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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 2
1990 2
1991 2
1992 2
1993 4
1994 2
1995 8
1996 14
1997 19
1998 27
1999 30
2000 37
2001 33
2002 40
2003 36
2004 46
2005 39
2006 40
2007 38
2008 47
2009 44
2010 36
2011 30
2012 58
2013 36
2014 39
2015 34
2016 37
2017 43
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2020 26
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2023 38
2024 10

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981 results

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The following term was not found in PubMed: 122544-18-7
Page 1
CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma.
Wang F, Zhao F, Zhang L, Xiong L, Mao Q, Liu Y, Qiu X, Wang X, Shui L, Chen X, Ren K, Shui P, Zhang Q, Deng Y, Li W, Xie X, Wu D, Li T, Lang J, Liu L, Chen H, Xu J, Bai S, Li Z, Yue Q, Chen N, Zhou B, Yi C, Wei Y, Fu Y, Luo Y, Gou Q, Liu L, Liu Y, Kang J, Wang J, Jing D, Zhang F, Yang X, Li X, Jiang T, Zhang Z, Zhou Y, Yi J. Wang F, et al. Mol Cancer. 2022 Jul 25;21(1):153. doi: 10.1186/s12943-022-01623-8. Mol Cancer. 2022. PMID: 35879762 Free PMC article.
BACKGROUND: Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors. ...RESULTS: As a result, CDC6 expression was upregulated in multiple types of cancer, including glioma. ...
BACKGROUND: Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumor …
LncRNA-CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA-215.
Kong X, Duan Y, Sang Y, Li Y, Zhang H, Liang Y, Liu Y, Zhang N, Yang Q. Kong X, et al. J Cell Physiol. 2019 Jun;234(6):9105-9117. doi: 10.1002/jcp.27587. Epub 2018 Oct 26. J Cell Physiol. 2019. PMID: 30362551
Clinically, lncRNA-CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers. ...Moreover, lncRNA-CDC6 could function as competitive endogenous RNA (ceRNA) via directly sponging of microRNA-215 (miR-215), which f …
Clinically, lncRNA-CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers. . …
A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer.
Mourkioti I, Polyzou A, Veroutis D, Theocharous G, Lagopati N, Gentile E, Stravokefalou V, Thanos DF, Havaki S, Kletsas D, Panaretakis T, Logothetis CJ, Stellas D, Petty R, Blandino G, Papaspyropoulos A, Gorgoulis VG. Mourkioti I, et al. J Exp Clin Cancer Res. 2023 Jul 29;42(1):187. doi: 10.1186/s13046-023-02769-z. J Exp Clin Cancer Res. 2023. PMID: 37507762 Free PMC article.
RESULTS: We demonstrate that enzalutamide treatment induces senescence in androgen-sensitive cells via reduction of the replication licensing factor CDC6. Mechanistically, we show that CDC6 downregulation is mediated through endogenous activation of the GATA2 transc …
RESULTS: We demonstrate that enzalutamide treatment induces senescence in androgen-sensitive cells via reduction of the replication licensin …
The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.
Evrin C, Fernández-Cid A, Riera A, Zech J, Clarke P, Herrera MC, Tognetti S, Lurz R, Speck C. Evrin C, et al. Nucleic Acids Res. 2014 Feb;42(4):2257-69. doi: 10.1093/nar/gkt1148. Epub 2013 Nov 14. Nucleic Acids Res. 2014. PMID: 24234446 Free PMC article.
The replicative mini-chromosome-maintenance 2-7 (MCM2-7) helicase is loaded in Saccharomyces cerevisiae and other eukaryotes as a head-to-head double-hexamer around origin DNA. At first, ORC/Cdc6 recruits with the help of Cdt1 a single MCM2-7 hexamer to form an 'initial' O …
The replicative mini-chromosome-maintenance 2-7 (MCM2-7) helicase is loaded in Saccharomyces cerevisiae and other eukaryotes as a head-to-he …
DNA replication licensing.
