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In vitro activities of acridone alkaloids against Pneumocystis carinii.
Queener SF, Fujioka H, Nishiyama Y, Furukawa H, Bartlett MS, Smith JW. Queener SF, et al. Antimicrob Agents Chemother. 1991 Feb;35(2):377-9. doi: 10.1128/AAC.35.2.377. Antimicrob Agents Chemother. 1991. PMID: 2024971 Free PMC article.
Because a variety of antimalarial agents have also been shown to have activity against Pneumocystis carinii, we tested six of these alkaloids in an established culture model for P. carinii. Atalaphillinine and glycobismine A inhibited growth of cultured P. carinii at conce …
Because a variety of antimalarial agents have also been shown to have activity against Pneumocystis carinii, we tested six of these alkaloid …
In vitro and in vivo activities of atalaphillinine and related acridone alkaloids against rodent malaria.
Fujioka H, Nishiyama Y, Furukawa H, Kumada N. Fujioka H, et al. Antimicrob Agents Chemother. 1989 Jan;33(1):6-9. doi: 10.1128/AAC.33.1.6. Antimicrob Agents Chemother. 1989. PMID: 2653215 Free PMC article.
At a concentration of 10 micrograms/ml in vitro, seven of these alkaloids suppressed 90% or more of Plasmodium yoelii, which causes malaria in rodents. Atalaphillinine, when injected intraperitoneally in a daily dose of 50 mg/kg for 3 days into mice infected with 10(7) ery …
At a concentration of 10 micrograms/ml in vitro, seven of these alkaloids suppressed 90% or more of Plasmodium yoelii, which causes malaria …