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Page 1
Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide.
Struck RF, Dykes DJ, Corbett TH, Suling WJ, Trader MW. Struck RF, et al. Br J Cancer. 1983 Jan;47(1):15-26. doi: 10.1038/bjc.1983.2. Br J Cancer. 1983. PMID: 6821629 Free PMC article.
Metabolism studies on ifosfamide in mice identified isophosphoramide mustard in blood. In addition, unchanged drug, carboxyifosfamide, 4-ketoifosfamide, dechloroethyl cyclophosphamide, dechloroethylifosfamide, and alcoifosfamide were identified. ...Isophosphoramide mustard …
Metabolism studies on ifosfamide in mice identified isophosphoramide mustard in blood. In addition, unchanged drug, carboxyifosfamide …
Pharmacokinetics, metabolism and clinical effect of ifosfamide in breast cancer patients.
Boddy AV, Proctor M, Simmonds D, Lind MJ, Idle JR. Boddy AV, et al. Eur J Cancer. 1995;31A(1):69-76. doi: 10.1016/0959-8049(94)00300-t. Eur J Cancer. 1995. PMID: 7695982
AUCs of the ultimate alkylating species isophosphoramide mustard (IPM) varied over 6-fold, as did those of the inactivated metabolite carboxyifosfamide (CX). AUCs of dechloroethylated metabolites varied 4-fold (3-dechloroethylifosfamide, 3-DCI) or 8-fold (2-DCI), while tha …
AUCs of the ultimate alkylating species isophosphoramide mustard (IPM) varied over 6-fold, as did those of the inactivated metabolite car …
The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study.
Singer JM, Hartley JM, Brennan C, Nicholson PW, Souhami RL. Singer JM, et al. Br J Cancer. 1998 Mar;77(6):978-84. doi: 10.1038/bjc.1998.161. Br J Cancer. 1998. PMID: 9528844 Free PMC article. Clinical Trial.
A total of 34 patient cycles were studied and serum and urinary levels of IFOS, 2 dechloroethylifosfamide (2DC), 3 dechloroethylifosfamide (3DC), carboxyifosfamide (CX) and isophosphoramide mustard (IPM) were measured by thin-layer chromatography. ...
A total of 34 patient cycles were studied and serum and urinary levels of IFOS, 2 dechloroethylifosfamide (2DC), 3 dechloroethylifosfamide ( …
A new approach to the study of ifosfamide metabolism by the analysis of human body fluids with 31P nuclear magnetic resonance spectroscopy.
Martino R, Crasnier F, Chouini-Lalanne N, Gilard V, Niemeyer U, De Forni M, Malet-Martino MC. Martino R, et al. J Pharmacol Exp Ther. 1992 Mar;260(3):1133-44. J Pharmacol Exp Ther. 1992. PMID: 1545382
In urine, isophosphoramide mustard was detected in addition to the already known human urinary compounds [i.e., unchanged IF, carboxyifosfamide, 2-dechloroethylifosfamide, 3-dechloroethylifosfamide, ketoifosfamide]. 2,3-Didechloroethylifosfamide itself was not found, but t …
In urine, isophosphoramide mustard was detected in addition to the already known human urinary compounds [i.e., unchanged IF, carboxyifos …
Measurement of 4-hydroxylation of ifosfamide in human liver microsomes using the estimation of free and protein-bound acrolein and codetermination of keto- and carboxyifosfamide.
Preiss R, Schmidt R, Baumann F, Hanschmann H, Hauss J, Geissler F, Pahlig H, Ratzewiss B. Preiss R, et al. J Cancer Res Clin Oncol. 2002 Jul;128(7):385-92. doi: 10.1007/s00432-002-0335-4. Epub 2002 Jun 11. J Cancer Res Clin Oncol. 2002. PMID: 12136253
However, after calculating the 4-hydroxylation as the sum of free and protein-bound acrolein and keto- and carboxyifosfamide, a ninefold higher activity (2.40+/-0.73 nmol/min. nmol(P450)) was found. The percentage of the inactive metabolites keto- (25/25) and carboxyifo …
However, after calculating the 4-hydroxylation as the sum of free and protein-bound acrolein and keto- and carboxyifosfamide, a ninef …
Urinary stability of carboxycyclophosphamide and carboxyifosfamide, two major metabolites of the anticancer drugs cyclophosphamide and ifosfamide.
Joqueviel C, Gilard V, Martino R, Malet-Martino M, Niemeyer U. Joqueviel C, et al. Cancer Chemother Pharmacol. 1997;40(5):391-9. doi: 10.1007/s002800050676. Cancer Chemother Pharmacol. 1997. PMID: 9272115
Phosphorus-31 nuclear magnetic resonance spectroscopy was used to evaluate the stability of carboxycyclophosphamide (CXCP) and carboxyifosfamide (CXIF) in human urine at pH 7.0 and 5.5 at 25 degrees, 8 degrees, -20 degrees, and -80 degrees C. ...
Phosphorus-31 nuclear magnetic resonance spectroscopy was used to evaluate the stability of carboxycyclophosphamide (CXCP) and carboxyifo …
Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy.
Boal JH, Ludeman SM, Ho CK, Engel J, Niemeyer U. Boal JH, et al. Arzneimittelforschung. 1994 Jan;44(1):84-93. Arzneimittelforschung. 1994. PMID: 8135883
Identification of CBP was based on chemical shift, chemical stability, and membrane permeability studies of synthetic CBP. Concentrations of carboxyifosfamide (CBIF) formed in K562 cells were also greater than that in U937 cells....
Identification of CBP was based on chemical shift, chemical stability, and membrane permeability studies of synthetic CBP. Concentrations of …
Partitioning of ifosfamide and its metabolites between red blood cells and plasma.
Momerency G, Van Cauwenberghe K, Highley MS, Harper PG, Van Oosterom AT, De Bruijn EA. Momerency G, et al. J Pharm Sci. 1996 Mar;85(3):262-5. doi: 10.1021/js950156a. J Pharm Sci. 1996. PMID: 8699325
The measured compounds were ifosfamide, 2- and 3-dechloroethylifosfamide, 4-ketoifosfamide, carboxyifosfamide, ifosfamide mustard, 2-chloroethylamine and 1,3-oxazolidin-2-one. ...For ifosfamide itself, and metabolites with an intact ring system, a partitioning factor betwe …
The measured compounds were ifosfamide, 2- and 3-dechloroethylifosfamide, 4-ketoifosfamide, carboxyifosfamide, ifosfamide mustard, 2- …
Metabolism of ifosfamide during a 3 day infusion.
Hartley JM, Hansen L, Harland SJ, Nicholson PW, Pasini F, Souhami RL. Hartley JM, et al. Br J Cancer. 1994 May;69(5):931-6. doi: 10.1038/bjc.1994.180. Br J Cancer. 1994. PMID: 8180026 Free PMC article.
Mean values for the proportion of drug excreted as parent compound, 2-dechloroethylifosfamide (2-DC), 3-dechloroethylifosfamide (3-DC), carboxyifosfamide (CX) and ifosforamide mustard (IPM) were 19, 6, 10, 7 and 8% of dose respectively. ...
Mean values for the proportion of drug excreted as parent compound, 2-dechloroethylifosfamide (2-DC), 3-dechloroethylifosfamide (3-DC), c …
18 results