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Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.
Fan L, Zhang X, Huang Y, Zhang B, Li W, Shi Q, Lin Y, Wu F. Fan L, et al. Phytother Res. 2023 Jul;37(7):3025-3041. doi: 10.1002/ptr.7797. Epub 2023 Mar 6. Phytother Res. 2023. PMID: 36879478
Vascular endothelial cell (VEC) injury is a key factor in the development of diabetic vascular complications. Homoplantaginin (Hom), one of the main flavonoids from Salvia plebeia R. ...
Vascular endothelial cell (VEC) injury is a key factor in the development of diabetic vascular complications. Homoplantaginin (Hom), …
Homoplantaginin attenuates high glucose-induced vascular endothelial dysfunction via inhibiting store-operated calcium entry channel and endoplasmic reticulum stress.
Zhou Y, Wang L, Liu Y, Fan L, Zhang X, Shi Q, Li X, Lin Y, Wu F. Zhou Y, et al. J Pharm Pharmacol. 2023 Dec 8;75(12):1530-1543. doi: 10.1093/jpp/rgad087. J Pharm Pharmacol. 2023. PMID: 37774413
This study aims to investigate the protective effect of homoplantaginin (Hom) on HG-induced endothelial dysfunction. METHODS: HG-induced vascular endothelial dysfunction model in human umbilical vein endothelial cells (HUVECs) and rat-isolated thoracic aortas were establis …
This study aims to investigate the protective effect of homoplantaginin (Hom) on HG-induced endothelial dysfunction. METHODS: HG-indu …
Homoplantaginin Inhibits Palmitic Acid-induced Endothelial Cells Inflammation by Suppressing TLR4 and NLRP3 Inflammasome.
He B, Zhang B, Wu F, Wang L, Shi X, Qin W, Lin Y, Ma S, Liang J. He B, et al. J Cardiovasc Pharmacol. 2016 Jan;67(1):93-101. doi: 10.1097/FJC.0000000000000318. J Cardiovasc Pharmacol. 2016. PMID: 26355761
The inhibitory effect of homoplantaginin was further confirmed under lipopolysaccharide challenge. ...Meanwhile, protein and mRNA levels of inflammatory mediators (interleukin-1beta, intercellular cell adhesion molecule-1, and monocyte chemotactic protein-1) were decreased …
The inhibitory effect of homoplantaginin was further confirmed under lipopolysaccharide challenge. ...Meanwhile, protein and mRNA lev …
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.
Meng N, Chen K, Wang Y, Hou J, Chu W, Xie S, Yang F, Sun C. Meng N, et al. Molecules. 2022 Mar 19;27(6):1990. doi: 10.3390/molecules27061990. Molecules. 2022. PMID: 35335352 Free PMC article.
Br., protected vascular endothelial cells by inhibiting inflammation. However, it is undetermined whether homoplantaginin affects atherosclerosis. In this study, we evaluated the effect of homoplantaginin and its derivative dihydrohomoplantagin on oxLDL-induced endo …
Br., protected vascular endothelial cells by inhibiting inflammation. However, it is undetermined whether homoplantaginin affects ath …
Pharmacokinetics of homoplantaginin in rats following intravenous, peritoneal injection and oral administration.
Cong Y, Wu S, Han J, Chen J, Liu H, Sun Q, Wu Y, Fang Y. Cong Y, et al. J Pharm Biomed Anal. 2016 Sep 10;129:405-409. doi: 10.1016/j.jpba.2016.07.034. Epub 2016 Jul 21. J Pharm Biomed Anal. 2016. PMID: 27474945
In addition, homoplantaginin was administered to rats by intravenous, peritoneal injection and oral administration. The concentrations of homoplantaginin and hispidulin, a metabolite of homoplantaginin, were determined by a validated highperformance liquid ch …
In addition, homoplantaginin was administered to rats by intravenous, peritoneal injection and oral administration. The concentration …
Homoplantaginin modulates insulin sensitivity in endothelial cells by inhibiting inflammation.
Wu F, Wang H, Li J, Liang J, Ma S. Wu F, et al. Biol Pharm Bull. 2012;35(7):1171-7. doi: 10.1248/bpb.b110586. Biol Pharm Bull. 2012. PMID: 22791168 Free article.
Recent data have indicated that inflammation plays an important role in the development of insulin resistance. The present study aims at examining the activity of homoplantaginin, a flavonoid from a traditional Chinese medicine Salvia plebeia R. ...To the PA-impaired insul …
Recent data have indicated that inflammation plays an important role in the development of insulin resistance. The present study aims at exa …
Protective effects of Salvia plebeia compound homoplantaginin on hepatocyte injury.
Qu XJ, Xia X, Wang YS, Song MJ, Liu LL, Xie YY, Cheng YN, Liu XJ, Qiu LL, Xiang L, Gao JJ, Zhang XF, Cui SX. Qu XJ, et al. Food Chem Toxicol. 2009 Jul;47(7):1710-5. doi: 10.1016/j.fct.2009.04.032. Epub 2009 May 3. Food Chem Toxicol. 2009. PMID: 19406199
Br is a traditional Chinese herb which has been considered as an inflammatory mediator used for treatment of many infectious diseases including hepatitis. Previously, the compound homoplantaginin was isolated in our group. Hence, we evaluated the protective effects of h …
Br is a traditional Chinese herb which has been considered as an inflammatory mediator used for treatment of many infectious diseases includ …
Evaluation of the anti-inflammatory material basis of Lagotis brachystachya in HepG2 and THP-1 cells.
Zhu JX, Guo MX, Zhou L, Yi LT, Huang HL, Wang HL, Cheng HY. Zhu JX, et al. J Ethnopharmacol. 2024 Jan 10;318(Pt B):117055. doi: 10.1016/j.jep.2023.117055. Epub 2023 Aug 18. J Ethnopharmacol. 2024. PMID: 37597676
RESULTS: The results found that six compounds, including Echinacoside, Quercetin, Homoplantaginin, Tricin-7-O-glucoside, Apigenin and Luteolin-7-O-beta-d-glucopyranoside, were shown to exhibit significant anti-inflammatory effects in both cell models. ...CONCLUSION: These …
RESULTS: The results found that six compounds, including Echinacoside, Quercetin, Homoplantaginin, Tricin-7-O-glucoside, Apigenin and …
Protective effect of Salvia plebeia R. Br ethanol extract on UVB-induced skin photoaging in vitro and in vivo.
Guo Y, Zhang Y, Wang YS, Ma L, Liu H, Gao W. Guo Y, et al. Photodermatol Photoimmunol Photomed. 2023 Sep;39(5):466-477. doi: 10.1111/phpp.12879. Epub 2023 May 11. Photodermatol Photoimmunol Photomed. 2023. PMID: 37165910
This study aimed to investigate the photoprotective effects of SP on UVB-induced photodamage in immortalized human keratinocytes (HaCaTs) and Kunming mice, as well as its main active components such as homoplantaginin (HP). METHODS: CCK-8 was applied to detect the cell via …
This study aimed to investigate the photoprotective effects of SP on UVB-induced photodamage in immortalized human keratinocytes (HaCaTs) an …
34 results