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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 2
1965 1
1966 2
1967 1
1968 1
1969 3
1970 2
1971 1
1973 2
1975 2
1976 1
1977 2
1978 3
1979 9
1980 10
1981 16
1982 17
1983 21
1984 29
1985 54
1986 64
1987 58
1988 103
1989 139
1990 156
1991 191
1992 207
1993 182
1994 79
1995 92
1996 76
1997 77
1998 81
1999 74
2000 68
2001 81
2002 74
2003 67
2004 79
2005 61
2006 71
2007 55
2008 62
2009 59
2010 52
2011 47
2012 49
2013 38
2014 36
2015 48
2016 34
2017 29
2018 33
2019 25
2020 21
2021 16
2022 17
2023 12
2024 2

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2,759 results

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Page 1
Fungal hallucinogens psilocin, ibotenic acid, and muscimol: analytical methods and biologic activities.
Stebelska K. Stebelska K. Ther Drug Monit. 2013 Aug;35(4):420-42. doi: 10.1097/FTD.0b013e31828741a5. Ther Drug Monit. 2013. PMID: 23851905 Review.
Psychoactive drugs of fungal origin, psilocin, ibotenic acid, and muscimol among them have been proposed for recreational use and popularized since the 1960s, XX century. ...The present article offers an opportunity to find out what are the main symptoms of intoxica …
Psychoactive drugs of fungal origin, psilocin, ibotenic acid, and muscimol among them have been proposed for recreational use …
Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation.
Obermaier S, Müller M. Obermaier S, et al. Angew Chem Int Ed Engl. 2020 Jul 20;59(30):12432-12435. doi: 10.1002/anie.202001870. Epub 2020 Jun 5. Angew Chem Int Ed Engl. 2020. PMID: 32233056 Free PMC article.
The hydroxylase gene is surrounded by six further biosynthetic genes, which we link to the production of ibotenic acid and muscimol using recent genomic and transcriptomic data. Our results pinpoint the genetic basis for ibotenic acid formation and thu …
The hydroxylase gene is surrounded by six further biosynthetic genes, which we link to the production of ibotenic acid and mus …
Amanita muscaria: chemistry, biology, toxicology, and ethnomycology.
Michelot D, Melendez-Howell LM. Michelot D, et al. Mycol Res. 2003 Feb;107(Pt 2):131-46. doi: 10.1017/s0953756203007305. Mycol Res. 2003. PMID: 12747324 Review.
The main species responsible are Amanita muscaria and A. pantherina (Amanitaceae); however, some other species of the genus have been suspected for similar actions. Ibotenic acid and muscimol are the active components, and probably, some other substances detected in …
The main species responsible are Amanita muscaria and A. pantherina (Amanitaceae); however, some other species of the genus have been suspec …
Hallucinogens and dissociative agents naturally growing in the United States.
Halpern JH. Halpern JH. Pharmacol Ther. 2004 May;102(2):131-8. doi: 10.1016/j.pharmthera.2004.03.003. Pharmacol Ther. 2004. PMID: 15163594 Review.
This article reviews plants containing N,N-dimethyltryptamine, reversible type A monoamine oxidase inhibitors (MAOI), lysergic acid amide, the anticholinergic drugs atropine and scopolamine, or the diterpene salvinorin-A (Salvia divinorum). Also reviewed are mescaline-cont …
This article reviews plants containing N,N-dimethyltryptamine, reversible type A monoamine oxidase inhibitors (MAOI), lysergic acid a …
Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design.
Krogsgaard-Larsen P, Hansen JJ. Krogsgaard-Larsen P, et al. Toxicol Lett. 1992 Dec;64-65 Spec No:409-16. doi: 10.1016/0378-4274(92)90214-5. Toxicol Lett. 1992. PMID: 1335179 Review.
The central excitatory neurotransmitter (S)-glutamic acid (Glu) activates at least three types of receptors the NMDA, AMPA, and kainic acid (KAIN) receptors. ...The neurotoxic Amanita muscaria constituent ibotenic acid, a nonselective NMDA receptor ago …
The central excitatory neurotransmitter (S)-glutamic acid (Glu) activates at least three types of receptors the NMDA, AMPA, and kaini …
Ibotenic acid analogues as inhibitors of [3H]glutamic acid binding to cerebellar membranes.
