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Neuroprotective actions of 2-amino-N-(1,2-diphenylethyl)-acetamide hydrochloride (FPL 13950) in animal models of hypoxia and global ischemia.
Palmer GC, Cregan EC, Borrelli AR, Harris EW, Stagnitto ML, Colombo P, Kaiser FC, Murray RJ, Griffith RC, Strand JC. Palmer GC, et al. J Pharmacol Exp Ther. 1995 Aug;274(2):991-1000. J Pharmacol Exp Ther. 1995. PMID: 7636764
In ischemic rats treated with FPL 13950 for 7 days, electrophysiological responses of CA1 neurons (orthodromic and antidromic population spikes, in vitro) were also preserved after FPL 13950 treatment. FPL 13950 was administered i.v. at 3 …
In ischemic rats treated with FPL 13950 for 7 days, electrophysiological responses of CA1 neurons (orthodromic and antidromic …
Anticonvulsant efficacy/safety properties of 2-amino-N-(1,2-diphenylethyl)acetamide hydrochloride.
Palmer GC, Stagnitto ML, Garske GE, Napier JJ, Harris EW, Kaiser FC, Griffith RC, Woodhead JH, White HS, Wolf HH, et al. Palmer GC, et al. J Pharmacol Exp Ther. 1995 Jun;273(3):1023-31. J Pharmacol Exp Ther. 1995. PMID: 7791072
2-Amino-N-(1,2-diphenylethyl)-acetamide-hydrochloride (FPL 13950) was profiled preclinically in rodents for efficacy against convulsions, as well as for acute safety/behavioral observations. FPL 13950 exhibited good oral efficacy and duration of action …
2-Amino-N-(1,2-diphenylethyl)-acetamide-hydrochloride (FPL 13950) was profiled preclinically in rodents for efficacy against c …