Nishitani H, Lygerou Z. Nishitani H, et al. Front Biosci. 2004 Sep 1;9:2115-32. doi: 10.2741/1315. Front Biosci. 2004. PMID: 15353274 Review.
Norcantharidin promotes cancer radiosensitization through Cullin1 neddylation-mediated CDC6 protein degradation.
Deng T, Zhu Q, Xie L, Liu Y, Peng Y, Yin L, Gao Y, Cao T, Fu Y, Qi X, Zhang S, Peng Y, Hou Y, Li X. Deng T, et al. Mol Carcinog. 2022 Aug;61(8):812-824. doi: 10.1002/mc.23435. Epub 2022 Jun 2. Mol Carcinog. 2022. PMID: 35652616
In the present study, we for the first time reported that Norcantharidin (NCTD), a demethylated form of cantharidin, re-sensitized radioresistant cancer cells to overcome radioresistance, and synergistically promoted irradiation (IR)-induced cell killing and apoptosis by inducing …
In the present study, we for the first time reported that Norcantharidin (NCTD), a demethylated form of cantharidin, re-sensitized radioresi …
LINC01088/miR-22/CDC6 Axis Regulates Prostate Cancer Progression by Activating the PI3K/AKT Pathway.
Li J, Huang X, Chen H, Gu C, Ni B, Zhou J. Li J, et al. Mediators Inflamm. 2023 Jul 19;2023:9207148. doi: 10.1155/2023/9207148. eCollection 2023. Mediators Inflamm. 2023. PMID: 37501932 Free PMC article.
Here, we report that the LINC01088/microRNA- (miRNA/miR-) 22/cell division cycle 6 (CDC6) axis regulated through the phosphatidylinositide 3-kinases- (PI3K-) protein kinase B (AKT) signaling pathway controls the development of PCa. ...CDC6 reverses si-linc010 …
Here, we report that the LINC01088/microRNA- (miRNA/miR-) 22/cell division cycle 6 (CDC6) axis regulated through the phosphatidylinos …
Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing.
Zhai Y, Li N, Jiang H, Huang X, Gao N, Tye BK. Zhai Y, et al. Mol Cell. 2017 Jul 20;67(2):168-179. doi: 10.1016/j.molcel.2017.06.016. Mol Cell. 2017. PMID: 28732205 Free article. Review.
Recent cryo-EM structures of the Mcm2-7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2-7 (OCCM) intermediate showed that each of these subunits plays a distinct role in orchestrating the assembly of the pre-replication complex …
Recent cryo-EM structures of the Mcm2-7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2 …
The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer.
Yang C, Xie N, Luo Z, Ruan X, Zhang Y, Wang W, Huang Y. Yang C, et al. Chemotherapy. 2022;67(1):47-56. doi: 10.1159/000519913. Epub 2022 Jan 14. Chemotherapy. 2022. PMID: 35034031
INTRODUCTION: We investigated the function of cell division cycle 6 (CDC6) on the prognosis in colorectal carcinoma (CRC). METHODS: CDC6 protein expression levels in 121 patients with colorectal cancer and adjacent normal mucosa were detected by immunohistoch …
INTRODUCTION: We investigated the function of cell division cycle 6 (CDC6) on the prognosis in colorectal carcinoma (CRC). METHODS: …
Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.
Lim N, Townsend PA. Lim N, et al. Int J Cancer. 2020 Sep 15;147(6):1528-1534. doi: 10.1002/ijc.32900. Epub 2020 Feb 17. Int J Cancer. 2020. PMID: 32010971 Free PMC article. Review.
Indeed, Cdc6 overexpression has been found to be a feature in certain tumours and has been associated as an early event in malignancies. ...In this review, we summarise the evidence for the role of Cdc6 overexpression in cancer, specifically that of pancreatic cance …
Indeed, Cdc6 overexpression has been found to be a feature in certain tumours and has been associated as an early event in malignanci …
981 results