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1978 1
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1985 1
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1989 1
1990 1
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1992 1
1993 2
1994 3
1995 2
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1998 8
1999 4
2000 3
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2002 6
2003 2
2004 5
2005 5
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Unravelling the pharmacological properties of cryptolepine and its derivatives: a mini-review insight.
Tudu CK, Bandyopadhyay A, Kumar M, Radha, Das T, Nandy S, Ghorai M, Gopalakrishnan AV, Proćków J, Dey A. Tudu CK, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Feb;396(2):229-238. doi: 10.1007/s00210-022-02302-7. Epub 2022 Oct 17. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 36251044 Free PMC article. Review.
Cryptolepine (1,5-methyl-10H-indolo[3,2-b]quinoline), an indoloquinoline alkaloid, found in the roots of Cryptolepis sanguinolenta (Lindl.) ...This review of the latest research data can be exploited to create a basis for the discovery of new cryptolepine-based drug …
Cryptolepine (1,5-methyl-10H-indolo[3,2-b]quinoline), an indoloquinoline alkaloid, found in the roots of Cryptolepis sanguinolenta (L …
Mineral Fertilization Influences the Growth, Cryptolepine Yield, and Bioefficacy of Cryptolepis sanguinolenta (Lindl.) Schlt.
Amissah JN, Alorvor FE, Okorley BA, Asare CM, Osei-Safo D, Appiah-Opong R, Addae-Mensah I. Amissah JN, et al. Plants (Basel). 2022 Jan 1;11(1):122. doi: 10.3390/plants11010122. Plants (Basel). 2022. PMID: 35009125 Free PMC article.
The results showed the application of N (in the form of Urea or NPK) increased root biomass yield, cryptolepine content, and cryptolepine yield compared to unfertilized plants. The 9-month-old plants recorded the maximum cryptolepine content (2.26 mg/100 mg d …
The results showed the application of N (in the form of Urea or NPK) increased root biomass yield, cryptolepine content, and crypt …
Cryptolepine Suppresses Colorectal Cancer Cell Proliferation, Stemness, and Metastatic Processes by Inhibiting WNT/beta-Catenin Signaling.
Quarshie JT, Fosu K, Offei NA, Sobo AK, Quaye O, Aikins AR. Quarshie JT, et al. Pharmaceuticals (Basel). 2023 Jul 19;16(7):1026. doi: 10.3390/ph16071026. Pharmaceuticals (Basel). 2023. PMID: 37513937 Free PMC article.
RT-qPCR analyses showed that cryptolepine reverses WNT3a-induced expression of beta-catenin, c-MYC, and WISP1, suggesting that cryptolepine inhibits WNT3a-mediated activation of WNT/beta-catenin signaling. Cryptolepine also repressed WNT3a-induced OCT4 and CD …
RT-qPCR analyses showed that cryptolepine reverses WNT3a-induced expression of beta-catenin, c-MYC, and WISP1, suggesting that cry …
Solid-lipid nanoparticle formulation improves antiseizure action of cryptolepine.
Mante PK, Adomako NO, Antwi P, Kusi-Boadum NK, Osafo N. Mante PK, et al. Biomed Pharmacother. 2021 May;137:111354. doi: 10.1016/j.biopha.2021.111354. Epub 2021 Feb 6. Biomed Pharmacother. 2021. PMID: 33561642 Free article.
Cryptolepine was isolated and a solid-lipid formulation was prepared. Antiseizure activity of Solid-Lipid Nanoparticle formulation of cryptolepine (SLN-CRYP) was investigated using Pentylenetetrazole (PTZ)-induced model of seizure-like behaviors in Zebrafish with 2. …
Cryptolepine was isolated and a solid-lipid formulation was prepared. Antiseizure activity of Solid-Lipid Nanoparticle formulation of …
Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos.
Mensah KB, Benneh C, Forkuo AD, Ansah C. Mensah KB, et al. Biochem Res Int. 2019 Jul 8;2019:7076986. doi: 10.1155/2019/7076986. eCollection 2019. Biochem Res Int. 2019. PMID: 31360547 Free PMC article.
Lower cryptolepine concentration (<100 muM) caused mortality, approximately 15-18%, only after the 48 hours postfertilization. ...CONCLUSION: Cryptolepine induces malformations, growth retardation, and mortalities in rapidly dividing zebrafish embryos ex vivo....
