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The development of an ELISA-assay for semi-quantitative detection of dihydrogriesenin, a sesquiterpene lactone from Geigeria.
Verschoor JA, Bornman L, Vermeulen NM. Verschoor JA, et al. Onderstepoort J Vet Res. 1987 Mar;54(1):1-4. Onderstepoort J Vet Res. 1987. PMID: 3587924
Certain species of Geigeria contain sesquiterpene lactones which cause vomiting disease in sheep. Dihydrogriesenin (DHG), a sesquiterpene lactone from G. asperta, contains an alpha-methylene function which can spontaneously react with thiol groups on proteins to form a cov …
Certain species of Geigeria contain sesquiterpene lactones which cause vomiting disease in sheep. Dihydrogriesenin (DHG), a sesquiter …
The influence of the sesquiterpene lactones from Geigeria on mast cell degranulation.
Gaspar AR, Verschoor JA, Neitz AW, Vermeulen NM. Gaspar AR, et al. Biochem Pharmacol. 1987 Aug 1;36(15):2461-5. doi: 10.1016/0006-2952(87)90517-x. Biochem Pharmacol. 1987. PMID: 2440443
Geigerin(V), which lacks an alpha-methylene group and the chemically prepared cysteine-adduct of dihydrogriesenin(I), were also capable of inhibiting mast cell secretion by Compound 48/80, but to a lesser extent....
Geigerin(V), which lacks an alpha-methylene group and the chemically prepared cysteine-adduct of dihydrogriesenin(I), were also capab …
Effects of sesquiterpene lactones on mitochondrial oxidative phosphorylation.
Narasimham TR, Kim HL, Safe SH. Narasimham TR, et al. Gen Pharmacol. 1989;20(5):681-7. doi: 10.1016/0306-3623(89)90107-9. Gen Pharmacol. 1989. PMID: 2532610
The toxic plant sesquiterpene lactones, helenalin, hymenoxon, mexicanin-E, tenulin, dihydrogriesenin, and psilotropin which were isolated from Helenium, Hymenoxys, and Geigeria spp markedly inhibited "state 3" respiration in mouse hepatic mitochondria. With the exception o …
The toxic plant sesquiterpene lactones, helenalin, hymenoxon, mexicanin-E, tenulin, dihydrogriesenin, and psilotropin which were isol …