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Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1.
Pautus S, Alami M, Adam F, Bernadat G, Lawrence DA, De Carvalho A, Ferry G, Rupin A, Hamze A, Champy P, Bonneau N, Gloanec P, Peglion JL, Brion JD, Bianchini EP, Borgel D. Pautus S, et al. Sci Rep. 2016 Nov 23;6:36462. doi: 10.1038/srep36462. Sci Rep. 2016. PMID: 27876785 Free PMC article.
Annonacinone was identified in a chromogenic screening assay and was more potent than tiplaxtinin. ...SDS-PAGE showed that annonacinone inhibited formation of PAI-1/tPA complex via enhancement of the substrate pathway. ...
Annonacinone was identified in a chromogenic screening assay and was more potent than tiplaxtinin. ...SDS-PAGE showed that annonac …
Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone.
Vila-Nova NS, de Morais SM, Falcão MJ, Alcantara TT, Ferreira PA, Cavalcanti ES, Vieira IG, Campello CC, Wilson M. Vila-Nova NS, et al. Exp Parasitol. 2013 Mar;133(3):334-8. doi: 10.1016/j.exppara.2012.11.025. Epub 2012 Dec 8. Exp Parasitol. 2013. PMID: 23232251 Free PMC article.
A screening assay using luciferase-expressing promastigote form were used to measure the viability of promastigote One coumarin, scoparone, isolated from P. floribundum and two acetogenins, annonacinone and corossolone isolated from A. muricata showed leishmanicidal activi …
A screening assay using luciferase-expressing promastigote form were used to measure the viability of promastigote One coumarin, scoparone, …
Annona cherimola Seed Extracts Trigger an Early Apoptosis Response and Selective Anticlonogenic Activity against the Human Gastric Carcinoma Cell Line SNU-1.
Macuer-Guzmán J, Giovagnoli-Vicuña C, Bernal G, Lobos-González L, de la Fuente-Ortega E, Araya-Castillo M, Ibáñez C. Macuer-Guzmán J, et al. Molecules. 2023 Oct 2;28(19):6906. doi: 10.3390/molecules28196906. Molecules. 2023. PMID: 37836749 Free PMC article.
Moreover, 50 mug/mL of EMCHS extract induced apoptosis, as was shown by the Annexin-V assay. UHPLC-MS/MS analysis detected two acetogenins (Annonacinone and Annonacin) in the EMCHS, which could be largely responsible for its selective antiproliferative effect. ...
Moreover, 50 mug/mL of EMCHS extract induced apoptosis, as was shown by the Annexin-V assay. UHPLC-MS/MS analysis detected two acetogenins ( …
A network pharmacological approach to reveal the multidrug resistance reversal and associated mechanisms of acetogenins against colorectal cancer.
Murugaiyaa Pandiyan S, Shanmugaraj P, Manoharan JP, Vidyalakshmi S. Murugaiyaa Pandiyan S, et al. J Biomol Struct Dyn. 2022;40(24):13527-13546. doi: 10.1080/07391102.2021.1990130. Epub 2021 Oct 20. J Biomol Struct Dyn. 2022. PMID: 34669561
KEGG pathway and Gene Ontology analysis were performed for the predicted CRC targets. We identified four lead AGEs: Muricatocin B, Annonacinone, Annonacin A and Annomuricin E having a higher binding affinity towards MDR proteins. ...
KEGG pathway and Gene Ontology analysis were performed for the predicted CRC targets. We identified four lead AGEs: Muricatocin B, Annona …
New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata.
Liaw CC, Chang FR, Lin CY, Chou CJ, Chiu HF, Wu MJ, Wu YC. Liaw CC, et al. J Nat Prod. 2002 Apr;65(4):470-5. doi: 10.1021/np0105578. J Nat Prod. 2002. PMID: 11975482
Three new monotetrahydrofuran annonaceous acetogenins, muricin H (1), muricin I (2), and cis-annomontacin (3), along with five known acetogenins, annonacin, annonacinone, annomontacin, murisolin, and xylomaticin, were isolated from the seeds of Annona muricata. Additionall …
Three new monotetrahydrofuran annonaceous acetogenins, muricin H (1), muricin I (2), and cis-annomontacin (3), along with five known acetoge …
Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil.
Vila-Nova NS, Morais SM, Falcão MJ, Machado LK, Beviláqua CM, Costa IR, Brasil NV, Andrade Júnior HF. Vila-Nova NS, et al. Rev Soc Bras Med Trop. 2011 Oct;44(5):567-71. doi: 10.1590/s0037-86822011000500007. Rev Soc Bras Med Trop. 2011. PMID: 22031071 Free article.
RESULTS: O-methylarmepavine, a benzylisoquinolinic alkaloid, and a C37 trihydroxy adjacent bistetrahydrofuran acetogenin were isolated from A. squamosa, while two acetogenins, annonacinone and corossolone, were isolated from A. muricata. Against promastigotes, the alkaloid …
RESULTS: O-methylarmepavine, a benzylisoquinolinic alkaloid, and a C37 trihydroxy adjacent bistetrahydrofuran acetogenin were isolated from …
Inhibitory effects on mitochondrial complex I of semisynthetic mono-tetrahydrofuran acetogenin derivatives.
Tormo JR, Gallardo T, Peris E, Bermejo A, Cabedo N, Estornell E, Zafra-Polo MC, Cortes D. Tormo JR, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4101-5. doi: 10.1016/j.bmcl.2003.08.045. Bioorg Med Chem Lett. 2003. PMID: 14592516
Modifications in the terminal alpha,beta-unsaturated gamma-methyl-gamma-lactone moiety or in the alkyl chain that links this terminal gamma-lactone with the alpha,alpha'-dihydroxylated THF system of the natural mono-tetrahydrofuranic acetogenins, annonacin and annonacinone …
Modifications in the terminal alpha,beta-unsaturated gamma-methyl-gamma-lactone moiety or in the alkyl chain that links this terminal gamma- …
[Annomonysvin: a new cytotoxic gamma-lactone-monotetrahydrofuranyl acetogenin from Annona montana].
Jossang A, Dubaele B, Cavé A, Bartoli MH, Bériel H. Jossang A, et al. J Nat Prod. 1991 Jul-Aug;54(4):967-71. doi: 10.1021/np50076a007. J Nat Prod. 1991. PMID: 1791482 French.
The structure of annomontacin [I], a novel monotetrayhydrofuran fatty acid gamma-lactone (acetogenin) isolated from the seeds of Amnona montana, was determined by spectral analysis. The cytotoxicities in vitro of annomontacin [I], annonacinone [2], and annonacin were measu …
The structure of annomontacin [I], a novel monotetrayhydrofuran fatty acid gamma-lactone (acetogenin) isolated from the seeds of Amnona mont …
Method development for quantification of the environmental neurotoxin annonacin in Rat plasma by UPLC-MS/MS and application to a pharmacokinetic study.
Bonneau N, Schmitz-Afonso I, Brunelle A, Touboul D, Champy P. Bonneau N, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 1;1004:46-52. doi: 10.1016/j.jchromb.2015.09.039. Epub 2015 Sep 30. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 26444335
A method for its quantification in Rat plasma was developed, using its analogue annonacinone as an internal standard. Extraction from plasma was performed using ethylacetate with a good recovery. ...
A method for its quantification in Rat plasma was developed, using its analogue annonacinone as an internal standard. Extraction from …