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Page 1
Ferroptosis-Inhibitory Difference between Chebulagic Acid and Chebulinic Acid Indicates Beneficial Role of HHDP.
Yang L, Liu Y, Zhang W, Hua Y, Chen B, Wu Q, Chen D, Liu S, Li X. Yang L, et al. Molecules. 2021 Jul 15;26(14):4300. doi: 10.3390/molecules26144300. Molecules. 2021. PMID: 34299576 Free PMC article.
The results suggested that (1) chebulagic acid presented a chair conformation, while chebulinic acid presented a skew-boat conformation; (2) the formation of chebulagic acid requires 762.1729 kcal/mol more molecular energy than chebulinic acid; and (3) …
The results suggested that (1) chebulagic acid presented a chair conformation, while chebulinic acid presented a skew-boat con …
Chebulagic acid, a hydrolyzable tannin, exhibited antiviral activity in vitro and in vivo against human enterovirus 71.
Yang Y, Xiu J, Liu J, Zhang L, Li X, Xu Y, Qin C, Zhang L. Yang Y, et al. Int J Mol Sci. 2013 May 3;14(5):9618-27. doi: 10.3390/ijms14059618. Int J Mol Sci. 2013. PMID: 23644889 Free PMC article.
The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication. Chebulagic acid may represent a …
The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficient …
Structural Revisions in Natural Ellagitannins.
Yamada H, Wakamori S, Hirokane T, Ikeuchi K, Matsumoto S. Yamada H, et al. Molecules. 2018 Jul 30;23(8):1901. doi: 10.3390/molecules23081901. Molecules. 2018. PMID: 30061530 Free PMC article. Review.
This review describes the structural revisions of 32 natural ellagitannins, namely alnusiin; alnusnin A and B; castalagin; castalin; casuarinin; cercidinin A and B; chebulagic acid; chebulinic acid; corilagin; geraniin; isoterchebin; nobotanin B, C, E, G, H, I, J, a …
This review describes the structural revisions of 32 natural ellagitannins, namely alnusiin; alnusnin A and B; castalagin; castalin; casuari …
Anti-hyperglycemic effect of chebulagic acid from the fruits of Terminalia chebula Retz.
Huang YN, Zhao DD, Gao B, Zhong K, Zhu RX, Zhang Y, Xie WJ, Jia LR, Gao H. Huang YN, et al. Int J Mol Sci. 2012;13(5):6320-6333. doi: 10.3390/ijms13056320. Epub 2012 May 22. Int J Mol Sci. 2012. PMID: 22754367 Free PMC article.
On the other hand, chebulagic acid showed a weak inhibition of sucrose-hydrolysis activity. Meanwhile, chebulagic acid did not have an obvious influence on intestinal glucose uptake and was not effective on glucose transporters. ...
On the other hand, chebulagic acid showed a weak inhibition of sucrose-hydrolysis activity. Meanwhile, chebulagic ac
Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells.
Kim HJ, Kim J, Kang KS, Lee KT, Yang HO. Kim HJ, et al. Biomol Ther (Seoul). 2014 Jul;22(4):275-81. doi: 10.4062/biomolther.2014.068. Biomol Ther (Seoul). 2014. PMID: 25143804 Free PMC article.
This study was performed to investigate the autophagy enhancing effect of chebulagic acid on human neuroblastoma SH-SY5Y cell lines. We determined the effect of chebulagic acid on expression levels of autophago-some marker proteins such as, DOR/TP53INP …
This study was performed to investigate the autophagy enhancing effect of chebulagic acid on human neuroblastoma SH-SY5Y cell …
Identification of Chebulinic Acid and Chebulagic Acid as Novel Influenza Viral Neuraminidase Inhibitors.
Li P, Du R, Wang Y, Hou X, Wang L, Zhao X, Zhan P, Liu X, Rong L, Cui Q. Li P, et al. Front Microbiol. 2020 Feb 28;11:182. doi: 10.3389/fmicb.2020.00182. eCollection 2020. Front Microbiol. 2020. PMID: 32256457 Free PMC article.
Although several antiviral drugs are currently available, there is an urgent need to develop novel antiviral therapies with different mechanisms of action due to emergence of drug resistance. In this study, two related compounds, chebulagic acid (CHLA) and chebulini …
Although several antiviral drugs are currently available, there is an urgent need to develop novel antiviral therapies with different mechan …
Chebulagic acid attenuates HFD/streptozotocin induced impaired glucose metabolism and insulin resistance via up regulations of PPAR gamma and GLUT 4 in type 2 diabetic rats.
Vasu G, Sundaram R, Muthu K. Vasu G, et al. Toxicol Mech Methods. 2022 Mar;32(3):159-170. doi: 10.1080/15376516.2021.1976333. Epub 2021 Sep 22. Toxicol Mech Methods. 2022. PMID: 34470562
The aim of the present study was to evaluate the effects of chebulagic acid on enzymes involved in carbohydrate metabolism in high-fat diet/streptozotocin-induced diabetic rats. ...On the other hand, the altered activity of carbohydrate metabolic enzymes, PPAR-gamma …
The aim of the present study was to evaluate the effects of chebulagic acid on enzymes involved in carbohydrate metabolism in …
Natural compounds for pediatric cancer treatment.
Ferrucci V, Boffa I, De Masi G, Zollo M. Ferrucci V, et al. Naunyn Schmiedebergs Arch Pharmacol. 2016 Feb;389(2):131-49. doi: 10.1007/s00210-015-1191-5. Epub 2015 Dec 9. Naunyn Schmiedebergs Arch Pharmacol. 2016. PMID: 26650503 Review.
We also focus on some promising natural compounds that have shown excellent results in vitro and in vivo: Chebulagic acid, Apigenin, Norcantharidin, Saffron/Crocin, Parthenolide, Longikaurin E, Lupeol, Spongistatin 1, and Deoxy-variolin B. ...
We also focus on some promising natural compounds that have shown excellent results in vitro and in vivo: Chebulagic acid, Api …
Anti-angiogenic effect of chebulagic acid involves inhibition of the VEGFR2- and GSK-3beta-dependent signaling pathways.
Athira AP, Abhinand CS, Saja K, Helen A, Reddanna P, Sudhakaran PR. Athira AP, et al. Biochem Cell Biol. 2017 Oct;95(5):563-570. doi: 10.1139/bcb-2016-0132. Epub 2017 May 3. Biochem Cell Biol. 2017. PMID: 28467858
Thus, this study was designed to examine the molecular mechanism for the anti-angiogenic effects of chebulagic acid. Results from our investigations using molecular docking studies and human umbilical vein endothelial cells in culture suggested that chebulagic
Thus, this study was designed to examine the molecular mechanism for the anti-angiogenic effects of chebulagic acid. Results f …
Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus.
Duncan MC, Onguéné PA, Kihara I, Nebangwa DN, Naidu ME, Williams DE, Balgi AD, Andrae-Marobela K, Roberge M, Andersen RJ, Niikura M, Ntie-Kang F, Tietjen I. Duncan MC, et al. Molecules. 2020 Jun 24;25(12):2903. doi: 10.3390/molecules25122903. Molecules. 2020. PMID: 32599753 Free PMC article.
Chebulagic acid selectively restores growth of M2(S31N)-expressing yeast. ...In contrast, chebulagic acid inhibits in vitro influenza A replication regardless of M2 sequence, suggesting that it also acts on other influenza targets. ...
Chebulagic acid selectively restores growth of M2(S31N)-expressing yeast. ...In contrast, chebulagic acid inhibi
120 results