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Page 1
Molecular properties of cetiedil and its interactions with erythrocyte membranes.
Narasimhan C, Fung LW. Narasimhan C, et al. J Pharm Sci. 1986 Jul;75(7):654-9. doi: 10.1002/jps.2600750707. J Pharm Sci. 1986. PMID: 3020225
Cetiedil, an antisickling agent and a vascular smooth muscle relaxant, is an amphiphilic molecule. ...Interaction of cetiedil with Band 3 molecules in the erythrocyte membrane is suggested. ...
Cetiedil, an antisickling agent and a vascular smooth muscle relaxant, is an amphiphilic molecule. ...Interaction of cetiedil …
Effect of cetiedil on cation and water movements in erythrocytes.
Schmidt WF 3rd, Asakura T, Schwartz E. Schmidt WF 3rd, et al. J Clin Invest. 1982 Mar;69(3):589-94. doi: 10.1172/jci110485. J Clin Invest. 1982. PMID: 7061704 Free PMC article.
Cetiedil is a potential antisickling agent whose major effect appears to be at the erythrocyte membrane. ...All water movements can be accounted for by cetiedil-induced net cation movements. When 100 microM ouabain is added along with cetiedil, net Nac gain, …
Cetiedil is a potential antisickling agent whose major effect appears to be at the erythrocyte membrane. ...All water movements can b …
An analysis of the mechanism by which cetiedil inhibits the Gardos phenomenon.
Berkowitz LR, Orringer EP. Berkowitz LR, et al. Am J Hematol. 1984 Oct;17(3):217-23. doi: 10.1002/ajh.2830170302. Am J Hematol. 1984. PMID: 6475933
This process, known as the Gardos phenomenon, is inhibited by cetiedil. The present study examines the mechanism by which cetiedil inhibits the Gardos phenomenon. ...Cetiedil did not prevent calcium accumulation. Cetiedil's ability to inhibit anion mov …
This process, known as the Gardos phenomenon, is inhibited by cetiedil. The present study examines the mechanism by which cetiedil …
An analysis of the mechanism by which cetiedil inhibits sickling.
Abu-Salah KM, Gambo AH. Abu-Salah KM, et al. Life Sci. 2002 Jan 18;70(9):1003-11. doi: 10.1016/s0024-3205(01)01477-1. Life Sci. 2002. PMID: 11860149
The activities were inhibited non-competitively at the cetiedil concentration which caused 50% inhibition of each enzyme. ...Cetiedil was found to stimulate K+ release and to inhibit phosphate uptake. ...
The activities were inhibited non-competitively at the cetiedil concentration which caused 50% inhibition of each enzyme. ...Cetie …
A collaborative, double-blind randomized study of cetiedil citrate in sickle cell crisis.
Benjamin LJ, Berkowitz LR, Orringer E, Mankad VN, Prasad AS, Lewkow LM, Chillar RK, Peterson CM. Benjamin LJ, et al. Blood. 1986 May;67(5):1442-7. Blood. 1986. PMID: 3516257 Free article. Clinical Trial.
We have recently completed a double-blind, placebo-controlled, noncrossover study, the goal of which was to determine whether cetiedil citrate (cetiedil) could affect the course of vaso-occlusive crises in sickle cell disease. ...No serious adverse reactions were ob …
We have recently completed a double-blind, placebo-controlled, noncrossover study, the goal of which was to determine whether cetiedil …
Bepridil and cetiedil reversibly inhibit thyroid hormone stimulation in vitro of human red cell Ca2+-ATPase activity.
Dube MP, Davis FB, Davis PJ, Blas SD. Dube MP, et al. Mol Endocrinol. 1987 Feb;1(2):168-71. doi: 10.1210/mend-1-2-168. Mol Endocrinol. 1987. PMID: 2970587
Progressive addition of purified rat testis calmodulin in vitro (10-150 ng calmodulin/mg membrane protein) restored hormone responsiveness in the presence of bepridil and cetiedil. Binding of labeled thyroid hormone by RBC membranes was unaffected by bepridil and cetied …
Progressive addition of purified rat testis calmodulin in vitro (10-150 ng calmodulin/mg membrane protein) restored hormone responsiveness i …
The synthesis and some pharmacological actions of the enantiomers of the K(+)-channel blocker cetiedil.
Roxburgh CJ, Ganellin CR, Shiner MA, Benton DC, Dunn PM, Ayalew Y, Jenkinson DH. Roxburgh CJ, et al. J Pharm Pharmacol. 1996 Aug;48(8):851-7. doi: 10.1111/j.2042-7158.1996.tb03986.x. J Pharm Pharmacol. 1996. PMID: 8887737
Cetiedil ((+/-)-2-cyclohexyl-2-(3-thienyl)ethanoic acid 2-(hexahydro-1 H-azepin-1-yl) ethyl ester) possesses anti-sickling and analgesic, antispasmodic, local anaesthetic and vasodilator activities. ...The enantiomers also differed in their potency as blockers of the incre …
Cetiedil ((+/-)-2-cyclohexyl-2-(3-thienyl)ethanoic acid 2-(hexahydro-1 H-azepin-1-yl) ethyl ester) possesses anti-sickling and analge …
Inhibition of erythrocyte calcium transport by cetiedil.
Levine SN, Berkowitz LR, Orringer EP. Levine SN, et al. Pharmacology. 1988;36(1):44-51. doi: 10.1159/000138345. Pharmacology. 1988. PMID: 2829242
However, in the absence of calmodulin, no inhibition was observed. Likewise, cetiedil inhibited calmodulin-stimulated, but not basal, activities of phosphodiesterase and Ca-ATPase. These data, along with previous reports, suggest that cetiedil does not act by loweri …
However, in the absence of calmodulin, no inhibition was observed. Likewise, cetiedil inhibited calmodulin-stimulated, but not basal, …
Effect of cetiedil on erythrocyte sickling: new type of antisickling agent that may affect erythrocyte membranes.
Asakura T, Ohnishi ST, Adachi K, Ozguc M, Hashimoto K, Singer M, Russell MO, Schwartz E. Asakura T, et al. Proc Natl Acad Sci U S A. 1980 May;77(5):2955-9. doi: 10.1073/pnas.77.5.2955. Proc Natl Acad Sci U S A. 1980. PMID: 6930678 Free PMC article.
The oxygen equilibrium curves of Hb S were not significantly affected by cetiedil. Erythrocytes treated with high concentrations of cetiedil were swollen and became spheroidal. The antisickling effects of cetiedil might be due to an effect on erythrocyte memb …
The oxygen equilibrium curves of Hb S were not significantly affected by cetiedil. Erythrocytes treated with high concentrations of …
88 results