1179:122840. doi: 10.1016/j.jchromb.2021.122840. Epub 2021 Jun 19. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 34225245
Yunaconitine and indaconitine are active ingredients from the rhizomes of Aconitum plants. ...The UPLC-MS/MS method developed herein was successfully applied to measuring the pharmacokinetic parameters of yunaconitine and indaconitine in mice after intravenous and o …
Yunaconitine and indaconitine are active ingredients from the rhizomes of Aconitum plants. ...The UPLC-MS/MS method developed herein …
Attenuated Structural Transformation of Indaconitine during Sand Frying Process and Anti-Arrhythmic Effects of Its Transformed Products.
Wang Y, Tao P, Wang YJ. Wang Y, et al. Evid Based Complement Alternat Med. 2022 Feb 17;2022:8606459. doi: 10.1155/2022/8606459. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 35222676 Free PMC article.
The aims of the study were to investigate the transformation pathways of indaconitine in the sand frying process, as well as examine the cardiotoxicity and anti-arrhythmic activity of indaconitine and its transformed products. ...Consequently, delta(15(16))-16-demet …
The aims of the study were to investigate the transformation pathways of indaconitine in the sand frying process, as well as examine …
[Diterpenoid alkaloids from roots of Aconitum kongboense].
Xie CY, Huang S, Chen L, Gao F, Zhou XL. Xie CY, et al. Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(17):4424-4432. doi: 10.19540/j.cnki.cjcmm.20210622.201. Zhongguo Zhong Yao Za Zhi. 2021. PMID: 34581046 Chinese.
., acotarine F(2), acotarine G(3), 14-acetyltalatisamine(4), talatisamine(5), indaconitine(6), yunaconitine(7), chasmanine(8), 6-epi-foresticine(9), homochasmanine(10), 8-deacetyl-yunaconitine(11), chasmaconitine(12), ajaconine(13), franchetine(14), ezochasmanine(15), cras …
., acotarine F(2), acotarine G(3), 14-acetyltalatisamine(4), talatisamine(5), indaconitine(6), yunaconitine(7), chasmanine(8), 6-epi- …
[Quality consistency evaluation of Fuzi formula granules using determination of multi-component contents by HPLC-MS/MS method].
Tang JF, Zhang SQ, Wang XY, Li WX, He YN, Cao ZX, Zhang DK. Tang JF, et al. Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1871-1879. doi: 10.19540/j.cnki.cjcmm.20180208.006. Zhongguo Zhong Yao Za Zhi. 2018. PMID: 29902899 Chinese.
The mass spectrum was scanned by ESI+ multiple reaction monitoring (MRM) mode. The contents of aconitine, mesaconitine, hypaconitine, Indaconitine, benzoylaconine, benzoylmesaconine, benzoylhypaconitine, aconine, fuziline, neoline, talatisamine, songorine, higenamine and s …
The mass spectrum was scanned by ESI+ multiple reaction monitoring (MRM) mode. The contents of aconitine, mesaconitine, hypaconitine, Ind …
Antileishmanial diterpenoid alkaloids from Aconitum spicatum (Bruhl) Stapf.
Shyaula SL, Tamang T, Ghouri N, Adhikari A, Marasini S, Bajracharya GB, Manandhar MD, Choudhary MI. Shyaula SL, et al. Nat Prod Res. 2016 Nov;30(22):2590-2593. doi: 10.1080/14786419.2015.1114941. Epub 2015 Nov 30. Nat Prod Res. 2016. PMID: 26615865
Chromatographic purification of the dichloromethane extract led to isolation of three C-19 norditerpenoid alkaloids indaconitine (1), chasmaconitine (2) and ludaconitine (3). Compounds 3 and 2 showed antileishmanial activity with IC(50) = 36.10 3.4 and 56.30 2.1 mug/mL, re …
Chromatographic purification of the dichloromethane extract led to isolation of three C-19 norditerpenoid alkaloids indaconitine (1), …
Compatibility of Fuzi and Ginseng Significantly Increase the Exposure of Aconitines.
Chen ZY, Wei XY, Qiu ZD, Huang Y, Tan T, Feng YL, Guo J, Cui GH, Huang LQ, Lai CJ. Chen ZY, et al. Front Pharmacol. 2022 Apr 26;13:883898. doi: 10.3389/fphar.2022.883898. eCollection 2022. Front Pharmacol. 2022. PMID: 35662724 Free PMC article.
Eight representative diester, monoester, and non-ester aconitines and two new active components (i.e., songorine and indaconitine) were all adopted to elucidating the differences of the pharmacokinetic parameters in vivo. ...
Eight representative diester, monoester, and non-ester aconitines and two new active components (i.e., songorine and indaconitine) we …
Acotarines A-G, new diterpenoid alkaloids from Aconitum taronense induce lysosomal biogenesis.
Si Y, Ding X, Adelakuna TA, Zhang Y, Hao XJ. Si Y, et al. Fitoterapia. 2020 Nov;147:104738. doi: 10.1016/j.fitote.2020.104738. Epub 2020 Oct 5. Fitoterapia. 2020. PMID: 33031866
All the compounds were tested for their activities to induce lysosomal biogenesis through LysoTracker Red staining, compounds acotarines B (2), E (5), F (6), indaconitine (8), 7,8-epoxy-franchetine (9), and 6-epiforesticine (10) showed inducing lysosomal biogenesis activit …
All the compounds were tested for their activities to induce lysosomal biogenesis through LysoTracker Red staining, compounds acotarines B ( …
Hemsleyatine, a novel C19-diterpenoid alkaloid with 8-amino group from Aconitum hemsleyanum.
Zhou XL, Chen QH, Chen DL, Wang FP. Zhou XL, et al. Chem Pharm Bull (Tokyo). 2003 May;51(5):592-4. doi: 10.1248/cpb.51.592. Chem Pharm Bull (Tokyo). 2003. PMID: 12736463 Free article.
The new compound hemsleyatine (1) was isolated along with four known C(19)-diterpenoid alkaloids: indaconitine (4), yunaconitine (5), chasmanine (6), and talatisamine (7) from the roots of Aconitum hemsleyanum PRITZ. ...
The new compound hemsleyatine (1) was isolated along with four known C(19)-diterpenoid alkaloids: indaconitine (4), yunaconitine (5), …