Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 2
1994 1
1995 1
1997 1
1998 2
2004 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

9 results

Results by year

Filters applied: . Clear all
Page 1
Efficient cancer therapy with a nanobody-based conjugate.
Cortez-Retamozo V, Backmann N, Senter PD, Wernery U, De Baetselier P, Muyldermans S, Revets H. Cortez-Retamozo V, et al. Cancer Res. 2004 Apr 15;64(8):2853-7. doi: 10.1158/0008-5472.can-03-3935. Cancer Res. 2004. PMID: 15087403
In vitro experiments showed that the nanobody-enzyme conjugate effectively activated the release of phenylenediamine mustard from the cephalosporin nitrogen mustard prodrug 7-(4-carboxybutanamido) cephalosporin mustard at the surface of carcinoembryonic antigen-expr …
In vitro experiments showed that the nanobody-enzyme conjugate effectively activated the release of phenylenediamine mustard from the cephal …
Genetic construction, expression, and characterization of a single chain anti-carcinoma antibody fused to beta-lactamase.
Goshorn SC, Svensson HP, Kerr DE, Somerville JE, Senter PD, Fell HP. Goshorn SC, et al. Cancer Res. 1993 May 1;53(9):2123-7. Cancer Res. 1993. PMID: 8481914
Tumor cells coated with the fusion protein were sensitive to a cephalosporin mustard prodrug in a dose-dependent fashion comparable to that of enzyme chemically conjugated to F(ab'). ...
Tumor cells coated with the fusion protein were sensitive to a cephalosporin mustard prodrug in a dose-dependent fashion compa …
Synthesis and characterization of monoclonal antibody-beta-lactamase conjugates.
Svensson HP, Wallace PM, Senter PD. Svensson HP, et al. Bioconjug Chem. 1994 May-Jun;5(3):262-7. doi: 10.1021/bc00027a012. Bioconjug Chem. 1994. PMID: 7918745
Although L6-Fab'2-beta L was capable of activating the antitumor prodrug, 7-(phenylacetamido)cephalosporin mustard, it was impaired in its ability to bind to antigens on the H2981 human lung adenocarcinoma cell line. ...Lower concentrations of dimeric L6-beta L comp …
Although L6-Fab'2-beta L was capable of activating the antitumor prodrug, 7-(phenylacetamido)cephalosporin mustard, it was imp …
Monoclonal antibody-beta-lactamase conjugates for the activation of a cephalosporin mustard prodrug.
Svensson HP, Kadow JF, Vrudhula VM, Wallace PM, Senter PD. Svensson HP, et al. Bioconjug Chem. 1992 Mar-Apr;3(2):176-81. doi: 10.1021/bc00014a013. Bioconjug Chem. 1992. PMID: 1515470
Cephalosporin mustard (CM) was designed as an anticancer prodrug that could be activated in a site-specific manner by monoclonal antibody-beta-lactamase conjugates targeted to antigens present on tumor cell surfaces. ...
Cephalosporin mustard (CM) was designed as an anticancer prodrug that could be activated in a site-specific manner by monoclon …
Antitumor activities of a cephalosporin prodrug in combination with monoclonal antibody-beta-lactamase conjugates.
Vrudhula VM, Svensson HP, Kennedy KA, Senter PD, Wallace PM. Vrudhula VM, et al. Bioconjug Chem. 1993 Sep-Oct;4(5):334-40. doi: 10.1021/bc00023a005. Bioconjug Chem. 1993. PMID: 8274516
7-(Phenylacetamido)cephalosporin mustard (CM) and 7-(4-carboxybutanamido)cephalosporin mustard (CCM) were developed as anticancer prodrugs that could be activated site selectively by monoclonal antibody-beta-lactamase conjugates targeted to antigens pr …
7-(Phenylacetamido)cephalosporin mustard (CM) and 7-(4-carboxybutanamido)cephalosporin mustard (CCM) were develo …
Construction, expression, and activities of L49-sFv-beta-lactamase, a single-chain antibody fusion protein for anticancer prodrug activation.
Siemers NO, Kerr DE, Yarnold S, Stebbins MR, Vrudhula VM, Hellström I, Hellström KE, Senter PD. Siemers NO, et al. Bioconjug Chem. 1997 Jul-Aug;8(4):510-9. doi: 10.1021/bc9700751. Bioconjug Chem. 1997. PMID: 9258449
In vitro experiments demonstrated that L49-sFv-bL bound to 3677 melanoma cells expressing the p97 antigen and effected the activation of 7-(4-carboxybutanamido)cephalosporin mustard (CCM), a cephalosporin nitrogen mustard prodrug. ...
In vitro experiments demonstrated that L49-sFv-bL bound to 3677 melanoma cells expressing the p97 antigen and effected the activation of 7-( …
Regressions and cures of melanoma xenografts following treatment with monoclonal antibody beta-lactamase conjugates in combination with anticancer prodrugs.
Kerr DE, Schreiber GJ, Vrudhula VM, Svensson HP, Hellström I, Hellström KE, Senter PD. Kerr DE, et al. Cancer Res. 1995 Aug 15;55(16):3558-63. Cancer Res. 1995. PMID: 7627964
Cephalosporin doxorubicin (C-Dox) and 7-(4-carboxybutanamido)-cephalosporin mustard (CCM) are prodrugs that are catalytically converted by Enterobacter cloacae beta-lactamase (bL) to the active anticancer agents doxorubicin and phenylenediamine mustard, respectively …
Cephalosporin doxorubicin (C-Dox) and 7-(4-carboxybutanamido)-cephalosporin mustard (CCM) are prodrugs that are catalytically …
Therapeutic effects of monoclonal antibody-beta-lactamase conjugates in combination with a nitrogen mustard anticancer prodrug in models of human renal cell carcinoma.
Svensson HP, Frank IS, Berry KK, Senter PD. Svensson HP, et al. J Med Chem. 1998 Apr 23;41(9):1507-12. doi: 10.1021/jm970779w. J Med Chem. 1998. PMID: 9554883
L49-bL was 10-90-fold more potent in vitro than L6-bL for the activation of 7-(4-carboxybutanamido)cephalosporin mustard (CCM), a cephalosporin prodrug of phenylenediamine mustard (PDM). ...
L49-bL was 10-90-fold more potent in vitro than L6-bL for the activation of 7-(4-carboxybutanamido)cephalosporin mustard (CCM) …
Development and activities of a new melphalan prodrug designed for tumor-selective activation.
Kerr DE, Li Z, Siemers NO, Senter PD, Vrudhula VM. Kerr DE, et al. Bioconjug Chem. 1998 Mar-Apr;9(2):255-9. doi: 10.1021/bc970163l. Bioconjug Chem. 1998. PMID: 9548542
The therapeutic effects were comparable to those obtained in mice treated with the previously described L49-sFv-bL/7-(4-carboxybutanamido)-cephalosporin mustard (CCM) combination. However, C-Mel may be more attractive than CCM for clinical development since the rele …
The therapeutic effects were comparable to those obtained in mice treated with the previously described L49-sFv-bL/7-(4-carboxybutanamido)- …