Lower cryptolepine concentration (<100 muM) caused mortality, approximately 15-18%, only after the 48 hours postfertilization. ... …
Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysis.
Zheng Z, Xu T, Liu Z, Tian W, Jiang ZH, Zhu GY, Li T, Gao J, Bai LP. Zheng Z, et al. Biomed Pharmacother. 2022 Sep;153:113319. doi: 10.1016/j.biopha.2022.113319. Epub 2022 Jun 23. Biomed Pharmacother. 2022. PMID: 35753261 Free article.
Meanwhile, cryptolepine displayed potent suppressive effect on tumor growth in a dose-dependent manner. In 4T1 tumor xenografts, cryptolepine reduced HIF-1alpha protein expression, and thus decreased the levels of both lactate acid and ATP productions. ...
Meanwhile, cryptolepine displayed potent suppressive effect on tumor growth in a dose-dependent manner. In 4T1 tumor xenografts, c …
Indole: The After Next Scaffold of Antiplasmodial Agents?
Surur AS, Huluka SA, Mitku ML, Asres K. Surur AS, et al. Drug Des Devel Ther. 2020 Nov 11;14:4855-4867. doi: 10.2147/DDDT.S278588. eCollection 2020. Drug Des Devel Ther. 2020. PMID: 33204071 Free PMC article. Review.
Indole-based antiplasmodial compounds are endowed with multiple modes of action, of which inhibition of hemozoin formation is the major mechanism of action reported for compounds such as cryptolepine, flinderoles, and isosungucine. Indole-based compounds exert their potent …
Indole-based antiplasmodial compounds are endowed with multiple modes of action, of which inhibition of hemozoin formation is the major mech …
Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase.
Stell JG, Wheelhouse RT, Wright CW. Stell JG, et al. J Pharm Pharmacol. 2012 Feb;64(2):237-43. doi: 10.1111/j.2042-7158.2011.01408.x. Epub 2011 Nov 18. J Pharm Pharmacol. 2012. PMID: 22221099
OBJECTIVES: To investigate the metabolism of cryptolepine and some cryptolepine analogues by aldehyde oxidase, and to assess the implications of the results on the potential of cryptolepine analogues as antimalarial agents. ...KEY FINDINGS: Cryptolepine …
OBJECTIVES: To investigate the metabolism of cryptolepine and some cryptolepine analogues by aldehyde oxidase, and to assess t …
Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine.
Olajide OA, Bhatia HS, de Oliveira AC, Wright CW, Fiebich BL. Olajide OA, et al. Evid Based Complement Alternat Med. 2013;2013:459723. doi: 10.1155/2013/459723. Epub 2013 May 8. Evid Based Complement Alternat Med. 2013. PMID: 23737832 Free PMC article.
Cryptolepine, an indoloquinoline alkaloid in Cryptolepis sanguinolenta, has anti-inflammatory property. ...Results also show that cryptolepine inhibited LPS-induced p38 and MAPKAPK2 phosphorylation in the microglia. ...
Cryptolepine, an indoloquinoline alkaloid in Cryptolepis sanguinolenta, has anti-inflammatory property. ...Results also show that …
Novel glycosylation zinc(II)-cryptolepine complexes perturb mitophagy pathways and trigger cancer cell apoptosis and autophagy in SK-OV-3/DDP cells.
Zhou Z, Du LQ, Huang XM, Zhu LG, Wei QC, Qin QP, Bian H. Zhou Z, et al. Eur J Med Chem. 2022 Dec 5;243:114743. doi: 10.1016/j.ejmech.2022.114743. Epub 2022 Sep 8. Eur J Med Chem. 2022. PMID: 36116236
With the aim of shedding some light on the mechanism of action of zinc(II) complexes in antiproliferative processes and molecular signaling pathways, three novel glycosylated zinc(II)-cryptolepine complexes, i.e., [Zn(QA1)Cl(2)] (Zn(QA1)), [Zn(QA2)Cl(2)] (Zn(QA2)), and [Zn …
With the aim of shedding some light on the mechanism of action of zinc(II) complexes in antiproliferative processes and molecular signaling …
175 results