Honoré T, Lauridsen J, Krogsgaard-Larsen P. Honoré T, et al. J Neurochem. 1981 Mar;36(3):1302-4. doi: 10.1111/j.1471-4159.1981.tb01735.x. J Neurochem. 1981. PMID: 7205272
The two preparations (KD = 820 nM, Bmax = 54.5 pmol/mg protein; KD = 509 nM, Bmax = 13.0 pmol/mg protein) showed no difference in specificity of the binding of the ibotenic acid analogues, consistent with the removal of an endogenous inhibitor by the preincubation a …
The two preparations (KD = 820 nM, Bmax = 54.5 pmol/mg protein; KD = 509 nM, Bmax = 13.0 pmol/mg protein) showed no difference in specificit …
Ibotenic acid analogues. Synthesis and biological and in vitro activity of conformationally restricted agonists at central excitatory amino acid receptors.
Krogsgaard-Larsen P, Nielsen EO, Curtis DR. Krogsgaard-Larsen P, et al. J Med Chem. 1984 May;27(5):585-91. doi: 10.1021/jm00371a005. J Med Chem. 1984. PMID: 6325690
A number of analogues of ibotenic acid [(RS)-3-hydroxy-5- isoxazoleglycine ] were synthesized; they were tested as excitants on neurons in the cat spinal cord, by using microelectrophoretic techniques, and as inhibitors of the binding of kainic acid (KA) in v …
A number of analogues of ibotenic acid [(RS)-3-hydroxy-5- isoxazoleglycine ] were synthesized; they were tested as excitants o …
Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.
Hermit MB, Greenwood JR, Nielsen B, Bunch L, Jørgensen CG, Vestergaard HT, Stensbøl TB, Sanchez C, Krogsgaard-Larsen P, Madsen U, Bräuner-Osborne H. Hermit MB, et al. Eur J Pharmacol. 2004 Feb 23;486(3):241-50. doi: 10.1016/j.ejphar.2003.12.033. Eur J Pharmacol. 2004. PMID: 14985045
In this study, we have determined and compared the pharmacological profiles of ibotenic acid and its isothiazole analogue thioibotenic acid at native rat ionotropic glutamate (iGlu) receptors and at recombinant rat metabotropic glutamate (mGlu) receptors expr …
In this study, we have determined and compared the pharmacological profiles of ibotenic acid and its isothiazole analogue thio …
Ibotenic acid lesions of the amygdala basolateral complex or central nucleus differentially effect the response to reductions in reward.
Salinas JA, Parent MB, McGaugh JL. Salinas JA, et al. Brain Res. 1996 Dec 2;742(1-2):283-93. doi: 10.1016/s0006-8993(96)01030-x. Brain Res. 1996. PMID: 9117406
After 8 days of training, half of the rats in each reward condition received vehicle or ibotenic acid administered bilaterally into the amygdala. After 4 days of recovery from the induction of the lesions, training resumed. ...This finding suggests that large amygda …
After 8 days of training, half of the rats in each reward condition received vehicle or ibotenic acid administered bilaterally …
Effect of perinatal alcohol exposure on ibotenic acid-induced excitotoxic cortical lesions in newborn hamsters.
Adde-Michel C, Hennebert O, Laudenbach V, Marret S, Leroux P. Adde-Michel C, et al. Pediatr Res. 2005 Feb;57(2):287-93. doi: 10.1203/01.PDR.0000148712.30716.9D. Epub 2004 Dec 7. Pediatr Res. 2005. PMID: 15585688
The size of lesions induced by 100 ng ibotenic acid was increased in alcohol-exposed pups; the 10 microg dose was lethal. ...This study shows that alcohol exposure at levels that do not induce neuron migration disorders is sufficient to enhance the effects of the hy …
The size of lesions induced by 100 ng ibotenic acid was increased in alcohol-exposed pups; the 10 microg dose was lethal. ...T …
2,759 results